Bone pathology:

 Disorganized LAMELLAR bone in a MOSAIC pattern = Paget’s disease

o
 Osteoid MATRIX accumulation AROUND TRABECULAE = vitamin D deficiency
(osteomalacia / Rickets)
o

o
 Primary spongiosa persistence in the MEDULLARY CAVITY with NO MATURE
TRABECULAE = osteopetrosis:

o
 o
 Trabecular THINNING with FEWER INTERCONNECTIONS = osteoporosis:
 o
 Thinning of CORTICAL BONE with PRESERVED TRABECULAE = primary
hyperparathyroidism
o Progression to eventual trabecular involvement
o Eventual formation of brown tumors = hemosiderin deposition due to
hemorrhage:


o Lastly, progresses to osteitis fibrosa cystica (von Recklinghausen disease of
bone) -> cysts + hemorrhage in bone: