The typical gas-liquid contacting operations include distillation, absorption, stripping,
leaching and humidification. Distillation and absorption are two most widely used mass transfer processes in chemical industries also can be categorized as pressure vessel. Chemical design of plate column for absorption and distillation involves many common steps of calculation such as determination of number of theoretical plates, chemical reaction which includes mass balances and energy balances. Meanwhile, material and mechanical design of distillation column involves series of calculation such as design pressure, design temperature, selection of material of construction, vessel thickness, heads selection and thickness, total dead weight loads of vessel, wind loading, dynamic wind pressure, seismic loading, critical buckling stress, stiffening ring requirement and lastly vessel support design. This report outlines the material and mechanical design of reactive distillation column (T-100) for production of 65, 000 MTPA of methyl tert-butyl ether (MTBE) at high purity. The summary to the design conditions are as follows: