c2) United States Patent Leung et al. US006596298152 US 6,596,298 B2 Jul. 22, 2003 (10) Patent No.: 43) Date of Patent: 6 05) 0) en @) (6) (oo) (1) (2) (8) FAST DISSOLVING ORAL FILMS Y COMSUMABLE, Inventors: Sau-Hung Spence Leung, Parsippany NJ (US); Robert S. Leone, Fanivood, NJ(US}; Lori D. Kumar, Skillman, NJ (vs) Assignce: Warner-Lambert Company, Morris Plains, NI (US) Notice: This patent issied on continued pros ccution application filed under 37 CFR 1F53¢), ais subject to the weaty year patent term provisions of 35 USC. 1540)2) Subject any disclaimer, the term ofthis patent is extended or adjusted under 35, USC. 1540) by 0 days Appl. No. 09/398,104 Fike; Sep. 14, 1999 Prior Publication Data Related U.S. Application Data Provision application No, 010,798, filed on Sep. 25, Im. Cl? AGIK 724; AGIK 9/705 "A6IM 37/00 us.cL 424/488; 424/49; 49455; 424405; 124407, 424/410; 42414395 4247441; 2A, 424444 Fleld of Search 424/404, 434, 3244435, 405, 407, 410, 443, 439, 441, 44,49, 55, 60) References Cited US. PATENT DOCUMENTS, SAWS A 571960 Rossel (List continued om next page.) FOREIGN PATENT DOCUMENTS. ca 11300 cy retest 21093 (List continued om aext page.) OTHER PUBLICATIONS Shi, Frederick P; “Edible films trom rice protein eoncen- trate and pulluan."; Cereal Chemistry, vol. 73, No.3, 1996; pp 406-09. Edible Films Solve Problems; Food Technology; vol. SL, No. 2; Feb. 1997; pp. 60-74 Primary Exaniner—Teurman K. Page (14) Attomey, Agent, or Firm-—Evan J. Federman; Darryl CLitte on ABSTRACT Physiologically aceptable films, including edible fms, sce lsclosed. The films include a wuter soluble film-forming polymer such as pullulan. Edible films are disclosed that fnclude pullulin and antimirobially effective amounts of the essential oils thymol, methyl salicylate, eucalyptol and menthol. The edible films ae effective st killing the plaque= producing germ that cause dental plague, gingivitis and ad. breath, The film ean also contain pharmaceutically active agents. Methods for producing the flim are also disclosed 20 Claims, 2 Drawing SheetsUS 6,596,298 B2 age? US, PATENT DOCUMENTS » coor anger ? ost 3aU300 A 41974 Psp eta, on 48 au S2@ A assy shaceaeger al” Ip coors 191s ieee A gee cea pss ‘suse A —— - smite tStom & Stn B esss ais tates A Tie 5,023,082 A Friedman et al. ayaa JP 63310818 12988 Soraat a Saori a ” basaiey tt Sosteis A + 2idot Gmutase owen JP soot ‘tnons Soetssr A Siu i» Saag aes Sires A Ont ” sawsss om Sots A Oral fd wowet Base Sem A Monon ” Deut son? Stans A= 127 Beppe ne 24684 TP Staiger Shatsio A foes Giis Wo woman ums Soins A + S000 fate eh Shes Wo Nossa Wo Most FOREIGN PATENT DOCUMENTS Mo oes Wo Woosanes we osistt 21088 i visisse Stone wo woos one poor : ; z cms wo woos “ano f omsess “anon * eed by examineeU.S. Patent Jul. 22, 2003 Sheet 1 of 2 US 6,596,298 B2 FIG-t