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scarface

belongs to a subgroup of serine protease homologues with an inactive catalytic


site - functions extracellularly during dorsal closure
as an antagonist of the JNK pathway - regulates the polarized localization of
laminin A during the development of epithelial polarity

scrawny
protein deubiquitinase required in germline, epithelial, and intestinal stem cells
- acts to repress differentiation genes - deubiquitylates histone H2B
and functions in gene silencing - participates in a conserved pathway of
chromatin regulation linking H2B ubiquitylation with H3K4me3 methylation

scribbled
scaffolding protein with multiple PDZ and LLR regions - functions to localize
junctional components in the determination of epithelial cell apicobasal
polarity - acts with discs large 1 and lethal (2) giant larvae to distinguish the
basolateral domain of epithelial cells and neuroblasts - exhibits
antagonistic interactions with the aPKC/Par-6 complex that impacts vesicle
trafficking - organizes synaptic architecture and is implicated in learning and
memory

Tao
Sterile 20 family kinase - a component of the Hippo pathway - restricts cell
proliferation in imaginal discs -
controls of epithelial morphogenesis by promoting Fasciclin 2 endocytosis -
negative regulator of microtubule
plus-end growth - regulation of apoptosis in pole cells

unconventional myosin 10A (preferred name: Myosin 10A)


cytoskeletal motor protein required during dorsal closure for the correct
alignment of cells on opposing sides
of the fusing epithelial sheets and for adhesion of the cells during the final
zippering/fusion phase

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