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PHA: Polyhydroxyalkanoates

By Daniela Juarez Picon


Biopolymers are plastics derived from renewable biomass sources
suchas vegetable oil, starch, proteins etc,
Why shall we use PHA?

 First produced around 80’s


 Price related to fossil fuels price

 Now cheaper

 One-use-only products

 Easy to dye
Applications
 Plastics
 Medical implants
 Drug delivery carriers
 Printing and photographic materials
 Nutritional supplements.
Effective microbial production of PHA
depends on several factors:
 The final cell density.
 Bacterial growth rate.
 Percentage of PHA in cell dry weight.
 Time taken to reach high final cell density
 Substrate to product transformation efficiency
 Price of substrates
 Method to extract and purify the PHA
Ralstonia eutropha + E. Coli
Can grow to over 100 g/l containing over 75% PHA after 100 h of fermentation in a one
cubic metre fermentor vessel
Genetic manipulation, fast growth, high final cell density and
ability to utilize inexpensive carbon sources.
Sources:
E. Bugnicourt, P. Cinelli, A. Lazzeri, V. Alvarez. Polyhydroxyalkanoate (PHA): Review of
synthesis,characteristics, processing and potential applications inpackaging.(2014).
Taken from http://www.iris-eng.com/wp-content/uploads/2016/03/EPL-0005219_article.pdf

Guo-Qiang Chen. A microbial polyhydroxyalkanoates (PHA) based bio- and materials industry
(2009). Taken from https://www.ncbi.nlm.nih.gov/pubmed/19623359

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