Renal Pathology 1

Dr Mohit Shahi
• Acute pyelonephritis
• Chronic pyelonephritis
 Acute pyelonephritis
• Grossly
– Normal or Enlarged, swollen kidney
– C/S – Abscesses -small yellow-white with
hemorrhagic rim, Mainly in cortex
• Microscopy
– Acute inflammation – Interstitium and destruction
of tubules
– Glomeruli and blood vessels – Spared
– Sheets or focal abscesses of neutrophils
 Chronic pyelonephritis
• Gross
– Small, asymmetrically, contracted kidney
– <100 g
– Surface – Irregularly scarred, and cortical
depressions
– Dilated pelvis, blunted calyces
• Microscopy
– Interstitium – Chronic inflammation, lympho,
plasma, macro and fibrosis
– Tubules – Atophy, dilation, thyroidisation
– Pelvicalyceal system – Inflammation, scarring
– Glomeruli – Peri-glomerular fibrosis, hyalinisation
Irregularly Scarred Contracted Kidney