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scrawny
protein deubiquitinase required in germline, epithelial, and intestinal stem cells
- acts to repress differentiation genes - deubiquitylates histone H2B
and functions in gene silencing - participates in a conserved pathway of
chromatin regulation linking H2B ubiquitylation with H3K4me3 methylation
scribbled
scaffolding protein with multiple PDZ and LLR regions - functions to localize
junctional components in the determination of epithelial cell apicobasal
polarity - acts with discs large 1 and lethal (2) giant larvae to distinguish the
basolateral domain of epithelial cells and neuroblasts - exhibits
antagonistic interactions with the aPKC/Par-6 complex that impacts vesicle
trafficking - organizes synaptic architecture and is implicated in learning and
memory
Tao
Sterile 20 family kinase - a component of the Hippo pathway - restricts cell
proliferation in imaginal discs -
controls of epithelial morphogenesis by promoting Fasciclin 2 endocytosis -
negative regulator of microtubule
plus-end growth - regulation of apoptosis in pole cells