Pathogenesis of COPD Eve Wong
Sen ove Oca 2008282014288,
COPD arses tam entonmanil xpsue,patcull eign scing, gently suscep nda. Sth emphystna and
‘trans bene ae rom smi pathogen mechanisms
NP ASEU: Smoking causa infsmation nhs aye. Noto and ter mune cls ar recite othe sal sinye ales
Proteases anf odie speci. Nevo atase tena dou lst es that nara crtes bees eel dure
‘oraton. al artypsin isa pote hiber that kes esas acy in heck d-ab pin fiery ie best en ene
Predspaiion emphysema, cps in snakes wh hs geet dower paved ges xchange and a Vang areas aus of
nase,
180 ONC: nmin rar sme xpi as cass Raf the tener wal. mucus hyperereton, way ee,
ra benchecnstctan Tres tues make up te sal way asco compere COPD, kom a een one
cenenc NVRONMENTAL Risk factors
‘Smoking
Biomass burning
Occupational exposure
deficiency
Loss ofa antnpsin ests ¥
‘unopened raha
‘savin fne by osetce
Inflammation
Recritrent of neatophis to Squamss call metas,
‘rorciles and sec ‘rat steel
¢ EC
T oxidative tess,
inflammatory
smeciators, cytokines
1 neutrophil elastase and
matrix metalloproeinases
Mucus hypersecretion
Ciary dystunction
Y
Desriton a Fibrosis and aera an
slveir walls and thickening ofthe || smonth muscle
canaries bronchiolar walls ‘ontetion
ae ‘as a
Erlared air | | imoaived gas | | Air tapsire
spaces diffusion ‘on expiration Pre er ereee
7
[comin —]—, oman J Any sce
imeretatin
Emphysema Chronic bronchitisPathophysiology of COPD Eve Wong
‘Te cle fears of COPD ean te sma into emphysens and eveic Leechs phates. Homers mast pats wal hve 2
‘nix eeraon wth eats om bth prentype=
ENPREEU: To “pink puto is a thin, cachet person with mata shortness of rst, Wh emphysara, ths lod remains lately
‘elonjgerted Beas bth att stl pes we route, lesa ced Va delet Lan ast es ess
Stu spo fr lel nd salsa, ch makes hem pronto clap cr expaton ang a raping, Pep
[eating als malrtrance of ast ereagaaypressute(PEEP, ach Megs De way pe. The dctease ag camplarce
‘eas trend wat bag ad pte,
(1BONC ROACH: The "le seri age, edematous parson with anos nd relate sane. Away ion ds
hypaca, wa mismatch and subseqvebypumenary vasocnscton. ag esstanee te piney vascltre (pulmonar
Fypertan) caves) reduced eating Mood volume ti ihe eat ale, whch can progres co uae
rematch ioe fe poms and ployer, whic rests reno
Emphysema Crone bronehits
PINK PUFFER LUE BLOATER|
t Y 4 1 4
T lung, Destruction of Air trapping Airway ee
compliance capillary bed ‘on expiration obstruction hypersecretion
T Le heed
smc —— | pn wn i - t ne
“te ‘Avedlar—|,oeen reductive ough with
Matched typora [Piatt "Sapo pute
V0 cetect tot
y aa ¥ +
Relatively wee : Pulmonary
oxygenated V0 mismateh ff Z
until late stage ponent
_ ay et clspeceay |
monary twpeterson
breathing Hypoxemia || Hypercarbia. Posmonaty Weer
1 vada Lie
, 4 y y ’ :
Dyspnea Catenin Osteoporosis Heat ease apo | Pee 2
fianiod 4 rovemeni HT Secas” || vou || puneraie
Tianaton rm + y
Fonte fanatic] NP
fans. | Lowa P2
Parastenl
Tegnima — Aayimobenet—Wakioer Ugh Ter oe wo a pet y tea
fuga tenes iene 9) Ses, | ruldetention Perper
Caracas aad as) posterar stesplsacrad wns edema
Mrs soces —a-antypain at teenie tha
Pamaciat cling avec ‘tfceny BH _anbitrypindefcincy.