Surviving Sepsis Surviving Sepsis Surviving Sepsis Surviving Sepsis

Campaign Bundles Campaign Bundles Campaign Bundles Campaign Bundles

Initial Resuscitation Bundle Initial Resuscitation Bundle Initial Resuscitation Bundle Initial Resuscitation Bundle
To Be Completed in 3 hours: To Be Completed in 3 hours: To Be Completed in 3 hours: To Be Completed in 3 hours:
1) Measure lactate level 1) Measure lactate level 1) Measure lactate level 1) Measure lactate level
2) Obtain cultures prior to administration of antibiotics 2) Obtain cultures prior to administration of antibiotics 2) Obtain cultures prior to administration of antibiotics 2) Obtain cultures prior to administration of antibiotics
3) Administer broad spectrum antibiotics 3) Administer broad spectrum antibiotics 3) Administer broad spectrum antibiotics 3) Administer broad spectrum antibiotics
4) Administer 30ml/kg crystalloid for hypotension or lactate greater 4) Administer 30ml/kg crystalloid for hypotension or lactate greater 4) Administer 30ml/kg crystalloid for hypotension or lactate greater 4) Administer 30ml/kg crystalloid for hypotension or lactate greater
than or equal to 4mmol/kg than or equal to 4mmol/kg than or equal to 4mmol/kg than or equal to 4mmol/kg

Septic Shock Bundle
To be Completed Within 6 Hours:
1) Apply vasopressors (for hypotension that does not respond to
initial fluid resuscitation) to maintain a mean arterial pressure
(MAP) greater than or equal to 65mmHg
2) In the event of persistent arterial hypotension despite volume
resuscitation (septic shock) or initial lactate greater than or equal
to 4mmol/L
a. Measure central venous pressure (CVP)*
b. Measure central venous oxygen saturation (ScvO2)*
3) Remeasure lactate if initial lactate was elevated*
Septic Shock Bundle
To be Completed Within 6 Hours:
1) Apply vasopressors (for hypotension that does not respond to
initial fluid resuscitation) to maintain a mean arterial pressure
(MAP) greater than or equal to 65mmHg
2) In the event of persistent arterial hypotension despite volume
resuscitation (septic shock) or initial lactate greater than or equal
to 4mmol/L
a. Measure central venous pressure (CVP)*
b. Measure central venous oxygen saturation (ScvO2)*
3) Remeasure lactate if initial lactate was elevated*
Septic Shock Bundle
To be Completed Within 6 Hours:
1) Apply vasopressors (for hypotension that does not respond to
initial fluid resuscitation) to maintain a mean arterial pressure
(MAP) greater than or equal to 65mmHg
2) In the event of persistent arterial hypotension despite volume
resuscitation (septic shock) or initial lactate greater than or equal
to 4mmol/L
a. Measure central venous pressure (CVP)*
b. Measure central venous oxygen saturation (ScvO2)*
3) Remeasure lactate if initial lactate was elevated*
Septic Shock Bundle
To be Completed Within 6 Hours:
1) Apply vasopressors (for hypotension that does not respond to
initial fluid resuscitation) to maintain a mean arterial pressure
(MAP) greater than or equal to 65mmHg
2) In the event of persistent arterial hypotension despite volume
resuscitation (septic shock) or initial lactate greater than or equal
to 4mmol/L
a. Measure central venous pressure (CVP)*
b. Measure central venous oxygen saturation (ScvO2)*
3) Remeasure lactate if initial lactate was elevated*

*Targets for quantitative resuscitation included in the guidelines are CVP *Targets for quantitative resuscitation included in the guidelines are CVP *Targets for quantitative resuscitation included in the guidelines are CVP *Targets for quantitative resuscitation included in the guidelines are CVP
greater than or equal to 8mmHg, ScvO2 greater than or equal to 70% and greater than or equal to 8mmHg, ScvO2 greater than or equal to 70% and greater than or equal to 8mmHg, ScvO2 greater than or equal to 70% and greater than or equal to 8mmHg, ScvO2 greater than or equal to 70% and
normalization of lactate normalization of lactate normalization of lactate normalization of lactate
32011-015 R 4/13 (M) 32011-015 R 4/13 (M) 32011-015 R 4/13 (M) 32011-015 R 4/13 (M)

