UNIVERSITY OF SANTO TOMAS FACULTY OF MEDICINE AND SURGERY MEDICAL BOARD REVIEW: DEPARTMENT OF MEDICAL EDUCATION PHARMACOLOGY MOCK EXAMINATION NAME: CODE: GENERAL INSTRUCTIONS: This questionnaire is composed of 100 items. On the box Provided in the front page of the Examination Answer Sheet, kindly write your name. All final answers should be made on the back page of the EXAMINATION ANSWER SHEET that is provided for. Only Mongol 2 may be used. Do not leave any blanks as this will be considered incorrect. Submit your answer sheet. Please be guided accordingly. (CHOOSE THE BEST ANSWER: 1. ____This drug lowers blood pressure by blocking alpha receptors in the smooth muscle of peripheral arteries: A. labetalol «. B. esmolol A: C., prazosin fonicine DO methyldopa Lentally ach sympothopleqie —>sutmpa onttlon fr, Vescrnctsr Lenton of BS 2, ____ Increases lipolysis of triglycerides rough ligand binding at PPAR-a: ‘A. cholestyramine -LDL , head binding rset B. fenofibrate ~Roni add dtrivakive ; PPAR® ligand C. niacin -LOL, by inh. of VLDL secretion D. atorvastatin -LOL , He on eeductue inn. (mediator of I step in cha 3. ___ The following electrolyte abnormality increases the isk for diaitallstoxicty: A. hypocalcemia -huper Ca” “ath: Nak Arpast: B. hypermagnesemia - hypo mg" CC. hypokalemia = K + Dijibnlu mh: cack other, bincking m Nak ArPate 'D. hypernatremia -no effec 4. ____A65 year old male who is taking anti-CHF (congestive heart failure) medication,s, complains of nausea and vomiting. This is an early sign of toxicity to: A. catvedilol =brady, welening of astrmer, vinil detame, fatique B. digoxin C. spironolactone - hyper kt, hyperfittemic metab acidau D. captopril - dry conan, angive ctemmer biasynth) 5. ___ First line agent for patients with congestive heart failure and pulmonary edema: A, furosemide B. digoxin - CHF of AF C. nitroglycerine > varochilatom, fr angina D. nifedipine 6. ____ Which of the following antihypertensives is absolutely contraindicated in pregnancy? A, atenolol ‘AcE (peas B. captopril 7 store ne C. prazosin i = fetal lat hy poeson D. methyldopa -for HN in preqnanuy 7. ____ This drug lowers plasma lipoprotein concentration by inhibition of HMG CoA Reductase: A. lovastatin B. nicotinic acid C. dofibrate D. cholestyramine USTFMS MEDICAL BOARD REVIEW 2018 : Page 1 of 12\n executive was diagnosed to have chronic stable angina. Which of the following os preparations is the best choice to prevent recurrent anginal attacks? A sosorbide dinate sublingual need selief B, Isosorbide mononitrate ol. sun): -hlecmee | 5 eer apf Mor wmv Nac ni Hide 9. __A.60 year old with CHF and bipedal edema was given a dluretic. He comes back a, ~~ week later complaining of lower extremity weakness. His serum K+ levels low.and his, - ECG showed frequent PVC’s, Which diuretic was most likely given? ne A. Eplerenone - K* sparing C. spironolactone terte B. Furosemide + k* faouing D. amiloride 10.__ Which of the following is ultra-short-acting hence, useful in hypertensive emergency and acts by releasing nitric oxide? A. hydralazine ~ 7¢hrs . nitroprusside: sezonds vw nicardipine -4-iia ). nitroglycerine Iv - it. Mechanism of action of hydralazine: ; Diawovide A. hyperpolarization leading to relaxation of smooth muscle by Promoting K efflux through activation of ATP modulated K channels Na Niopnasict, MB. acts by releasing nitric oxide ae ¢¢Bs C. ‘block voltage dependent calcium channels D. direct relaxation of arteriolar smooth muscle due to fall in intracellular Ca+-+ concentration 12. ___ The development of tolerance is seen with’the following if used for more than 8 hours without interruption: ©. Vieleaied of NO aft A. verapamil B. aspirin 8 seem cowptroton Cig ey Caen © gtrvccton ob supers redival | 13.