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Pathogenesis of COPD Eve Wong Sen ove Oca 2008282014288, COPD arses tam entonmanil xpsue,patcull eign scing, gently suscep nda. Sth emphystna and ‘trans bene ae rom smi pathogen mechanisms NP ASEU: Smoking causa infsmation nhs aye. Noto and ter mune cls ar recite othe sal sinye ales Proteases anf odie speci. Nevo atase tena dou lst es that nara crtes bees eel dure ‘oraton. al artypsin isa pote hiber that kes esas acy in heck d-ab pin fiery ie best en ene Predspaiion emphysema, cps in snakes wh hs geet dower paved ges xchange and a Vang areas aus of nase, 180 ONC: nmin rar sme xpi as cass Raf the tener wal. mucus hyperereton, way ee, ra benchecnstctan Tres tues make up te sal way asco compere COPD, kom a een one cenenc NVRONMENTAL Risk factors ‘Smoking Biomass burning Occupational exposure deficiency Loss ofa antnpsin ests ¥ ‘unopened raha ‘savin fne by osetce Inflammation Recritrent of neatophis to Squamss call metas, ‘rorciles and sec ‘rat steel ¢ EC T oxidative tess, inflammatory smeciators, cytokines 1 neutrophil elastase and matrix metalloproeinases Mucus hypersecretion Ciary dystunction Y Desriton a Fibrosis and aera an slveir walls and thickening ofthe || smonth muscle canaries bronchiolar walls ‘ontetion ae ‘as a Erlared air | | imoaived gas | | Air tapsire spaces diffusion ‘on expiration Pre er ereee 7 [comin —]—, oman J Any sce imeretatin Emphysema Chronic bronchitis Pathophysiology of COPD Eve Wong ‘Te cle fears of COPD ean te sma into emphysens and eveic Leechs phates. Homers mast pats wal hve 2 ‘nix eeraon wth eats om bth prentype= ENPREEU: To “pink puto is a thin, cachet person with mata shortness of rst, Wh emphysara, ths lod remains lately ‘elonjgerted Beas bth att stl pes we route, lesa ced Va delet Lan ast es ess Stu spo fr lel nd salsa, ch makes hem pronto clap cr expaton ang a raping, Pep [eating als malrtrance of ast ereagaaypressute(PEEP, ach Megs De way pe. The dctease ag camplarce ‘eas trend wat bag ad pte, (1BONC ROACH: The "le seri age, edematous parson with anos nd relate sane. Away ion ds hypaca, wa mismatch and subseqvebypumenary vasocnscton. ag esstanee te piney vascltre (pulmonar Fypertan) caves) reduced eating Mood volume ti ihe eat ale, whch can progres co uae rematch ioe fe poms and ployer, whic rests reno Emphysema Crone bronehits PINK PUFFER LUE BLOATER| t Y 4 1 4 T lung, Destruction of Air trapping Airway ee compliance capillary bed ‘on expiration obstruction hypersecretion T Le heed smc —— | pn wn i - t ne “te ‘Avedlar—|,oeen reductive ough with Matched typora [Piatt "Sapo pute V0 cetect tot y aa ¥ + Relatively wee : Pulmonary oxygenated V0 mismateh ff Z until late stage ponent _ ay et clspeceay | monary twpeterson breathing Hypoxemia || Hypercarbia. Posmonaty Weer 1 vada Lie , 4 y y ’ : Dyspnea Catenin Osteoporosis Heat ease apo | Pee 2 fianiod 4 rovemeni HT Secas” || vou || puneraie Tianaton rm + y Fonte fanatic] NP fans. | Lowa P2 Parastenl Tegnima — Aayimobenet—Wakioer Ugh Ter oe wo a pet y tea fuga tenes iene 9) Ses, | ruldetention Perper Caracas aad as) posterar stesplsacrad wns edema Mrs soces —a-antypain at teenie tha Pamaciat cling avec ‘tfceny BH _anbitrypindefcincy.

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