Professional Documents
Culture Documents
nalise
Perso icine
med nners
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for be 25
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2. stock süd
Concept: Max Brück/Photo: Janine Bächle
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In Switzerland, arms are made, traded, More data, better therapies
Switzerland wants to improve its
carried – and used. We take a closer look at health data and pave the way towards
personalised medicine.
a highly ambivalent relationship.
29
The end of the Aebischer era
12 Patrick Aebischer transformed EPFL into
An unwelcome question one of the world’s best universities.
Armaments money also funds research at Swiss universities. But We take a look back at his time in office.
hardly anyone talks about weapons studies.
15
War in the 21st century
An overview of the technology that will be used in the wars of
the future.
18
Controversial exports
Switzerland trades in war materials, but doesn’t want to encour-
age existing conflicts. It’s complicated.
20
From an armed aristocracy to a peaceful society
The state decides who’s allowed to carry dangerous weapons. But
that wasn’t always the case.
◂ Cover: A paper model of the MP7A1 assault rifle that’s in use all over the ◂ Inside cover: The handicraft kit by Papafoxtrott comprises seven A3 sheets,
world. The real rifle, made by Heckler and Koch, weighs 1.9 kilos and fires up each 0.5 mm thick. Estimated time for completion: 16 hours. Photo: Stöh Grünig
to 950 rounds a minute. Photo: Stöh Grünig
Wikimedia Commons
Keystone/LAIF/Jun Michael Park
32 40 44
Everyday life, then and now Humans are getting competition More than just morphine
Sabine Huebner looks at the lives of the Artificial intelligence is developing swiftly Palliative care doesn’t aim to heal the
little people in ancient times. Patchwork thanks to artificial neural networks. These terminally ill, just ease their suffering.
families were normal back then, too. can learn like real neurones. But it’s facing an uphill task.
34 42 46
Is growth always good? The Mozart of mathematics Swifter-growing grass
In outlying Swiss valleys – like in The complete edition of Leonhard Euler’s A gene could help forage grasses to grow
east German towns – downsizing, not works is nearly finished – but that’s still quicker in future.
investment, might be the solution to not the end.
their problems. 47
43 The useful noise of neurones
37 Cold transistors don’t exist Neurones process electrical signals in
Trepanning wasn’t always deadly Not all forests are alike different ways. This realisation could help
Parliamentarians toe the party line How ice crystals warm the earth us to treat epilepsy.
What birds tell us about equal opportunity
48
Deciphering the bedbug’s genome
How pigs can become organ donors
Singing the brain electric
How large is physical reality? We can only this theory correctly describes the phe- This would mean that the fundamental
see a finite volume out to the horizon – a nomena that we can observe. Likewise, if constants are mere environmental acci-
shell around us, delineating the distance we had a model that described the universe dents – secondary consequences of some
light can have travelled since the big bang. in its earliest moments and that model deeper theory. That naturally disappoints
But that shell has no more physical signif- were based on physics that was corroborat- ambitious theorists, who desire deep ex-
icance than the circle that delineates your ed in other ways, we should take the model planations for the world around us. But our
horizon if you’re in the middle of the ocean. seriously if it predicted multiple big bangs. preferences are irrelevant to the way phys-
We’d expect far more galaxies beyond the ical reality actually is. We should surely be
horizon, and we are surely comfortable open-minded about the possibility of many
that those galaxies exist even though we “Our preferences are universes.
can’t see them. irrelevant to the way
However, even this extended reality Sir Martin Rees is a professor at Cambridge
might not be the end of the story. While physical reality actually is”. University. He is Astronomer Royal and a former
space and time could be limited to the af- Martin Rees president of the Royal Society.
termath of ‘our’ big bang, some theories
suggest that our big bang is in fact one of
many. In other words, what we’ve tradi- Another bone of contention is the idea
tionally called ‘the universe’ may be just (part of string theory) that each universe
one island in a perhaps-infinite archipel- within the multiverse could be governed
ago of space-time. That prompts the ques- by its own set of physical laws. Were this
tion: why should these domains have a the case, there would then be nothing
different epistemological status to the gal- surprising about the fact that we observe
axies beyond our visible horizon? the fundamental constants – the num-
Some claim that unobservable entities bers that determine the kind of universe
aren’t part of science. But I think that’s the we live in – as being tuned to permit the
wrong way to look at things. We can’t look emergence of life. We would of course live
inside black holes, but we believe what rel- in one of the universes where an observer
ativity says about their interiors because could evolve.
The world could be vaster than the region black hole giving rise to a new child uni- I hope it is clear that I respect colleagues
we have mapped out so far. In the past we verse. This mechanism implied a Darwin- who speculate. Maybe the multiverse idea
repeatedly discovered it to be larger than ian evolution that selected the universes will one day give us a serious testable pre-
we had thought. But at each step, it was evi- that generate more black holes – a fasci- diction. But until then physicists should
dence that convinced us. Seventeenth-cen- nating extension of biological concepts to be cautious in selling their speculations as
tury scientist Johannes Kepler showed the cosmos. Indeed, Smolin, unlike many knowledge. It is easy for scientists to get
that a Sun-centred model of the universe proponents of the multiverse, at least tried carried away by their imagination, and the
better predicted planetary motion than hard to deduce observational c onsequences. history of science is full of fascinating ideas
did an Earth-centred one, while at the be- that turned out to be useless. Claiming that
ginning of the twentieth century the as- we know what lies outside the presently
tronomer Henrietta Leavitt developed a “It would be like saying observable universe is like saying that we
new technique that revealed nebulae to be that we have evidence have evidence for angelic choirs outside
distant galaxies. the fixed stars.
The multiverse has no such empirical for angelic choirs”.
basis. In fact, there are numerous, quite Carlo Rovelli Carlo Rovelli is a professor at Aix-Marseille
different, versions of the idea: a zoology of University in France. He co-founded the theory of
multiverse types, each with its own theo- loop quantum gravity.
retical motivation. For example, some cos- A common argument offered to justi-
mologists posit many distinct big bangs, fy the multiverse is that it could ‘explain’
each generating a universe. Some physi- why the constants of nature appear to be
cists, meanwhile, try to make sense of quan- fine-tuned to our existence. But this ar-
tum mechanics’ strangeness by imagining gument is upside down. The fundamental
that our universe continually branches out constants determine the way nature works
into multiple parallel universes. and therefore what exists, not the other
An early version of the idea was put way around. If the constants were differ-
forward in the 1990s by the theoretical ent, the universe would just be different –
physicist Lee Smolin, who suggested that perhaps much richer and more complex,
universes reproduce via black holes: each we don’t yet know enough to say.
Arms research:
defence or offence?
Ever since humans began using tools,
they have been using weapons too. But
trying to talk openly about weapons
is tricky – not least when dealing with
universities.
The dual-use
S
hould a university be allowed
to develop weapons and acquire
joker card
knowledge that might be used for
the purposes of war? This is a com-
plex question, and a political minefield –
as becomes obvious when you try and ask
Swiss universities to respond to it.
Swiss universities don’t like to talk about Many are of the opinion that asking
weapons research. They argue that even about military research is something pure-
ly hypothetical. For example, ETH Zurich
research intended for civil purposes explains its stance as follows: “ETH Zurich
could always be put to military use. does not carry out any weapons research –
projects that are exclusively and explicitly
By Roland Fischer. designed to develop or improve weapons.
That is why there is no register of any such
projects”. The University of Basel clearly
assigns even less significance to the ques-
tion of militarily useful research (in fact, it
assigns it no significance at all): “The Uni-
versity of Basel focuses on the life sciences
and the humanities. In these disciplines we
primarily carry out basic research. Wheth-
er or not the results of this basic research
might be used for military purposes in the
near or distant future is at present impossi-
ble to tell. This is why weapons research is
not a topic here”.
An unwelcome question . . .
