If it bleeds...

When you research how to slay a particular entity, tell the GM. An Assassin can
find a way to kill anything - even things that are supposedly immortal and things
that were never really "alive" to begin with - but the GM will give you one to four
of the following conditions:
No mortal could possibly win a head-on fight.
It only has a single, tiny weak spot.
It's only vulnerable at a particular time or place.
It's only vulnerable to a specific weapon or poison.
It's protected by outside forces: you must destroy or subvert these before you can
strike.
Whoever strikes the killing blow will be subject to a terrible curse.
It's in some way integral to the world, killing it will cause havoc.