PA DRUG DOSES a Frank Shann Intensive Care Unit Royal Children’s Hospital Parkville, Victoria 3052, AustraliaCONTENTS DRUG COSOS yrs: soesascsicenvescoleterccraserecs ea infusion rates table... 59 Cytochrome P450-CYP3A effects .. 105 Alveoiar-arterial O, diff, MAP, Ol, VI... 107 Muscle relaxants .... 107 Pacemaker codes .. . 107 Intravenous catheters . 107 Haematology ............. . 107 Fluid and electrolytes . 108 Dialysis ........ . 108 Ventilation .... - 108 immunisation schedule .. + 109 Antibiotic guidelines .......... 109 Normal values: blood, sweat, urine, CSF...... 111 Haemofiltration, plasmafiltration, ECMO ...... 113 Pharmacokinetic formulae ........... sd Drug infusion compatibility table .. Resuscitation table 0.0... ceoeene ACKNOWLEDGEMENTS In 1983, Alan Duncan suggested that it would be a good idea to publish the list of drug doses that | had compiled for my own use. Alan wrote the resuscitation table and suggested the inclusion of normal values. The antibiotic guidelines were adapted from notes written by Mike South. Stephanie Brumby, Rob Henning, Mike Clifford, Trevor Duke, Johnny-Millar, Jim Tibballs, Warwick Butt, and many others have also helped.DRUGS ARE LISTED BY GENERIC NAME 1/100=1%=10mg/ml, 1/1000=1mg/mi, 1/10000=0.1mg/m! Abacavir (ABC). 8mg/kg (adult 300mg) 12H oral. Abacavir 600mg + lamivudine 300mg. >16yr: 1 tab daily. Abacavir 300mg + lamivudine 150mg + zidovudine 300mg. >40kg: 1 tab 12H oral Abarelix. Adult (NOT/kg): 1 vial (delivers 100mg) IM on days 1, 15 and 29, and then every 28 days. Abatacept. NOT/kg: 500mg (40-60kg) 750mg (60-100 kg) 19 (>100kg) IV over 30min day 1, 2wk, 4wk, then every 4wk. Abciximab. 0.25mg/kg IV stat 10min before angioplasty, then 0.2meg/kg/min (max 10meg/min) IV for 12hr. Abiraterone. Adult (NOT/kg): 1g daily + prednisolone 5mg 12H oral. Monitor hepatic enzymes. Acamprosate. Adulf (NOT/kg). <60kg: 666mg mane, 333mg noon and nocte oral. >60kg: 666mg 8H. Acarbose. 1-4mg/kg (adult 50-200mg) 8H oral, Acebutolol. 4-8mg/kg (adult 200-400mg) 8-24H oral. Aceclofenac. 2mg/kg (adult 100mg) 12H oral. Acemetacin. 1.2mg/kg (adult 60mg) 8-12H oral. Acenocoumarol. See nicoumalone. Acetaminophen. See paracetamol. Acetazolamide. 5-10mg/kg (adult 100-250mg) 6-8H (daily for epilepsy) oral. TB hydrocephalus: 25-50mg/kg 6-8H plus frusemide 0.25mg/kg 6H; may cause severe alkalosis. Acetic acid. 1% 3 drops/ear 8H. Box jellyfish: apply vinegar. Acetohydroxamic acid. S5mg/kg (adult 250mg) 6-8H oral. Acetyl sulfisoxazole. 1.169 = 1.0g sulphafurazole (qv). Acetylcholine chtoride. Adult (NOT/kg): 1% instil 0.5-2ml into anterior chamber of the eye. Acetyicysteine. Liver failure, paracetamol poisoning (regard- less of delay): 150mg/kg in 5%D 1V over thr; then 10mg/kg dhe for 20hr (delay <10hr), 32hr (delay 10-16hr), 72hr (delay >16hr) and longer if still encephalopathic; oral 140mg/kg stat, then 70mg/kg 4H for 72hr. Monitor serum K*. Give if paracetamol >1000umol/L (150mg/L) at 4hr, >500umol/L 8hr, >250umol/L. 12hr. Lung disease: 20% soltn 0.1mi/kg (adult Sml) 6-12H nebulised or intratracheal. Meconium ileus equivalent: 5mi (NOT/kg) of 20% soltn 8H oral; 60-100mi of 50mg/ml for 45 min PR. CF: 4-8mg/kg 8H oral. Acetyicysteine 5% + hypromellose 0.35%. 1 drop/eye 6-8H. Acetyisalicylic acid. See aspirin. Aciclovir. EBV, herpes enceph or sepsis, immunodef, vari- cella IV over Thr: 20mg/kg 12H (<30wk), 8H (30-35wk); 236wk-12yr 500mg/m? 8H; >12yr 10mg/kg 8H. Cutaneous herpes IV over thr: 250mg/m? (birth-12yr) Smag/kg (>12yr) 8H. Genital herpes (>12yr NOT/kg): 200mg oral xS/day for 1