EPFL is more explicit. It, too, insists that
it carries out basic research with a pri-
marily civilian focus, and that it always
makes its results public – which, it points
out, is not really compatible with military
research projects. But when asked, it ad-
mits to holding occasional consultations
with the State Secretariat for Economic
Affairs (SECO) regarding export licences
for d
ual-use goods (products that may be
used for both civilian and military purpos-
es) and for ‘special military goods’, in other
words products that may not be employed
directly in battle. EPFL keeps strictly to the
guidelines, it says.
at GSOA, though he believes that a civ- But the Swiss researchers were sur-
il clause would affect only very few pro- prised: they did not find any such close
jects in Switzerland: “Explicit weapons entanglement between the universities
research plays a marginal role at Swiss and the military in Switzerland. Gugerli
universities”. He believes that “even just believes that the reasons for this lie in the
talking about civilian clauses means we’ve founding of ETH Zurich, when a conscious
already made a lot of progress”. decision was made to set itself apart from
The GSOA is trying to get students to the French engineering tradition. The
exert political pressure on university man- Swiss did not want to build palaces and
agement – such as in Bern, for example. fortresses and produce armaments, but in-
The committee of the student body of the stead were concentrating primarily on the
University of Bern is busy acquiring infor- construction industry and mechanical en-
mation from the University’s management gineering. In this sense, Switzerland could
and faculties about the arms research be- well be a special case in weapons research,
ing carried out there. “Our goal is preven- says Gugerli. However, this does not mean
tion. It’s not necessarily about stopping that Swiss industry has simply steered
concrete projects”, says Corina Liebi, a his- clear of arms projects. Gugerli mentions
tory student who initiated the process in Bührle as a case in point, adding that the re-
collaboration with the GSOA. ally interesting question is whether or not
this company actually needed the help of
the federal government in order to achieve
“It would be important its success: “In other European countries,
just to know exactly what is technology polices have a distinctly na-
tional slant, such as is the case in France.
being researched”. In Switzerland, however, when similar pol-
Corina Liebi icies were tried out, they had little success”.
But whoever looks beyond the bounda-
ries of Switzerland to consider the broader
This situates the question about arms history of science has to admit: without
research in a much bigger, political and large-scale projects during and after the
research context, as it touches on the of- Second World War, basic research would
ten-criticised lack of transparency in re- not be where it is today. The Manhattan
search funding from third parties. Liebi is Project, in which some 150,000 researchers
hoping to change this: “It would be impor- and technicians worked on the atom bomb
tant just to know exactly what is being re- from 1942 onwards, set new standards in
searched, and what the deals are”. this regard. As a result, atomic research be-
came a prime example of dual-use technol-
Not much weapons research ogy – and remains so to this day.
However, Swiss universities are not prof-
iting much from armaments funding. The Roland Fischer is a science journalist in Bern.
technology historian David Gugerli was
part of a team tasked with writing the his-
tory of ETH Zurich, and he had expected to
come across a ‘military pedagogical com-
plex’ in the course of their work. Because at
least until the Industrial Revolution, scien-
tists were mostly employed by the military.
They had to be able to construct fortifica-
tions and had to know about ballistics, and
this knowledge was acquired at specialised
educational institutions.
Remote-controlled insects
‘Rods from God’
Nature is superior to our technology into which microcontrollers have
in many ways. So why not bring already been inserted at the larval The 1979 SALT II Treaty forbids the
together biology and technolog- stage, and which then develop into deployment of weapons of mass
ical progress? One of the most remote-controlled, hybrid beings. destruction in orbit. Conventional
surprising research programmes These could be used primarily weapon systems are nevertheless
of the Defense Advanced Research in the areas of surveillance and being developed, including an idea
Projects Agency (DARPA), a branch espionage. The researchers have that the science fiction author Jerry
of the US Defense Department, is also been investigating biologi- Pournelle came up with in the 1950s
called ‘Hybrid Insect Micro-Electro- cal weapons. But very little has and that he called the ‘Thor project’.
Mechanical Systems’. It is trying to emerged as yet about any concrete This involved metal objects being
breed crawling and flying insects research successes. dropped by satellites with pinpoint
accuracy. A few years ago, the US
Air Force presented a system that
featured tungsten rods ten metres
in length that would be able to with-
stand the heat of re-entry into the
Autonomous war machines
atmosphere and would reach speeds
On the battlefields of the future, heel. But they also demonstrate how of over 3,000 metres per second,
machines engage in mighty conflict technology will soon advance far thus allowing them to penetrate
with each other – at least, that’s enough for robots to hunt down en- even the thickest concrete bunkers.
how science fiction sees it. But sci-fi emy soldiers. Algorithms that make But all this is presumably still tomor-
aficionados also know that combat autonomous decisions about life and row’s world: the enormous costs
robots can be used against people. death pose new ethical questions. involved mean that these ‘hyper-
The four-legged robot made by Bos- It’s not just the United Nations that velocity rod bundles’ are likely to
ton Dynamics – bought up by Google follows this question, two thousand remain mere science fiction.
in 2013 – was developed as an au- experts including Stephen Hawking,
tomated packhorse for the military. Steve Wozniak and Noam Chomsky
These machines are decked out spoke out against the use of autono-
with heat sensors and always run to mous weapon systems last year.
Hand guns
Large-calibre firearms
Estonia
Munitions
Military explosives
and fuels
Manned and unmanned
aircraft
Belarus
62.8
Slovakia Ukraine Russia
244.6
Bulgaria Turkey China South Korea
Lebanon
166.7 44.2
Ethiopia Saudi Arabia Oman Singapore Malaysia Indonesia
85.0
Materiel
Dual-use goods
(for civil or military use)
INTERVIEW NEWS
Blog
Being human
What is man? Who are we? Since January gathering together texts in which philos- man. You can find the complete texts from
2016, the philosophical blog ‘Alles rund um ophers discuss these questions and others which the below quotations are taken at
den Menschen’ (‘All about Man’) has been in connection with the state of being hu- blogs.philosophie.ch/mensch.
24 Swiss National Science Foundation – Swiss Academies: Horizons No. 109 For more news, go to www.sciencegeist.com
P E R S O N A L I SE D M E D I C I N E
I
n the future, doctors won’t be con- fewest side-effects. The drug ivacaftor,
cerned about treating just a diseased for example, only works for people with
organ – they’ll be using a mass of data a special variant of the hereditary lung dis-
to get a holistic view of the state of their ease cystic fibrosis. And the duration of the
patients”. This is how the Swiss Centre for Tech- expensive drug courses needed to treat hepati-
nology Assessment describes the dream of per- tis C can be shortened according to the gene vari-
sonalised medicine. In this scenario, drugs will no ants of the people affected.
longer be prescribed only according to a diagnosis,
because gene variants and self-generated data will Unhealthy expectations
be consulted before decisions are made. But let’s clear up a misunderstanding from the
The Scandinavian countries, the EU and the start: medicine has always been personal. The
USA have all set up research initiatives in the present endeavour is just about adapting thera-
field of personalised medicine. And now Switzer- pies to specific characteristics. For this reason,
land wants to do the same. In its ERI Dispatch of people often talk about it as ‘precision medicine’.
February 2016, the Federal Council granted CHF 70 But the path to personalised medicine is a stony
million over four years for a ‘Swiss Personalized one. The biggest hurdles to it include vested inter-
Health Network’. The Swiss Academy of Medical ests, data security and the question of how to im-
Sciences (SAMW) is supposed to coordinate the plement the concept in a practical context. There
many current local initiatives at universities and are sceptics – such as Timothy Caulfield, a Canadian
hospitals and enable the exchange of the extant data. professor of health law and policy, who warns about
“It’s only this large network that will enable us to re- raising false hopes: “There is little reason to suspect
alise the potential of big data in the field of health”, that the promised cost-saving, life-extending, pop-
says Hermann Amstad, General Secretary of SAMW. ulation-health-improving revolution will unfold as
This wealth of information is supposed to enable suggested by [its] many vocal advocates”.
doctors to find the most effective treatment with the
e- PAT I E N T F I L E S
CO H O R T S U R V E YS
BIOBANKS
DATA S ECU R I T Y
S CE P T I CISM A BO U T E V I D E N CE- B A S E D M E D I CI N E
29
Knowledge and politics
I
I think all his efforts were correct. What’s
n 2000, the helm of the Ecole poly- ble in a washing machine. It wasn’t even different is the culture, added to which, our
technique fédérale de Lausanne (EPFL) the easiest way forward for me either, as I Zurich-based twin has relatively fewer re-
was taken up by a complete outsider. was quite happy with my research position. searchers with experience of the US model.
