Ve Average marginal cost of care for inpatient stay with hypoglycemic ADE. 3 1% Overall cost of care for inpatient stay with hypoglycemic ADE. MARGINAL COSTS Of nearly 30 million hospital discharges in 2013, an estimated 600,991 adverse drug events* involving a hypoglycemic agent resulted in an average marginal cost of $4,312. The Agency for Healthcare Research and Quality (AHRQ) study reporting these figures also found that an adverse drug event involving a hypoglycemic agent added 31 percent to the overall cost of care for an inpatient stay, ranging from a marginal cost of $2,747 for heart failure to $9,054 for major surgery. Furthermore, the study showed a 9,7 percent probability of an adverse drug event for any patient exposed to a hypoglycemic agent.