Surviving Sepsis Surviving Sepsis Surviving Sepsis Surviving Sepsis

Campaign Bundles Campaign Bundles Campaign Bundles Campaign Bundles
Initial Resuscitation Bundle Initial Resuscitation Bundle Initial Resuscitation Bundle Initial Resuscitation Bundle
To Be Completed in 3 hours: To Be Completed in 3 hours: To Be Completed in 3 hours: To Be Completed in 3 hours:
1) Measure lactate level 1) Measure lactate level 1) Measure lactate level 1) Measure lactate level
2) Obtain cultures prior to administration of antibiotics 2) Obtain cultures prior to administration of antibiotics 2) Obtain cultures prior to administration of antibiotics 2) Obtain cultures prior to administration of antibiotics
3) Administer broad spectrum antibiotics 3) Administer broad spectrum antibiotics 3) Administer broad spectrum antibiotics 3) Administer broad spectrum antibiotics
4) Administer 30ml/kg crystalloid for hypotension or lactate greater 4) Administer 30ml/kg crystalloid for hypotension or lactate greater 4) Administer 30ml/kg crystalloid for hypotension or lactate greater 4) Administer 30ml/kg crystalloid for hypotension or lactate greater
than or equal to 4mmol/kg than or equal to 4mmol/kg than or equal to 4mmol/kg than or equal to 4mmol/kg

Septic Shock Bundle
To be Completed Within 6 Hours:
1) Apply vasopressors (for hypotension that does not respond to
initial fluid resuscitation) to maintain a mean arterial pressure
(MAP) greater than or equal to 65mmHg
2) In the event of persistent arterial hypotension despite volume
resuscitation (septic shock) or initial lactate greater than or equal
to 4mmol/L
a. Measure central venous pressure (CVP)*
b. Measure central venous oxygen saturation (ScvO2)*
3) Remeasure lactate if initial lactate was elevated*
Septic Shock Bundle
To be Completed Within 6 Hours:
1) Apply vasopressors (for hypotension that does not respond to
initial fluid resuscitation) to maintain a mean arterial pressure
(MAP) greater than or equal to 65mmHg
2) In the event of persistent arterial hypotension despite volume
resuscitation (septic shock) or initial lactate greater than or equal
to 4mmol/L
a. Measure central venous pressure (CVP)*
b. Measure central venous oxygen saturation (ScvO2)*
3) Remeasure lactate if initial lactate was elevated*
Septic Shock Bundle
To be Completed Within 6 Hours:
1) Apply vasopressors (for hypotension that does not respond to
initial fluid resuscitation) to maintain a mean arterial pressure
(MAP) greater than or equal to 65mmHg
2) In the event of persistent arterial hypotension despite volume
resuscitation (septic shock) or initial lactate greater than or equal
to 4mmol/L
a. Measure central venous pressure (CVP)*
b. Measure central venous oxygen saturation (ScvO2)*
3) Remeasure lactate if initial lactate was elevated*
Septic Shock Bundle
To be Completed Within 6 Hours:
1) Apply vasopressors (for hypotension that does not respond to
initial fluid resuscitation) to maintain a mean arterial pressure
(MAP) greater than or equal to 65mmHg
2) In the event of persistent arterial hypotension despite volume
resuscitation (septic shock) or initial lactate greater than or equal
to 4mmol/L
a. Measure central venous pressure (CVP)*
b. Measure central venous oxygen saturation (ScvO2)*
3) Remeasure lactate if initial lactate was elevated*

*Targets for quantitative resuscitation included in the guidelines are CVP *Targets for quantitative resuscitation included in the guidelines are CVP *Targets for quantitative resuscitation included in the guidelines are CVP *Targets for quantitative resuscitation included in the guidelines are CVP
greater than or equal to 8mmHg, ScvO2 greater than or equal to 70% and greater than or equal to 8mmHg, ScvO2 greater than or equal to 70% and greater than or equal to 8mmHg, ScvO2 greater than or equal to 70% and greater than or equal to 8mmHg, ScvO2 greater than or equal to 70% and
normalization of lactate normalization of lactate normalization of lactate normalization of lactate
32011-015 R 4/13 (M) 32011-015 R 4/13 (M) 32011-015 R 4/13 (M) 32011-015 R 4/13 (M)