Patrick Aebischer was 44 at the time I’m sure youthful folly also played its part. It’s also a much older institution, making
and a professor at the Vaud University Hos- You came from another institution reform considerably harder.
pital (CHUV). His plan was to introduce life and brought with you a background in Once again, the American model.
sciences to what is a technical university, medicine. Does Switzerland need this Yes, I was strongly influenced by the cul-
to convert it to the American model and to kind of concoction? ture there. It’s a meritocratic system that
make it more competitive. Yes, it’s too scarce. It can bring freedom encourages innovation. There are swathes
This plan quickly ran aground, howev- with it. There comes a time in the life of an of Swiss and European researchers work-
er. While the faculty, the student body and institution when serious reform becomes ing there, many of whom would prefer to
industry were either rejecting his plans necessary and new lifeblood helps. That be closer to their families, but what they
or calling for his departure, Aebischer was said, there are political imperatives for an would also prefer is to return to an envi-
being hampered in his attempts to ap- EPFL president. You have to know the coun- ronment that meets US standards. This is
point vice-presidents. The ETH Board was try. As I stood before the parliament, I was what we have tried to create at EPFL.
against it, and Aebischer had to hold his told, “You’re a Fribourger!” And there I was, In the US, people are very proud to bear
ground firmly, refusing to start work until returning from the US, thinking I was Eu- the name of their university – we wanted to
the Board gave in at the end of a two-week ropean if anything, maybe Swiss, but a Fri- develop the EPFL brand. When taxi drivers
deadlock. bourger! [laughter] in Lausanne claim to be proud of EPFL, it’s
Some 16 years later he has reached his a measure of success.
objectives, and even surpassed them. To- Many industry representatives sit on the
day, EPFL is one of the best European re- “I was strongly influenced by EPFL Strategic Advisory Board.
search institutions and has a portfolio of Besides teaching and research, our mis-
high profile projects, ranging from the the American model” sion also includes the transfer of knowl-
Human Brain Project and Solar Impulse to edge. Our students need to find jobs, and
the Rolex Learning Center. But Aebischer’s we need to understand the profiles sought
style – visionary and proactive – was not Your successor, Martin Vetterli, is by the private sector. Many members of the
free from criticism. Horizons met him this somewhat more traditional. He’s 58 Board are also financial sponsors of major
spring to listen to the defence of his vision years old and has spent 21 years at EPFL. EPFL projects.
for academia and leadership. Is that a problem? To give you an example, the Innova-
No. There’s no reason to change everything tion Park brings together more than 100
You started your presidency with an every time.At any rate, EPFL is going though startups and industry mammoths, such as
uphill struggle. Were you bluffing? a period of consolidation, although I’m not Nestlé, Intel, Peugeot and Logitech.
I wasn’t allowed to select my own manage- a fan of that word. I hold Martin in very Our research excellence has to con-
ment team. It was double or quits. I’d have high regard. Next time around, however, the tribute to the economic development of
returned to the US if it hadn’t worked. I was younger generation should take the reins. French-speaking Switzerland. I’m happy
very clear about my intentions. It’s possible What were your three greatest to note there’s been a significant increase
the Board thought I’d come around once in achievements at EPFL? in the number of our students launching
office . . . but I needed my team to succeed The tenure track for young assistant profes- startups.
with my plans. sors, the doctoral school and the f aculties. Your presidency is associated with
Did this victory provide you with leeway The tenure track means academic inde- private money.
later on? pendence for young researchers. It gives Everybody thought it was impossible to
Yes, obviously. It wasn’t an easy conflict to them the chance to carry out their own re- fundraise in Switzerland, but really no one
live with, however. There were blows com- search projects and to open new paths. It had ever really tried. I spent a great deal
ing from every side, a bit like taking a tum- has completely transformed EPFL. of time creating a network. Having been
Valérie Chételat
A heart for the Ancients
Patchwork families and single-parent
households in Classical Rome: Sabine
Huebner, an assistant professor in Ancient
History in Basel, has been investigating
everyday life in the ancient world.
By Pascale Hofmeier
I
t happened one spring day on the Via ent households were normal”, says Hueb-
Appia. Sabine Huebner was 12 years old ner, who draws a comparison with our own
when she went walking with her par- times: “When we talk about families we of-
ents along the cobblestones of this old ten mean what was considered ideal in the
Roman highway. “The history of the place 1950s – but that state of affairs had never
so gripped me that from this moment on I existed at any other time”.
wanted to study the ancient Romans”. Her Huebner is both an academic and a
childhood enthusiasm led to studies of An- mother of two children – soon to be three –
cient Greek, Latin and ancient history – and and she herself brings up her own family
a smooth career trajectory. After studying situation. She’s always being asked how she
in Münster and Rome she took her doc- manages to combine an academic career
torate in Jena. She also spent five years re- with having a family. This pressure to jus-
searching in the USA, including time spent tify herself sometimes gets on her nerves.
at the University of California, Berkeley “I always just ask in return: ‘Would you ask
and at the Institute for Advanced Study in the same of a man who is a professor and a
Princeton. After taking her postdoctoral father?’”. When Huebner had to move from
habilitation in Ancient History at the Free one country to another because of her aca-
University of Berlin, she was appointed a demic career, her family always went with
Heisenberg Fellow of the German Research her. “The mobility demanded of young aca-
Foundation in Paris and Rome. She’s 39 demics is something I have always seen as
years old now. “I never doubted wanting to a great opportunity, not a burden”. She also
stay in academia”, she says. The University finds the time to go jogging every day and
of Basel is her “dream destination”. it doesn’t stress her out when she has to re-
ply to e-mails at weekends. “I think I’m just
Family and career very efficient”.
Huebner sits, relaxed, in her well-organ- Her doctoral supervisor Walter Ameling
ised office. There’s a computer, a table and can attest to that. These days he’s a pro-
two full bookshelves, one of which is full fessor of Ancient History in Cologne. “Yes,
of historical reference works including that’s the best description for her”, he says.
the great texts of the Ancients. However, She had a doctoral scholarship in Jena that
it’s not Cicero, Homer or the life of the em- lasted for three years. “But unlike many
perors that are the focus of Huebner’s aca- other scholarship holders, she kept to her
demic work. Instead, she’s interested in the schedule”. And another characteristic of
lives of ‘normal’ people. hers became evident during her doctor-
Huebner’s comprehensive list of publi- al studies: independence. “Right from the
cations and editions also makes it evident start she wanted to stay in academia. She
that she’s most passionate about the every- chose her topics herself and sorted out how
day life of ancient times. Many of her works to finance her work”.
are on the social, economic and religious
history of the ‘little people’ and their fami- Everyday matters and fish sauce
ly lives. “A considerable number of children It would be easy to confuse her determina-
in the ancient world grew up without a fa- tion with the somewhat proverbial, ruth-
ther”. Men married later than women and less German trait of efficiency. But this is
often died before their children had grown not how Sabine Huebner comes across, nor
up. “In times of high mortality and divorce is it how others experience her. “She’s not
rates, patchwork families and single-par- the pushy type. Her door is always open
and working with her is a real act of col- The planned edition of the Basel papy-
laboration”, says one of her colleagues on rus collection is also intended to be shown
her current project, which aims to make to the Basel public in an exhibition in ear-
the Basel papyrus collection accessible to ly 2017. Huebner is convinced that “the di-
the public. Papyri are important sources alogue between academia and the public
for the social history of the ancient world. is important – new findings about the an-
“They offer us insights into the lives and cient world can still fascinate a broad spec-
everyday concerns of normal people, and trum of people today”. She regrets that an-
the direct, personal information they offer cient history is slowly disappearing from
makes them an especially fascinating type our schoolrooms: “History doesn’t just be-
of text”, explains Huebner. Simple farmers, gin in the mediaeval period”, says Huebner,
artisans, shepherds, their wives and chil- and offers compelling examples as to why
dren and other socially weak groups speak ancient history is still important in our
to each other and to us through these pa- own times: “Greek philosophy, the Atheni-
pyri – groups of people that we would oth- an concept of democracy, Roman law and
erwise never encounter in the literature of the ancient ideal of beauty are all things
the ancient world. that still have a major impact on European
This collection lay forgotten in Basel for culture to the present day”.
100 years. It had been bought by the Uni-
versity in the late 19th century, when inter- Pascale Hofmeier is a science editor at the SNSF.
national research institutes were compet-
ing for the best items on offer.
Until now, there was only an old-fash-
ioned, incomplete edition of the roughly 65
texts in the collection. The greater number
of them are everyday documents such as
contracts, letters and receipts, written in Single minded
Ancient Greek, Latin, Coptic and Hieratic.