___ This class of ipid lowering drugs has been shown to stabilize atherosclerotic plaques: ‘A. niacin B. fibric acid derivatives C. HMG-CoA reductase inhibitors D. bile acid binding resins 14,___ A 60 year old male patient, diagnosed to have dilated cardiomyopathy in congestive heart failure, needs this drug to improve his hemodynamics through decrease. in reload and afterload: : A. furosemide B. metoprolol C. digitalis D. captopril 15.___ This agent acts by reducing the viscosity of blood, hence its usefulness in the treatment of peripheral artery disease: ‘A. ranolazine -redwies lake Ma channel B. clopidogrel - prey ADP mdwecl pit ogg: & Wabradine - selective IF Na locker j Modes pattmaker (5A rack )-LHR ufo be, D. pentoxifylline : 4 16. —__ A 70 year old female complained of palpitations without other accompanying symptoms. PR=140-150/min, regular. Which of the following reduces the cardiac ate by inhibiting the hyperpolarization-activated sodium channel in the SA node without causing any other significant hemodynamic effects: ‘A. ranolazine : B. metoprolol C. ivabradine 5 D. trimetazidine oh. FFA eudiahon mv mypendiom - anhengina remec USTFMS MEDICAL BOARD REVIEW 2018 * Page 2 of 1117. a ae oo ome fac Post ee if successful reperfusion is & nahn pean fe rains ty prmolt pH. 099- 18 woe et coe a are ot AE aan € tee errecemanoee 19. __This drug is beneficial in pati ihe myocardium to glucose eutenct® Mtn angina by shifting free fatty acd oxidation in Wes 10 Os pee BFP produced bes myocarchal Or reqtts ‘A. nicorandi B. nifedipine C. trimetazidine D. captopril ©. Which othe flowing has B1 = B2 > a1 > a2 receptors selectivity? | prazosin oc : : A ei aie den ae C. epinephrine D. metoprolol - 1 2 is a common side effect of this antihypertensive: cb a ee hapokal , hyperuricemia, hypergly (mpareol pelacee of sroulin), —, C. losartan - dry comgh D. hydralazine - refi toy, Plasing , sera 22. ‘This diuretic can worsen diabetic control; 27" """"9. "™ A. furosemide B, ethacrynic acid C. hydrochlorothiazide D. spironolactone 23, ____ In addition to a rapid acting bronchodilator, this felievé} should be given to quickly reduce the marked inflammatory changes and mucus production’in the airway so as to ! \ i 2 reverse a severe asthma exacerbation: A. montelukast B. prednisone C, theophylline ~reliewer + vontelher D. ipratropium - not antintlan (ant ckainergic) 24.___ BLL,, 30 years old, developed acute severe angidedema of eyes, lips ‘and face with increasing respiratory distress, choking Sensation and hypotension minutes after the intake of Jhuprofen. Which drug should be given immediately to relieve his distress? Gnaphylatoid ~ nonlgé mediated A. diphenhydramine B. epinephrine C. nebulized salbutamol D. montelukast -no} for araPrylactic rans ;leuksbiere antag may help in roshlenantt Phase tals 25.__ Which of the following asthma controllers acts as mast cell stabilizer? A. theophyline #0E inh. B. cromolyn » C. montelukast - éF inh- D. ipratropium - antimuscarinic 26.___ This agent is very effective for aspirin-induced asthma and an alternative maintenance medication for mild asthma and allergic rhinitis: ‘A. Theophylline -maint for oamnia only C. cromolyn sodium B. Montelukast D. inhaled corticosteroid? asthma AR - intranasal OS USTFMS MEDICAL BOARD REVIEW 2018 Page 3 of 12