he Course No: BME 301, Course Title: Bioclectricty Semester: January, Year-2018 ‘Name: Navid Ubtehey Nveane Student ID; 1518 1. The table below gives the intracellular and extracellular o ‘concentrations for different ions fora mammalian cell: Concentration (mM) | Yon Intracellular Extracellular K 140 5 Nal 10 145 | cf 4 10 | a) Ifthe cell is only permeable to K*, what is the membrane potential? ’) Ifthe cell is only permeable to Na’, what is the membrane potential? ©) If the cell is only permeable to Cl’, what is the membrane potential? 4) Why cannot we estimate the membrarie potential from the Nerast-Planck equation by assuming the membrane permeable to several ions at once? (4x28) ‘The resting values of the conductances for the different ions are given below: Resting Conductance ( mS/em") 0.177 0.116 0.707 ©) Using parallel-conductance equation, estimate the resting transmembrane potential. (2) 1) From your calculations, draw the parallel-conductance model of the membrane at resting conditions. Label clearly the value of all voltages and currents, Assume the ‘transmembrane capacitance to be 1 F/em?, Carry out any other calculations if necessary. (ao) The Nersh -Plomd eq? can be Suebated by BE tog Civle” fa wth & ony permentie P Leple ) Bra > BE to 198) = 54-36 mV 9 be > BS toy (49) 2 sade my a . 3) Pecuye toneanbration & a ane cote : dstomsa) etrcor | Sandton of She magn Cn) aete) 4 ) Vat taka t 4.bne 4 3b Perret etree Omran Cc 4 A wet Oy = 2 FOEA(-8Ame) 4 ouex SEEH OTA OOF 4 ONG tOFOL cr een Enbee WALher Te = 94 (Vm Ex) = oft (- Soot +344) = SVE mA a Ju but we arouse ‘ch fe grephtned re tne ual) Vin Vout 2 Ane 2 oi ( ~Gl-of- 7 at) O poke dre masted ve Fram ‘in te ov = NN 4g mi Show be 2\ther vevowd 2 cept Ta. 3, (¥n-tes) poitive tf Vouk Mia caine = 0-FoF (Unt + 93-48) mode righ = 10, Bl aA at not bath Aero fe corre % Cenomber