But there is also a copy of Homer’s Iliad Sabine Huebner (39) grew up near Münster
among them. And then there is a private in Germany, the eldest of three daughters
letter from the early third century AD in to parents who were both teachers. She
which a man called Arrian and his brother lives today in a house in Alsace in France
Paul exchange everyday pleasantries, in- together with her husband, the French writer
cluding a discussion of fish sauce.The letter Stéphane Piatzszek, and their two children
is a minor sensation because the two men aged five and two (with a third on the way).
were Christians. “It was only recently that She studied Ancient Greek, Latin and ancient
we were able to prove that this is the oldest history in Münster, Berlin and Rome. In 2005
surviving private correspondence on papy- she completed her doctorate in ancient
rus between Christians, dating back to the history in Jena with a thesis on the organisa-
first half of the third century”. That’s more tion of the church in late antiquity. In 2010
than 50 years earlier than all other extant she completed her postdoctoral habilitation
documents of a comparable nature. Hueb- at the Free University of Berlin with the
ner believes that this can provide us with thesis ‘The Family in Roman Egypt’. Since
new information about the Christianisa- 2014 she has been an assistant professor in
tion of Egypt – and thus also new informa- Basel, where she heads the Department of
tion about processes of societal change. Ancient History.
Safiental’s landscape is dotted with hundreds of little barns. Modern agriculture doesn’t need them, but they’re being kept until a new use is found for them.
No fond farewells
to growth
An ordered retreat could solve the problems
faced by remote mountain regions. But the
political and social resistance to the idea is
great. By Atlant Bieri
A
rule, Swiss parliamentarians don’t have to ornithologically
W
s early as the late Ice Age, medical fear any long-term disciplinary measures
practitioners were opening up the such as exclusion from their party. The hen scientists investigate some-
skulls of their patients – presuma- research group now wants to look closer thing, their own values and
bly in cases of headaches or to treat inju- at the factors that lead politicians to make convictions always play a role.
ries. They mastered various techniques of their decisions. One such example is the work of Mary
the procedure we call trepanning. And the The results of a study carried out by a Elizabeth Barber, who was born in England
survival rate could be high in some places. team from the universities of Basel and in 1818 but emigrated at an early age with
In Great Britain during the Ice Age, some Zurich can perhaps offer information in her parents to the Cape Colony in South
25 percent of patients survived trepanning, this regard. They have been investigating Africa, where she remained for the rest of
but the skulls hitherto investigated in loyalty to the party line, independent of her long life.
Switzerland show an overall survival rate voting procedures. “The biggest group- Barber was the first botanist, ento-
of 78 percent. These statistics are the result ings in the National Council today vote mologist, archaeologist and ornithologist
of research carried out by members of the more as a bloc than was the case twenty of South Africa. When researching birds
Department of Anthropology at the Insti- years ago. In the SVP, unity rose from she specialised in the social behaviour of
tute of Forensic Medicine at the University 80.5 percent in 1995 to over 89 percent both the indigenous and the European
of Bern, led by Sandra Lösch. in 2015”, write S tefanie Bailer and Sarah species that winter in South Africa. “It is
Lösch’s team has been examining the Bütikofer in a study published in 2015. striking that it was through observing
bones from the Celtic burial ground in The reason for this lies in the “increasing birds that Barber found a counter-model
Münsingen that was discovered back in professionalism of the party members and to the predominant Victorian model of the
1906. Two of the 77 well-preserved skulls in the firmer leadership in the party”. In family”, says Tanja Hammel, a historian
have the lesions typical of trepanning. Both this regard, the Swiss parliament is mov- at the University of Basel. She is writing
were adult males and had undergone an ing closer to the norms of other European her doctoral thesis on this important
operation on the site of a previous injury parliaments. Astrid Tomczak-Plekawa scientist, who has been almost completely
on the left side of their cranium that was forgotten until now. Barber highlighted
presumably the result of fi ghting. Ch. Benesch, M. Bütler, K. Hofer: Transparency the fact that female and male birds are
The younger of the two died during the in Parliamentary Voting. CESifo Working Paper equally r esponsible for building nests and
operation, which consisted of scraping No. 5682, 2015 rearing chicks, and hardly display any
back the skin of the parietal bone before S. Bailer und S. Bütikofer: From loose a
lliances gender-specific d ifferences. Hammel ex-
drilling a hole into the skull. The older to professional political players: how Swiss plains: “Her work implicitly laid claim to a
man was operated on twice. “New bone party groups changed, in Swiss Political Science social equality of the sexes, criticising the
tissue has grown on the edges of his bones, Review, 2015 institution of marriage and demonstrating
which means that healing had taken the possibility of alternative relationship
place. So he clearly survived the first tre- models”. With her scientific feminism,
Dominik Feusi
panning”, the researchers explain. In their Mary E lizabeth Barber drew attention to
current study, they have demonstrated a discrimination against women, long be-
survival rate of 33 percent at the excava- fore the women’s rights movement got off
tion site in Münsingen. the ground in South Africa. Urs Hafner
It’s difficult to determine just how
these surgical interventions were carried T. Hammel: Thinking with birds: Mary Elizabeth
out, as there are almost no written sources. Barber’s advocacy for gender equality in
The researchers believe that the patients ornithology, in: Southern African Histories,
were probably first given medicinal plants Kronos, 2015
to make them drowsy, then were given
herbs afterwards that had an antibacterial
effect. Anne-Careen Stoltze Electronic voting makes it possible to find out
exactly how everyone votes.
N. Moghaddam et al.: Survival after trepanation –
Early cranial surgery from late Iron Age Switzerland.
International Journal of Paleopathology (2015)
Into the
high-risk zone
On 1 June 2016, the Gotthard
Base Tunnel opened after just
under 20 years of building
work. Peter Guntli was
involved in the construction
of what is the world’s longest
railway tunnel, working as
chief geologist of the Sedrun
section. He looks back on the
project for us.
“
My daughter was four years old when Over the years I acquired experience in You usually don’t have much time to
she asked my sister: ‘When will Dad- tunnel building. I took courses, but most make elaborate tests in a laboratory. It’s
dy be finished with the tunnel?’ She of it was learning by doing. And so I be- just not possible to stop construction for
answered: ‘When you get your driv- came the head geologist of the S edrun several days at a time. There are objective
ing licence’. So in this sense, we finished section of the Tunnel. criteria that have been catalogued sys-
earlier than we expected back then. My tematically and in detail. But in the end,
daughter is 23 years old today and she still Building a tunnel with gut feeling you’re left with your gut feeling. Or, to put
doesn’t have her driving licence. But the Our main task is to assess the rock in it in more professional language, it’s down
tunnel will open on 1 June this year. For front of us so that we can advise the en- to your experience and good teamwork.
a long time I was unable to contemplate gineers and tunnel constructors as they Luckily, nothing serious happened in my
that this day would actually arrive. But advance: are they going to be confront- section in terms of the geology. But the
now it’s here. After working for 20 years on ed with an unproblematic zone made of ‘normal’ accident risk is still high on such
this project! hard gneiss, where they can make pro- a construction site. If a tool falls 800 me-
I came to the Gotthard Tunnel by gress without undue danger? And will tres down a vertical shaft despite all safe-
chance, really. At the beginning, I had ab- they be able to s ecure the tunnel with ty measures, it’s best not to be standing
solutely no experience. In a normal ge- just five centimetres of sprayed concrete under it. At the beginning in particular, I
ology degree course, you don’t learn how and a few braces? Or is it going to be a had a lot of respect for the tunnel – more
to build shafts or tunnels. We Swiss just high-risk zone with soft, squeezing rock than respect. Even if you get used to the
stood in front of the huge black hole that and a heavy water flow where they will atmosphere over time, it remains some-
was the Sedrun shaft, and we looked down have to carry out advance drilling and in- thing special. It’s not suited to everyone.
and marvelled at what the South African stitute comprehensive sealing and sup- It’s odd to feel that there are thousands of
shaft builders were doing down there. port measures? metres of rock above you, not to mention
”
survey report that they’d struck gold and spent the last two decades on constant Christian Schlüechter, Uni Bern (bottom)
were shutting the tunnel down over East- call, because we’re building round
er in order to go prospecting. One of the the clock. On 1 June I will be very
people higher up who read it actually got happy and very proud, but also very
angry and informed us that the gold be- relieved.
longed to the building contractors, not to
the geologists! As told to Christian Weber.
