Increasing the intracellular levels of such polyamines can reverse aging related processes, leading

ultimately to increased lifespans in a great variety of life forms such as yeast, flies and human
immune cells.

approach, an inverse strategy to classic ionotropic nanoparticle preparation has been proposed
based on negatively charged ionic cross linkers such as tripolyphosphate or sodium sulfate. The main
interests in such a strategy are related to the possibility to: develop nanoparticles based on anionic
endogenous polymers such as hyaluronic or chondroitin without the necessity of modify them or
use chemicals that can alter their high biological value ( endogenous polymers in puris naturabilis);
benefit from the specific properties of these biogenic polyamines, which are essential for tissue
growth processes and cell differentiation and have specific receptors for their internalization. They
possess special properties conferring protection to DNA against oxidative. Increasing the
intracellular levels of such polyamines can reverse aging related processes, leading ultimately to
increased lifespans in a great variety of life forms such as yeast, flies and human immune cells.