Risk Factors: Actual Factors:

-Genetic Predisposition -Alcohol Ingestion

-Fat -Family history of Diabetes Mellitus- genetic predisposition such as
diabetes mellitus can cause cholangitis since the body cannot
-Female
anymore use glucose as their energy source as a part of
-Fertile compensatory mechanism they use fats and proteins which may lead
-Forty to the acid-base imbalance in the body’s system. Thus it may lead to
-Diabetes Mellitus the consumption of proteins leading to proteinuria.
-Alcohol ingestion

The liver will secrete bile that’s abnormally high in

cholesterol or lacking the proper concentration of bile
salts. The solutes must precipitate from solution as solid
crystals. crystals come together and fuse to form stones.

Gallbladder concentrates the bile

Cholesterol,calcium, and bilirubin

precipitates into GALLSTONES

Release of Cholecystokinin

Gallbladder contracts

Billiary obstruction occurs. It can obstruct the narrow

terminal ileum , causing gallstone ileus. inflammation

Absorption of bilirubin Stasis of bile

into blood

Irritation &
Jaundice inflammation of
bile duct

Cholangitis