Always on call
But as a rule, we’re very serious about the
job. We recently had a really strenuous
day at the site, in a zone where there are
many water-carrying layers that we had
to investigate by drilling into them. We
Imitation neurones,
genuine potential
It’s already been 50 years since we first created
algorithms to mimic the working of the human
brain. But only recently have they gained any
traction. Using these artificial neural networks,
artificial intelligence is now making great strides
forward. By Fabien Goubet
I
n March 2016, the world Go champi- translations published on the Internet.
on Lee Sedol lost 1-4 against AlphaGo. By feeding a machine thousands of accu-
For many, this was yet another defeat rately tagged images of cats, for example,
for humanity at the hands of the ma- it learns first to recognise those cats and
chines. Indeed, the success of the AlphaGo later any image of a cat, including those it
software was forged in an area of artificial hasn’t been fed.
intelligence that has seen huge progress
over the last decade. Deep learning, as it’s
called, uses artificial neural networks to Deep learning is still alive
process algorithmic calculations. This soft-
ware architecture therefore mimics biolog- thanks to video games.
ical neural networks.
Much of the progress in deep learning
is thanks to the work of Jürgen Schmid- Deep learning isn’t new; it just needed
huber, director of the IDSIA (Istituto Dalle modern computers to come of age. As far
Molle di Studi sull’Intelligenza Artificiale) back as the early 1950s, biologists tried to
which is located in the suburbs of Luga- lay out formal principles to explain the
no. The IDSIA doctoral student Shane Legg working of the brain’s cells. In 1956, the
and a group of former colleagues went on psychologist Frank Rosenblatt of the New
to found DeepMind, the startup acquired York State Aeronautical Laboratory pub-
by Google in early 2014 for USD 500 mil- lished a numerical model based on these
lion. The DeepMind algorithms eventually concepts, thereby creating the very first
wound up in AlphaGo. artificial neural network. Once integrated
“Schmidhuber is one of the best at deep into a calculator, it learned to recognise ru-
learning”, says Boi Faltings of the EPFL dimentary images.
Artificial Intelligence Lab. “He never let “This network only contained eight
go of the need to keep working at it”. Ac- neurones organised in a single layer. It
cording to Stéphane Marchand-Maillet of could only recognise simple characters”,
the University of Geneva computing de- says Claude Touzet of the Adaptive and
partment, “he’s been in the race since the Integrative Neuroscience Laboratory of
very beginning”. Aix-Marseille University. “It wasn’t until
1985 that we saw the second generation of
Cat photos, thousands of cat photos artificial neural networks featuring multi-
The real strength of deep learning is ple layers and much greater performance”.
structural recognition, and winning at This breakthrough was made simultane-
Go is just an illustration of this, albeit a ously by three researchers: Yann LeCun
rather resounding one. Elsewhere, and in P aris, Geoffrey Hinton in Toronto and
for some years now, we have seen it ap- Terrence S ejnowski in Baltimore.
plied to an entire spectrum of areas, such
as visual and vocal recognition, online Byte-size learning
translation tools and smartphone person- In multilayer networks, each layer learns
al assistants. One underlying principle of to recognise the precise visual character-
machine learning is that algorithms must istics of a shape. The deeper the layer, the
first be trained using copious examples. more abstract the characteristics. With cat
Naturally, this has been helped by the del- photos, the first layer analyses pixel colour,
uge of user-generated content spawned and the following layer recognises the gen-
by smartphones and web 2.0, stretching eral form of the cat. This structural design
from Facebook photo comments to official can support calculations being made upon
thousands of layers, and it was this aspect over by analysing the colours or textures Long Short Term Memory (LSTM) networks
of the architecture that gave rise to the of the fruit in the photo, and so on. In this can distinguish ‘boat’ from ‘float’ by recall-
name ‘deep learning’. way, every step in the process further re- ing the sound that preceded ‘oat’ (i.e., ei-
Marchand-Maillet explains: “Each arti- fines the assessment. ther ‘b’ or ‘fl’). “Recurrent neural networks
ficial neurone is assigned an input value, are more powerful than other approaches
which it computes using a mathematical Video games to the rescue such as the Hidden Markov models”, says
function, only firing if the output exceeds For decades, the frontier of computing held Schmidhuber, who also notes that Google
a pre-defined threshold”. In this way, it back more complex applications, even at Voice integrated LSTMs in 2015. “With
reproduces the behaviour of real neurones, the cutting edge. Industry walked away, looped networks, the number of layers is
which only fire and transmit information and deep learning only survived thanks to potentially infinite”, says Faltings.
when the input signal (the potential differ- the video games sector, which eventually For Schmidhuber, deep learning is just
ence across the entire neural circuit) reach- began producing graphics chips, or GPUs, one aspect of artificial intelligence; the
es a certain level. In the artificial model, with an unprecedented power at accessi- real thing will lead to “the most important
the results of a single layer are weighted, ble prices: up to 6 teraflops (i.e., 6 trillion change in the history of our civilisation”.
added up and then sent as the input signal calculations per second) for a few hundred But Marchand-Maillet sees deep learning
to the following layer, which processes that dollars. “There’s no doubt that it was this as “a bit of hype, leading us to believe that
input using different functions, and so on calculating power that laid the ground for artificial intelligence can learn anything
and so forth. the quantum leap in deep learning”, says provided there’s data. But it’s still an open
Touzet. GPUs are also very good at parallel question as to whether deep learning can
calculations, a useful function for execut- really be applied to every last domain”.
“Real artificial intelligence will ing the innumerable simultaneous opera-
tions required by neural networks. Fabien Goubet is a science journalist for
lead to the most important Although image analysis is getting great Le Temps.
change in the history of our results, things are more complicated for se-
quential data objects such as natural spo-
civilisation”. ken language and video footage. This has
Jürgen Schmidhuber formed part of Schmidhuber’s work since
1989, and his response has been to develop
recurrent neural networks in which neu-
For example, if a system is trained with rones communicate with each other in
great quantities of photos of apples and loops, feeding processed data back into the
watermelons, it will progressively learn to initial layers.
distinguish them on the basis of diameter, Such sequential data analysis is highly
says Marchand-Maillet. If it cannot decide dependent on context and precursory data.
(e.g., when processing a picture of a tiny In Lugano, networks have been instructed
watermelon), the subsequent layers take to memorise the order of a chain of events.
The Mozart of
mathematics
After more than a hundred years,
the publication of the collected
works of Leonhard Euler is
finally nearing completion.
But the archives of this great
mathematician from Basel
still have much more to offer.
By Mathias Plüss
I
t’s simply a huge amount of material”,
says Martin Mattmüller. On the book-
shelf behind him stand the 75 volumes
of the Euler Complete Edition pub-
lished thus far. “It’s barely possible for a
single human being to get to grips with
all of it”. And even more astonishing that a
single man was able to write it all.
Mattmüller is himself also a mathemati-
cian from Basel,and he’s the Secretary of the
Euler Commission. This Commission works
under the auspices of the Swiss Academy
of Natural Sciences (SCNAT) and is respon-
sible for publishing the collected works of
Euler. “Two volumes about astronomy are
still to appear”, he says. He’s 58 now, and
the edition should be finished by the time
he’s 60. “In two years they should be done”.
This means that all of Euler’s publications
will have appeared in a modern edition. The
edition of his letters should also be finished
in the foreseeable future – the last four vol- It took longer to edit Leonhard Euler’s works than it took him to write them
umes are currently being edited. (he lived to the age of 76). Photo: Keystone/Heritage Images/Fine Art Images
Even tiny transistors feel the heat Climate: increased forest growth
colourbox.com
T
at altitude
I
he layperson might not know much
about how computers are actually n his doctoral research, Nicolas
constructed, but many have still Bircher of ETH Zurich has been
heard of Moore’s law, according to which looking at the effects of climate
the number of transistors in an integrated change on Swiss forests. This is a topic of
circuit will double every two years. Phys- concern for both the authorities and the
ical boundaries would seem to mean that forestry industry.
this trend must end. The smallest possible His work involved simulating the
transistors are already under develop- growth of 71 populations of common
ment, and they have a gate length of just Swiss forests for the coming 100 years
five nanometres. Cirrus clouds look like fine brush strokes. But and using a range of scenarios relating
Until now, researchers have assumed they have a major impact on our climate. to climate change and land use (with or
that such small transistors would have without human intervention). Overall,
an advantage, namely that electrons Ice crystal clouds warm the Earth the tests looked at 11 possible changes
C
could flow through them without coming in the climate, including a general rise
into conflict with the atomic lattice of irrus clouds – clouds of ice crystals in t emperatures and reduced summer
the transistors themselves. That would between eight and ten kilometres rainfall. The result is that we should be
save electricity. above the ground – are one of the expecting to see changes in the structure
But the advantages hoped for would greatest uncertainty factors in the models and composition of Swiss forests as of the
seem to be illusory. This has now been that climate researchers use to forecast second half of the twenty-first century.
shown by Reto Rhyner and Mathieu Luisier global warming. For her doctorate at “These models allow us to establish
of ETH Zurich, using atomistic computer ETH Zurich, Erika Kienast (currently of a number of trends, but not to make
simulations of transistors comprising MeteoSwiss) analysed 13,000 hours of any accurate predictions”, says Bircher.
wires three nanometres in length. These measurement data from lidars – instru- “We’ve looked at the basal area, an index
simulations have shown that interactions ments similar to radars, but which use that estimates a forest’s productivity,
with the atomic lattice do indeed take laser beams. She developed an algorithm and noted a reduction for the low-alti-
place: “These interactions inhibit the mo- that allowed her to track cirrus clouds and tude forests on the Swiss Plateau and in
bility of the electrons and the holes – and evaluate their characteristics and their the Jura. At h igher altitudes, however,
this means that the transistors heat up and influence on the Earth’s climate. “Because we noted an increase in the basal area,
energy is lost”, says Luisier. In nanowires of their positive radiative forcing, cirrus particularly in the Alpine foothills, in-
made of silicon, the flow of electricity was clouds act as a kind of blanket, keeping cluding an increase in deciduous trees”.
