acvr1

 Official Full Name

 activin A receptor, type I

 Background
 Activins are dimeric growth and differentiation factors which belong to
the transforming growth factor-beta (TGF-beta);superfamily of
structurally related signaling proteins. Activins signal through a
heteromeric complex of receptor;serine kinases which include at least
two type I ( I and IB) and two type II (II and IIB) receptors. These
receptors;are all transmembrane proteins, composed of a ligand-binding
extracellular domain with cysteine-rich region, a;transmembrane domain,
and a cytoplasmic domain with predicted serine/threonine specificity.
Type I receptors are;essential for signaling; and type II receptors are
required for binding ligands and for expression of type I;receptors.
Type I and II receptors form a stable complex after ligand binding,
resulting in phosphorylation of type I;receptors by type II receptors.
This gene encodes activin A type I receptor which signals a particular
transcriptional;response in concert with activin type II receptors.
Mutations in this gene are associated with fibrodysplasia;ossificans
progressive.

 Synonyms
 ACVR1; activin A receptor, type I; ACVRLK2; activin receptor type-1;
ACVR1A; ALK2; SKR1; activin receptor type I; hydroxyalkyl-protein
kinase; activin receptor-like kinase 2; TGF-B superfamily receptor type
I; activin A receptor, type II-like kinase 2; se

 Recombinant Proteins

 Cell & Tissue Lysates

Source
Cat.# Product name (Host) Species Tag Price

ACVR1- Recombinant Human HEK293 Human MYC/DDK

+Inquiry
1022H ACVR1 Protein,
MYC/DDK-tagged
 Source
Cat.# Product name (Host) Species Tag Price

ACVR1- Recombinant Human HEK293 Human His/Fc

+Inquiry
527H ACVR1 Protein, His/Fc-
tagged

ACVR1- Recombinant Human Sf 9 Insect Human

+Inquiry
01H Activin A Receptor, cells
Type I

ACVR1- Recombinant Human Baculovirus- Human N/A

+Inquiry
1408H Activin A Receptor, Insect Cells
Type I

ACVR1- Recombinant Human NS0 Human N/A

+Inquiry
1583H Activin A Receptor,
Type I

ACVR1- Recombinant Human Baculovirus- Human His

+Inquiry
199H ACVR1 Protein, His- Insect Cells
tagged

ACVR1- Recombinant Human Sf 9 Insect Human GST

+Inquiry
201H ACVR1(R206H), GST- cells
tagged

ACVR1- Recombinant Human Sf 9 Insect Human GST

+Inquiry
239H Activin A Receptor, cells
Type I, GST-tagged,
Active

ACVR1- Recombinant Human Insect Cell Human GST/His

+Inquiry
245H ACVR1 Protein, GST-
His-tagged
 Source
Cat.# Product name (Host) Species Tag Price

ACVR1- Recombinant Human Insect Cell Human GST

+Inquiry
246H ACVR1 Protein, GST-
tagged

ACVR1- Recombinant Human Wheat Germ Human GST

+Inquiry
247H ACVR1 Protein, GST-
tagged

ACVR1- Recombinant Human BTI-Tn-5B1-4 Human N/A

+Inquiry
2595H Activin A Receptor, cells
Type I

ACVR1- Recombinant Human Nicotiana Human N/A

+Inquiry
2743H Activin A Receptor, benthamiana
Type I

ACVR1- Recombinant Human ALK2 Sf 9 Insect Human GST

+Inquiry
32H (Q207D), GST-tagged cells

ACVR1- Recombinant Human ALK2 Sf 9 Insect Human GST

+Inquiry
33H (Q207E), GST-tagged cells

ACVR1- Recombinant Human Sf 9 Insect Human GST

+Inquiry
37H ACVR1, GST-tagged cells

ACVR1- Recombinant Human ALK2 Sf 9 Insect Human GST

+Inquiry
38H Mutant (Q207E), GST- cells
tagged

ACVR1- Recombinant Human HEK293 Human Fc

+Inquiry
489H Activin A Receptor,
Type I, Fc Chimera
 Source
Cat.# Product name (Host) Species Tag Price

ACVR1- Recombinant Human Human cells Human Fc

+Inquiry
526H ACVR1, Fc-tagged,
Biotinylated

ACVR1- Recombinant Human E. coli Human His

+Inquiry
5680H ACVR1 protein, His-
tagged

ACVR1- Recombinant Human E. coli Human His/GST

+Inquiry
5681H ACVR1 protein, His &
GST-tagged

ACVR1- Recombinant Human Baculovirus- Human

+Inquiry
9172H ACVR1 Insect Cells

Acvr1- Recombinant Mouse E. coli Mouse His

+Inquiry
5682M Acvr1 protein, His-
tagged

Acvr1- Recombinant Mouse HEK293 Mouse FC/His

+Inquiry
775M Acvr1, Fc-His tagged

Acvr1- Recombinant Rat Acvr1, HEK293 Rat Fc

+Inquiry
8719R Fc tagged

ACVR1- Recombinant Cynomolgus HEK293 Cynomolgus Fc

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8812C ACVR1, Fc tagged Monkey

