EDIBLE VACCINE Edible vaccines and antibodies are therapeutic proteins.

PRINCIPLE
Take an immunogenic protein and include it in plant

PLANT PROTEIN ROLE

a - transgenic potato plant - surface antigen of Hepatitus B virus - an immune response is generated in the
humans consuming the potato

b - transgenic banana

ADVANTAGES DISADVANTAGES
- attractive in places where certain factors like: - When to administer>
infrastructure - How much? Dosage?
storage - ability to induce immunity on oral consumption
transfer
administration
and the respective costs
Limit the use of traditional vaccines

THERPEUTIC PROTEIN
- plants don't normally produce antibodies in vitro
- but if the encoding genes are introduced, they can, duh

Ex. a specific monoclonal antibody, secretory IgA FUNCTION

Grown in tobacco - bind to the cell surface protein of
S mutans
ADVANTAGE - thus prevent S mutans from binding to tooth enamel
- resistant to proteolysis - thus preventing decay
- higher binding efficiency to anitgens
- most efficiently produced in the plant cells as all transgenes present

IgG, IgG (tobacco, dental carrie and colon cancer)

IgG (soyabean, HSV)