30 to 50 percent less than expected. the Earth warm”, she explains. Clouds of Another conclusion of the study is that
Rhyner and Luisier also investigated ice crystals let the rays of the sun through, efforts made to plan forests may reduce
how this energy loss might be minimised. but they reflect the Earth’s radiation, and the negative impact of climate change.
Germanium is clearly better suited than this has a warming effect on the climate. “Forest development is strongly tied
silicon, and the organisation of the lattice Lower-lying clouds, on the other hand, to the characteristics of each site, for
also has an impact on the flow. The surface reflect sunlight; this cools down the Earth example, to the soil type. Any strategies
of the nanowires is similarly important, beneath them. must therefore take into account the local
say the two electrical engineers, because This study also found that there are specificities”. Sophie Gaitzsch
the thermic conductibility of the lattice invisible cirrus clouds that had not been
depends to a large degree on its roughness. recognised until now, and which also have N. Bircher: To die or not to die: Forest dynamics in
With these tips, other researchers can now a warming effect on the climate. This Switzerland under climate change. Ph.D. Thesis,
pursue new solutions – and in perhaps effect is only equivalent to five percent ETH Zurich (2015)
five to ten years, highly efficient nano of the impact of the visible cirrus clouds,
wire transistors with ultrashort channel and so is only minor in impact. “Although
Alison Pouliot
lengths will be manufactured. Sven Titz we’ve been researching into clouds for
over 100 years, we still know little about
R. Rhyner and M. Luisier: Minimizing Self-Heating them” says Ulrike Lohmann, a professor of
and Heat Dissipation in Ultrascaled Nanowire experimental atmospheric physics at ETH
Transistors. Nano Letters 16, 2016 Zurich. And indeed, there is no global his-
torical measurement data available. “The
existing data is just a series of snapshots
Wikimedia Commons Dgarte
Medicine’s awkward
relationship with death
Palliative care eases the suffering of
the terminally ill, but many doctors
neglect it. Why? By Susanne Wenger
M
r Lazaroff was in his mid-60s and the University of Bern. In the highly spe-
suffering from metastatic pros- cialised field of medicine, healing is the
tate cancer. He had no hope of a only goal, and death is often regarded as
cure, but was nevertheless sub- mere failure, a defeat.
jected to two operations. Two weeks after
the second, he died in intensive care. “If Countering fantasies of omnipotence
he was pursuing a delusion, so were we”, It’s thanks to the impressive progress
writes the American surgeon Atul Gawan- made by curative medicine that our life ex-
de self-critically in his book ‘Being mortal’. pectancy has almost doubled. But medicine
“We could never bring ourselves to discuss sometimes seems to imagine itself to be
the larger truth about his condition or the omnipotent, says Gian Domenico Borasio, a
ultimate limits of our capabilities, let alone professor of palliative care at the Universi-
what might matter most to him as he ty of Lausanne.
neared the end of his life”. By contrast, palliative medicine a ccepts
that medicine can’t heal every disease.
Relief – the primary concern It asks uncomfortable questions: is
This is where the concept of palliative care everything meaningful just because it’s
comes in. Instead of trying to extend life at possible? “Too much treatment at the close
any cost, its main therapeutic goal is differ- of a life is a huge problem in our health sys-
ent: giving the terminally ill the best possi- tem”, says Borasio. Not just ethically, but
ble life in the time they have left. also financially. It’s not just doctors who
In Switzerland, the federal government are responsible for this, but society as a
and the cantons only set up a national palli- whole. It’s a fact that excessive treatment
ative care strategy in 2015. Terminal care is allows a lot of money to be made. The Swiss
still a young academic discipline here. The health system “is organised on a business
first chair in palliative medicine was only model”, confirms Eychmüller. A dying per-
created in 2011, at the University of Laus- son who refuses expensive medical proce-
anne. Since then, five further chairs have dures soon becomes a negative cost factor.
been created: two in Lausanne and one
each in Geneva, Bern and Zurich – the last Spiritual care is needed
of these being at the Theological Faculty. It was only recently that palliative care
was established as part of a doctor’s gen-
eral training programme. Often it’s equat-
“It’s about a lot more ed with mere pain therapies in the dying
phase. According to Borasio, however, it’s
than just morphine and about “a lot more than just morphine and
holding hands”. holding hands”. The control of physical
symptoms, such as pain and shortness
Gian Domenico Borasio of breath, is only half the story when it
comes to the clinical reality. The other
Palliative care according to the WHO half is just as important: psychosocial and
Things are changing, and yet until now spiritual care.
“Palliative care is an approach that improves supporting the terminally ill seems to have Doctors are afraid of accelerating
the quality of life of patients and their been neglected, even stigmatised in the death by prescribing morphine. But the
families facing the problem associated with medical world. It has been a separate field, life-shortening effect of it “is generally
life-threatening illness, through the preven- only brought into play when a patient is overestimated”, as the Swiss Academy of
tion and relief of suffering by means of early deemed to have exhausted all other pos- Medical Sciences notes in its guidelines on
identification and impeccable assessment sible therapies. “Our field is the enemy of palliative medicine. There are other inter-
and treatment of pain and other problems, curative medicine: dying”, explains Stefan ventions that also require doctors to weigh
physical, psychosocial and spiritual”. Eychmüller, a professor of palliative care at up different factors, adds Eychmüller. “The
seriously ill can also die from an emer- strong images experienced by people close According to its co-author Georg Bosshard,
gency operation or from an experimental to death. Fear is a topic here, but so is trust. a geriatrician at the Zurich University Hos-
chemotherapy that was intended to allevi- Spiritual care is especially important in the pital, we have to expand this comprehen-
ate their suffering”. case of limiting illnesses: “Questions of sive concept to encompass the growing
At the end of a life, collegial teamwork meaning arise. People want to be perceived number of chronically ill people.
is needed that goes beyond the usual hi- as a whole person, also by their doctor”. To be sure, even palliative medicine
erarchies. Doctors work with experts in Peng-Keller has discovered “a gratifying doesn’t have any generally valid criteria
the fields of nursing, psychology, social openness” among his students, both those for a ‘good death’. Dying is as individual as
work and pastoral care. Research, too, has in medicine and those in theology. living, says Gian Domenico Borasio: “The
to cross disciplinary boundaries. Howev- goal is to allow every person to die their
er, because medicine is oriented on prin- Life-extending care own death”. Some decide in favour of as-
ciples from the natural and technological In recent years, two studies from the USA sisted suicide because it is the right way for
sciences, anything that doesn’t fit the usu- and Japan have shown that the terminal- them. “But when people are given expert
al course design runs the risk of being ig- ly ill who are given palliative care live just palliative care, only few of them choose
nored as ‘soft data’. as long as those who are given the usual that way out”.
chemotherapies – and in some cases even
longer. And they enjoy a better quality of Susanne Wenger is a freelance journalist in Bern.
“Dying is the enemy of life, too.
Such findings, says Borasio, help to bring
curative medicine”. palliative care from the margins into the
Steffen Eychmüller centre, and allow medicine as a whole to be
designed in a more patient-centred, com-
municative fashion. This would seem to be
“We still have to develop a common lan- becoming ever more important, given that
guage in palliative research”, says the the- people in Switzerland often refuse life-ex-
ologian Simon Peng-Keller, a professor of tending measures. But not all doctors in-
spiritual care at the University of Zurich. As clude their patients and their environment
part of the National Research Programme in their decisions, as shown recently by a
‘End of life’ (NRP 67), he investigated the study that was conducted as part of NRP 67.
