III2B - NanoRam General Presentation KAM 4-2-13 - KB

NanoRam
Handheld Raman Spectrometer

Keegan A. McHose
Regional Sales Manager
1
www.bwtek.com | www.nanoram.com
We are Your Spectroscopy Partner
Global leader with > 10,000 Portable and handheld Raman systems
B&W Tek, China

B&W Tek, Corporate Headquarters
Ming Shen Commercial Plaza
19 Shea Way Newark, DE 19713, USA
400 CaoBao Rd., Suite 2206, Shanghai -
Phone: +1-302-368-7824
200233, China
Web: www.bwtek.com
Phone: +86 021-64515208
B&W Tek, Europe
B&W Tek, Japan
Seelandstraße 14-16, 23569 Lübeck,
2-3-2 7F, Kamiochiai, Chuo-ku, Saitama-city,
Germany
Saitama - 338-0001, Japan
Phone: +49(0)45130803854
Phone: +81(0)48 851 3150
www.bwtek.com | www.nanoram.com 2
Raman Spectroscopy
Laser
785 nm Excitation
1 photon : 1,000,000
3
Mid-IR NIR reflectance Raman
Mechanism: absorption by Mechanism: absorption by Mechanism: inelastic
fundamental molecular harmonics of fundamental scattering by vibrational,
vibrational modes vibrational modes of X-H bonds rotational, low frequency
(e.g., N-H, O-H) molecular modes.
Molecular Specificity: high
Molecular Specificity: low Molecular Specificity: high
Signal Strength: strong
Signal Strength: weak Signal Strength: weak
Energy: 600-4000 cm-1
Energy: 4000-12,500 cm-1 Energy: 176-3200 cm-1
Sampling: direct material
contact required, glass and Sampling: non-contact, but Sampling: container
water appear opaque; can close proximity to material interference is mitigated by
rarely see through container required (<5 mm) accessories
materials
Hardware: longer probes Hardware: CCD detection;
Hardware: probes extremely possible (meters); quartz optics; quartz optics; long probes
expensive, and short in length, dispersive, interferometry common (kilometers in some
size and weight common cases)
4
Technical Specifications
NanoRam
BWS455
Detector TE Cooled linear CCD Array
Excitation 785nm ± 0.5nm, Stability <0.5cm-1, Linewidth <2.0cm-1
mW tunable from 0 mW to 300 mW
Laser Power
0 to 100% in 10% increments
Control
Range / 176cm-1 to 2900cm-1
Resolution ~ 9.0 cm-1 @ 785nm
Display High Visibility OLED touch screen, 3.7" size
Barcode Reader 1D and 2D barcodes
Data Formats .txt, .csv, .spc
DC Power 12V DC at 6.6 Amps
Battery Rechargeable Li-ion Battery, > 5 hours operation
PC Software NanoRam ID
Computer
USB 2.0, Wifi
Interface
5
NanoRam
Raman Technology
 Optimal excitation
wavelength of 785nm to
reduce fluorescence
 Complies with USP<1120>

and EP Ch.2.2.48 guidelines
for Raman spectroscopy
 Accepted cGMP analytical

testing method to replace
wet chemistry: ICH Q2 R1
NanoRam
Innovations
 State of the art laser and
cooled sensor technology
increases sensitivity
 Open software design for

third party software
applications
 Transfer libraries from

instrument to instrument
easily
7
NanoRam
Lean Material Lifecycle
 Incoming non-destructive
testing of Raw Materials
 Reducing Waste in the
Dispensing Suite
 Plastic Packaging
Identification
 At line identification of
intermediates
 Final product identification
 Substandard, Adulterants, and Counterfeit Deterrent
8
NanoRam
Ease of Use
 No sample preparation
required
 Scan through:
 Polyethylene Bags
 Borosilicate Glass
Vials
 Disposable Pipette
 Touch Screen allows for
quick documentation of
sample information
9
NanoRam
Ease of Use
 Performance Qualification
using polystyrene takes less
than one minute
 Wireless reporting for
reduced documentation lead
time
 Remote Administration to
reduce unit down time
 Clear Pass/ Fail results
 Attachments provide laser
safety with built in interlock
10
NanoRam
Good Documentation Practices
 Fully Traceable results with:
 Time/ Date Stamps
 User
 System Presets
 Etc.
 Personalize to your company

reporting preference with NID
 Reported to a secure database

that can be linked to your LIMs
NanoRam
Technical Support
 IQOQPQ Services
 Execution
 Validation Documentation
 SOP Templates
 Admin
 Developer
 General User Training
 On-site method development,
training and other support services
available
 Customer support 24/7 Phone Line
12
NanoRam
Regulatory Compliance
 Supports CFR21 Part 11 Electronic
Records and Signature Protocols
 Supports CFR21 Part 1040.10
Performance Standards for Light
Emitting Products
 Complies with USP<1120> and EP
Ch.2.2.48 guidelines for Raman
spectroscopy
 ASTM E1840 Raman Shift Standards
for spectrometer calibrations
13
NanoRam
Warranty Programs
 One year factory
warranty comes standard
 Extended warranty
programs of 2 or 3 years
can be additionally
purchased
 All warranties can be
combined with calibration
service
14
15

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NanoRam

Handheld Raman Spectrometer

B&W Tek, China

 Complies with USP<1120>

 Accepted cGMP analytical

 Open software design for

 Transfer libraries from

 Personalize to your company

 Reported to a secure database

 Customer support 24/7 Phone Line

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