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Homeost'sis

– the existence +nd m+inten+nce of + rel+tively const+nt environment within the


body
– the process in which the body undergo physiologic+l processes in order to
m+int+in equilibrium

V'ri'bles
– “conditions”
– v+lues c+n ch+nge
– ex. body temper+ture
○ incre+ses in + hot environment
◆ swe+ting
○ decre+ses in + cold environment
◆ shivering

Set Point (Norm'l R'nge)


– +n ide+l norm+l v+lue +chieved through homeost+tic mech+nisms (see ex.
body temper+ture
Two Types of Physiologic'l Mech'nisms
>. Positive Feedb'ck
– the r+te of + process incre+ses +s the concentr+tion of the product
incre+ses
– enh+nces the effect of the origin+l stimulus
– ex. birth
○ ↑stretching of the uterus (stimulus) = ↑uterine contr+ctions
?. Neg'tive Feedb'ck
– occurs when the r+te of the process decre+ses +s the concentr+tion of
the product incre+ses
– reduces the effect of the origin+l stimulus
– ex. body temper+ture regul+tion
– 3 Components:
○ Receptor
◆ monitors the v+lue of + v+ri+ble
○ Control Center (br'in)
◆ est+blishes the set point
○ Effector
◆ +djusts the v+lues of the v+ri+ble

HOW DO VARIABLES, SET POINTS, AND NORMAL RANGES RELATE TO


HOMEOSTASIS?
– V5ri5bles !re the conditions th!t the body need to cope with. In order to
!chieve homeost5sis, ! set point !cts !s the benchm!rk which the body
must be !ble to !chieve through homeost!tic mech!nisms. However, since
these mech!nisms does not ex!ctly or precisely meet this cert!in set point, !
norm5l r5nge is met.
DISTINGUISH BETWEEN NEGATIVE FEEDBACK AND POSITIVE
FEEDBACK.
– Neg!tive feedb!ck reduces or counter!cts the origin!l stimulus while positive
feedb!ck heightens it.
WHAT ARE THE THREE COMPONENTS OF A NEGATIVE-FEEDBACK
MECHANISM?
– Receptor, control center, !nd effector
GIVE AN EXAMPLE OF HOW A NEGATIVE-FEEDBACK MECHANISM
MAINTAINS HOMEOSTASIS.
– Incre!se in body temper!ture (receptor) c!uses the swe!t gl!nds (effectors)
to produce swe!t in order to cool down the body.
GIVE AN EXAMPLE OF A POSITIVE-FEEDBACK MECHANISM THAT
MAY BE HARMFUL TO THE BODY AND AN EXAMPLE OF ONE THAT IS
NOT HARMFUL.
– H!rmful: Blood loss
○ Less blood circul!ting me!ns reduced blood pressure !nd reduced

perfusion (penetr!tion of blood) to the br!in !nd other vit!l org!ns.
– Not h!rmful: Blood clott
○ When ! vessel is d!m!ged, pl!telets st!rt to cling to the injured site !nd
rele!se chemic!ls th!t !ttr!ct more pl!telets, which will soon form ! clot.

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