T
he grass might be greener on the Yet surely forage grass would respond to forage grasses. They have found a gene that
other side, but otherwise people the same factors that increase the yield of ensures that the pollen of so-called self-in-
don’t pay much attention to how it grain crops. The main role is played by so- compatible grasses does not form any pol-
grows. And yet some two thirds of called hybrid cultivation, though we are len tubes when it lands on the stigma of a
Switzerland’s agricultural land comprises still only beginning to understand why hy- female flower of the same plant. This gene,
meadows and pastures. So at least in eco- brid plants grow better and stronger than called the S-locus gene, is an important
nomic terms, grass growth is a factor that non-hybrids. Scientists speak of the ‘het- component of a biological mechanism that
we have to bear in mind, and that should be erosis effect’. hinders self-fertilisation, thereby prevent-
optimised where possible. ing inbreeding.
Just under a fifth of our grasslands is Genes discovered against
made up of so-called artificial pasture. Un- inbreeding grasses
like permanent pasture, this is integrated Bruno Studer is an SNSF Professor at the In- “Carefully steering natural
into arable crop rotation and is regularly stitute of Agricultural Sciences at ETH Zu- processes could offer a
seeded with forage grass. The seeds of the rich. He too can only speculate as to what
most important varieties of grass are sub- causes this effect. Hybrids are descended significant increase in yield”.
ject to constant development through cul- from genetically different parents. This is Bruno Studer
tivation. But whereas our success in cul- why they display a maximum degree of
tivating varieties of grain such as wheat, different gene variants. “This gives them
maize or rice has led to spectacular in- much plasticity, meaning they can adapt For his work on self-incompatibility,
creases in yield and entered into the public optimally to many different environmen- Studer was awarded the Wricke Prize at
consciousness as the ‘green revolution’, lit- tal conditions”, he suggests. this year’s conference of the German Soci-
tle attention has been paid to the progress Studer and his team have recently tak- ety for Plant Breeding. The discovery of the
made in cultivating forage grasses. en a big step towards cultivating hybrid S-locus in English rye-grass (Lolium perenne)
marks a milestone in the cultivation of for-
age grasses. “Only with this knowledge can
we take cultivation concepts that were im-
agined decades ago, and implement them
in the real world”, says Studer.
In his mind, one possibility is to use
genetic markers to inform the growers
of which plants can be crossed with each
other. “If we can steer pollination with-
in breeding populations, then we can use
the heterosis effect to increase the yield of
forage grasses significantly – but by natu-
ral means, and without losing any genetic
diversity”.
Beat Reidy, a fodder crop expert at the
School of Agricultural, Forest and Food
Sciences in Zollikofen, also sees great po-
tential in this new finding. However, he
believes that only the coming decades will
show whether the hoped-for progress has
been realised.
Joy for all four stomachs: cows can look forward to succulent progress in the cultivation of forage
grasses. Photo: Keystone/Urs Flüeler
N
ystagmus is a genetically transmit-
ted disease that causes an uncon-
trolled, back-and-forth twitching
of the eyeball. Roughly one in every
1,500 men suffer from it. But before now, we
did not know that this twitching is caused
by retinal neurones making miscalcula-
tions when converting visual stimuli into
electrical signals.
How does the brain – to which the ret-
ina also belongs – understand what infor-
mation is contained in a stimulus? Until
now, it was known that neurones answer
stimuli by firing off salvos of electrical sig-
nals that are transmitted via synapses to
other nerve cells. The information about
the stimulus is actually contained in the
number of impulses and in the time in- In human retinas, the light stimuli are received by photoreceptors (green, top) and processed first by
tervals between them. But just how these nerve cells (bottom, brightly coloured). Photo: Keystone/NIH
codes are read and written is still a subject
of debate among neuroscientists.
sions about the original stimulus. Franke Franke was involved in a study pub-
Useful noise explains this so-called ‘signal noise’ by us- lished in early 2016 that for the first-ever
Felix Franke from the Bioengineering Lab- ing a dice metaphor: “If the stimulus is the time found a connection between nystag-
oratory of ETH Zurich has come one step number three, then one neurone will per- mus in a human eye and a malformation
closer to understanding this process – at haps give us a two, and the neurone next of the retina in mice. It was the first time,
least as far as the retina is concerned. In a to it a four. If we take the average of them says Franke, that a neural calculation was
recently published study in the specialist both, the answer is correct. Viewed individ- recognised as a factor in a human disease.
journal Neuron, Franke’s team investigates ually, each answer would be incorrect”. The At Brown University, Gerhard also sees
whether it is more useful for the brain to ‘orchestra’ is thus more precise than indi- the possibility of therapeutic applications –
‘hear’ a whole orchestra of neurones at the vidual neurones. such as prostheses controlled by thoughts.
same time, or only individual nerve cells. This has been confirmed by the neuro- Arm prostheses could possibly even ‘write’
They found that if the brain hears them all, scientist Felipe Gerhard, who completed in the neural network of the brain and
then it can learn more about the stimulus his doctorate at EPFL and is currently in- thereby recreate a sense of touch.
that caused the impulses – such as a pic- volved in research at Brown University in Currently, Gerhard is working with ep-
ture that the eye has just seen. Providence, USA. The experiments with the ilepsy patients measuring and analysing
rabbit retinas help him to process patterns their neural activity during epileptic fits.
in this signal noise, enabling him to recog- Here, too, patterns in the signal noise play
“We could predict epileptic nise visual stimuli better. These findings a role: “This could allow us to predict ep-
fits and suppress the should be a solid basis for future research ileptic fits. As soon as the fit begins, we
on the neural code. could attempt to stimulate these neu-
abnormal pattern”. But this random signal noise in the brain rones actively, and thereby suppress the
Felipe Gerhard can sometimes also hinder communication abnormal pattern”.
between neurones, says Gerhard: “Evolu-
tion has found ways of dealing with this Martin Angler is a freelance journalist in Bolzano.
In their experiment, Franke’s team noise, and even of using it”. It’s especially
linked the retinas of rabbits, laid out flat, useful for creative thinking, he maintains. F. Franke et al.: Structures of Neural Correlation
with a computer chip containing 11,000 and How They Favor Coding. Neuron (2016)
densely packed electrodes. They then Prostheses with a tactile sense
moved a bright bar past the retinas. The Franke believes that these findings might
neuroscientists were able to record the sig- in future be employed for therapeutic pur-
nals in the photoreceptors as data, via the poses. “If we can understand how neural
electrodes. networks function, then we can also bet-
The problem is that the nerve cells often ter understand the diseases that are con-
answer differently to the same stimulus, nected with them”. Such as the nystagmus
which makes it difficult to form conclu- mentioned above.
Wikipedia Commons/Hellerhoff
P igs could solve the current lack of
donor organs, but the human im-
mune system rejects foreign organs.
Now, however, a research group from the
Geneva University Hospital (HUG) might
have come one step closer to achieving so-
called xenotransplantation.
We know from transplant attempts
with apes that organs from genetical-
ly modified pigs can to some extent
Uncomfortable bedfellows: these blood suckers avoid being regarded as a foreign body Electrodes stimulate deep-lying regions of the
are increasingly resistant to insecticides. by the recipient’s immune system. It is brain, thereby easing symptoms.
also known that human immune cells
Decoding the bedbug (T regulatory cells or ‘treg cells’), which Battling depression with
W
protect the body from its own immune brain pacemakers
F
e’ve never been able to prove system, can suppress the defence reac-
that bedbugs transmit disease tion against transplants. Researchers led or years so-called deep brain stimu-
to humans, despite knowing by Jörg Seebach have succeeded in using lation has been used successfully to
that their bites can cause skin reactions signalling substances from porcine tissue treat diseases such as Parkinson’s.