ACVR1- Recombinant Rhesus Mammalian Rhesus His

+Inquiry
230R monkey ACVR1 Protein, Cells Macaque
His-tagged
 Source
Cat.# Product name (Host) Species Tag Price

ACVR1- Recombinant Canine HEK293 Canine Fc

+Inquiry
160C ACVR1, Fc-tagged

ACVR1- Recombinant Canine HEK293 Canine His

+Inquiry
161C ACVR1, His-tagged

ACVR1- Recombinant Canine HEK293 Canine FC/His

+Inquiry
300C ACVR1, His tagged

ACVR1- Recombinant Canine HEK293 Canine His

+Inquiry
301C ACVR1, Fc tagged

ACVR1- Recombinant Chicken Mammalian Chicken His

+Inquiry
6129C ACVR1 Cells

ACVR1- Recombinant Human Sf 9 Insect Human GST

+Inquiry
984H Activin A Receptor, cells
Type I, His-tagged

Involved Pathway

ACVR1 involved in several pathways and played different roles in

them. We selected most pathways ACVR1 participated on our site, such
as Cytokine-cytokine receptor interaction, TGF-beta signaling
pathway, Signaling pathways regulating pluripotency of stem cells,
which may be useful for your reference. Also, other proteins which
involved in the same pathway with ACVR1 were listed below. Creative
BioMart supplied nearly all the proteins listed, you can search them
on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CCR3; KITB; PF4; IL3; CCL25; IL11RA2; TP-1; CCL21; IFNA5; IFNK
TGF-beta signaling pathway
NOG3; BMP8A; SMURF1; RPS6KB1B; TNF; TGFB3; PPP2CA; ROCK2B; TGFB2;
ZFYVE16
Signaling pathways regulating pluripotency of stem cells
NANOG; MAPK13; SMARCAD1; WNT7B; HAND1; PIK3R2; ID4; NRAS; SMAD9; MYF5

Protein Function

ACVR1 has several biochemical functions, for example, ATP binding,

SMAD binding, activin binding. Some of the functions are cooperated
with other proteins, some of the functions could acted by ACVR1
itself. We selected most functions ACVR1 had, and list some proteins
which have the same functions with ACVR1. You can find most of the
proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PC; AURKC; PSMC4; PKN1B; ABCD4; CDKL5; PARS2; PAK1;
MASTL; BRAF
Function SMAD binding
Related Protein BMP2; STUB1; TOB1; PRDM16; SOD3; HIPK2; SKILB;
SKOR1; YY1; HMGA2
Function activin binding
Related Protein ENG; FKBP1A; TGFBR3; ACVRL1; ACVR2B; SMAD7; FST;
ACVR1; FSTL3; SMURF1
Function contributes_to activin receptor activity, type I
Related Protein ACVR1; ACVRL1
Function metal ion binding
Related Protein KCNIP3A; CDH24; ADPRM; ZNF574; LIMCH1B; INSM1A;
ZFP39; ZNF791; ZNF100; CAHZ
Function peptide hormone binding
Related Protein GALR2; HCRTR2; AVPR1A; ACVR1; MC4R; HCRTR1; GCGR;
CRHR2; ECE1; AGTR1A
Function protein binding
Related Protein ASF1B; HAAO; FGA; REG3A; DIS3; USP9X; CCHCR1; GPS1;
NDOR1; ARRB2
Function protein homodimerization activity
Related Protein SMAD3; Il6ra; S100A1; TRIM8; TNNC1; PDE2A; APOBEC3G;
PRMT2; NAMPT; MTERFD3
Function protein kinase activity
Related Protein NEK2; TRIM28; PRKDC; ACVR1BA; GM711; CSNK1G3; PKN2;
NLK2; STK38A; STK4
Function protein serine/threonine kinase activity
Related Protein CSNK1DB; HIPK4; PRKD2; SLKA; FASTK; STK35; STK19;
PAK1; PDIK1L; GSK3B
Function receptor signaling protein serine/threonine kinase activity
Related Protein BMPR2B; ACVR1C; ALPK2; ACVRL1; ACVR1L; TGFBR1;
ACVR1; BMPR1AB; BMPR1BA; BMPR1AA
Function transforming growth factor beta binding
Related Protein THBS1; CD109; ENG; ACVR1; ACVRL1; HYAL2; LTBP4;
TGFBR3; TGFB3; LTBP1
Function transforming growth factor beta receptor activity, type I
Related Protein TGFBR1; ACVR1; BMPR1B
Function transmembrane receptor protein serine/threonine kinase
activity
Related Protein BMPR1BA; ACVR1L; ACVR1BA; ALPK2; BMPR2B; ACVR1;
ACVRL1; BMPR1B; BMPR1AB; BMPR1BB

Interacting Protein

ACVR1 has direct interactions with proteins and molecules. Those

interactions were detected by several methods such as yeast two
hybrid, co-IP, pull-down and so on. We selected proteins and
molecules interacted with ACVR1 here. Most of them are supplied by
our site. Hope this information will be useful for your research of
ACVR1.
Smad6; Rab17; Rhod; Fbxo30; Ikbkb; Chn1; Nek8; Ubxn1; Fancl; Rab3b;
Rhebl1; Plekhb1; TGFBR1; linkable pd173955 analogue; bosutinib;
dasatinib; crizotinib