and phobias. Over the last 20 years, these to attract treg cells in cell cultures. It involves implanting two electrodes in
blood-sucking beasts have made a come- The problem, however, is that other hu- the brain that fire off 150 three-millivolt
back in mattresses across the world and man immune cells could also be attracted electrical impulses every second. This
have become resistant to traditional insec- by these signalling substances from the treatment allows patients to cut up to
ticides. An international team of research- porcine tissue. “But it could be possible 70 percent of their drugs, and can largely
ers has finally sequenced the bedbug’s to reproduce treg calls in the laboratory compensate for the negative consequenc-
genes and identified the components that and to give them to organ recipients”, says es of the disease. Now researchers at the
may explain this adaptation. Seebach. “Another possibility that we’re Universities of Lausanne and Berlin have
“By comparing bedbug DNA against an looking at is to produce transgenic human tested the procedure for the first-ever
enormous library of genes from other in- signalling substances in the pig’s organs time on five patients suffering from severe
sects, we have identified its unique genes, that would attract treg cells”. Seebach depression. One of the patients thereafter
including some that may be involved in hopes this could help to suppress the underwent a major improvement.
the resistance to insecticides”, says Robert immune reaction. In any case, the proce- Together with a team of neurosurgeons,
Waterhouse, a geneticist at the Swiss dure would first have to be subjected to the neurologist Bogdan Draganski from
Institute of Bioinformatics in Geneva. For animal testing. the University Hospital of Lausanne
example, the researchers have described Dan Salomon, an immunologist at the implanted the electrodes in a part of the
genes that neutralise the toxicity of in- Scripps Research Institute in La Jolla, brain called the subgenual grey matter.
secticides and others that have thickened raises doubts, however: “In my opinion, It is found in the frontal lobes and is
the cuticle of the bedbug (their external it’s highly unlikely that tolerance for known to be connected to depression. The
shell) compared to that of their ancestors xenotransplantation could be increased by neurosurgeon carrying out the procedure
of 60 years ago. activating and administering treg cells in made an error with one patient, h owever.
The researchers also discovered the this manner”. Stéphane Hess He placed her electrodes slightly too deep,
genes of bacteria, the origin of which meaning that they reached the gyrus
remains unclear. “If we find them among D. Ehirchiou et al.: Chemoattractant Signals and rectus – an area about which we still
the natural flora of all bedbugs and can Adhesion Molecules Promoting Human R egulatory know little.
establish their role in the bedbug’s sur- T Cell Recruitment to Porcine Endothelium. It was this patient who experienced a
vival, then we can treat infected locations Transplantation (2016) dramatic improvement in her condition.
with specific antibiotics”, says Water- “After the intervention, she had a feeling
house. He hopes the functional analysis of of lightness of being”, says Draganski.
Wikimedia Commons
all these genes will allow him to under- The operation had been a last, desperate
stand the biology of bedbugs and improve measure after many failed therapies. The
the options to fight them. “Until we know result shows that the gyrus rectus could
more about the precise molecular effects, be a target for deep brain stimulation in
we’re just using insecticides blindly”, he the future. “Our work has been an acci-
says. Aurélie Coulon dental discovery. Now we have to carry out
further tests to confirm the result”, says
J. B. Benoit et al.: Unique features of a global Draganski. Atlant Bieri
human ectoparasite identified through sequencing
of the bed bug genome. Nature Communications E. A. Accolla et al.: Deep brain stimulation of
(2016) the posterior gyrus rectus region for t reatment
Immune cells could protect donor organs from resistant depression. Journal of Affective
the rest of the immune system. Disorders (2016)
The brain
Developed at ETH Zurich, the open-source
platform PX4 works like the operating system
of a smartphone. It controls the propellers,
feeds off information from the sensors and al-
lows for the integration of additional m
odules. The limbs
An autopilot enables the drone to reach a Apps can also be added – third-party
destination automatically or hover steadily software designed for a specific task.
on the spot. A ‘follow-me’ app developed in Latvia
instructs the drone to hover at a certain
distance above a GPS receiver worn
by the user. This service was offered
to skiers in Swiss resorts last winter.
Other researchers have used PX4 to
control juggling drones or vertical
landing planes.
The ears
A drone uses a variety of devices to
calculate its position and direction. The
GPS gets signals from satellites; they are
robust but not very precise or fast. The
inertial sensors measure the accumu-
lated movements after take-off. Laser or The eyes
ultrasound altimeters give the elevation. Computer vision is not yet widely used
In special indoor settings, fixed external on commercial drones. Aerial robots
infrared cameras triangulate the position from labs at ETH Zurich were the first
of markers on the drone. to fly using on-board cameras only.
They can reconstruct the shape and
dimensions of objects. “Vision allows
the drone to recognise obstacles and
avoid them. It’s necessary for safety”,
says Lorenz Meier, a PhD student
and the author of the PX4 operating
system. “We will incorporate computer
vision in 2016 by default in PX4-
driven drones”. He has also devel-
oped Pixhawk, a hardware autopilot
running PX4.
Letter to the editor SNSF response: All research supported by the at EFSA. Just as with tobacco and diesel, it seems
SNSF must meet Swiss ethical standards. This scientists are protecting the interests of the plan-
International ethics applies equally to experiments conducted et’s major polluters through a lack of curiosity
I was drawn to the subtitle “Liberties without abroad. The researcher concerned must ob- and with a calm reassurance.
ethical concerns” in the article on China (Beijing’s tain a certificate from the relevant authority in
research gambit, Horizons, March 2016, p. 20). Switzerland – such as an ethics commission or Jean-Pierre Papis, Geneva
What recommendations are given by the SNSF an animal experimentation commission – stat-
to researchers involved in joint work with China? ing that the planned experiments comply with
How do you ensure that money from the SNSF is Swiss legislation.
not funding projects that would not be authorised
in Switzerland? Some doubt
Not only is there no credibility to the position
Marcel Gyger, President of the Vaud Animal expressed by Jose Tarazona of the European
Experimentation Commission Food Safety Authority (EFSA) on the toxicity of
glyphosate (Horizons March 2016, p. 9), but it
also raises doubt about the seriousness of work
Horizons
Martin Vetterli steps down Only few women scientists The Swiss magazine for scientific research
make a career for themselves is published quarterly in German and French.
Volume 28, No. 109, June 2016.
Martin Vetterli, the President of the Na- www.snf.ch/horizonte
tional Research Council of the SNSF, will Although more women than men study
step down after finishing his four-year at Swiss universities, the proportion of Publisher
Swiss National Science Foundation (SNSF)
mandate at the end of 2016 to become the women in professorships is just under 20 Communication Department
President of EPFL. A nomination commis- percent. The Swiss Academies have been Wildhainweg 3
sion led by Gabriele Gendotti will be in investigating the reasons behind this. PO Box
CH-3001 Bern
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on the career situations of young women abo@snf.ch
scientists in the report ‘Einschätzung der
Swiss Academies of Arts and Sciences
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The literary scholar der-equitable academic career paths ought
SNSF/Mauro Mellone
2017–2020 are worrying higher educa- to reproducing any part of this publication.
ISSN 1663 2710
tion and research institutions, including
the SNSF. While the Federal Council has Subscription is free. Distribution of the paper
confirmed core projects, it also sets out version is usually restricted to Switzerland and
foreign organisations.
an intention to allocate a significantly
lower amount to the ERI sector. In a joint The opinions in the articles are those of their
statement, the institutions have expressed authors and do not necessarily reflect those
of the SNSF and/or SA. Research presented is
their fear that the budget cuts will jeop- generally supported by the SNSF.
ardise Switzerland’s leading position in
education, research and innovation. The SNSF
The SNSF is the principal body for the promo-
tion of scientific research in Switzerland. It is
mandated by the Confederation to promote
New NRP approved: Bulgaria and Romania: basic research in all fields and disciplines and
each year distributes some 755 million Swiss
‘Sustainable economy’ 39 completed projects francs amongst more than 3,500 projects
involving about 8,750 scholars.
The SNSF has been mandated by the Over CHF 14 million were awarded to new
The Swiss Academies
Federal Council to conduct the National EU member states under an EU enlarge- Also mandated by the Confederation, the Swiss
Research Programme ‘Sustainable econ- ment contribution programme set up by Academies of Arts and Sciences are committed
omy: resource-friendly, future-oriented, SECO and the SDC. This money contributed to an open dialogue between science and
society. They are on the side of science, each
innovative’ (NRP 73). Its aim is to con- to research on cancer, solar cells, river pol- specialising in a respective domain, yet also
tribute to a more sustainable economy in lution, inter-ethnic relations and educa- acting in an interdisciplinary way. Being
which resources are used more efficiently tion policy. Joint projects were conducted anchored to the scientific community rewards
them with access to the expertise of around
and supply is more reliable. The budget for between Swiss, Bulgarian and Romanian 100,000 researchers.
the five-year programme is CHF 20 million. teams between 2012 and 2016.
A call for proposals will be launched in
June 2016.