the cxleplavm of human cells ond is common iy ‘ergoni Nope dele pay mantof weyers lative Phase sit hos sewcal impertont oles: ON prowdes 0 way for ov cells fo ovidine glucose 40 create NADPH. Unlike NAOH, MADPH contain a phosphorylaicd 2'-hydroryl group OM Chicos G-gheghale + 2NADP’ + Hho ane of the mbow units KADPH is usd os a ceducing agent ins J sfally acid biocyntheris coucleotiae biorynth Fubose S-phosphale + ZNADPH + 2H* + Cor ln the Fit phase the cell breaks down glucose into a ony teak down pm rugs nnd fam te dnl. file sugar, searing a corbon die ad grain te BN proudes a woy to cyntbenive pembose sugars Cue-ribose) thal ore sncorp calcd ints impeclant bierolecules such os OWA,RNA, AIP, NADH, FAD TL. Nonovidative Phase and cotneyme “A the syathesis ond breatdoun of four and seven corben sugars. Sugars SSL Other sugars = five -corban) ¥ esCracow Ephesghale #0 Ack ydiogenace " 6 phosphoglucond Slacone The ovdative phave begins with the dehydrogenation of the glucose 6 phos- pate at tne ta ‘arhon, An enyene aa gtaiose & hugh Addie catalqes the Aransfee of a hydede ion QW an NADP, foening NADPH ond reas a hyd Ths fom og ion ntearsleular ester called C phophoghcos lactone, Clason phone san 20s 3) flr We glurer andl onto 6 phephequtomake 9, mo" debrydinge nore * ct + ADE serene EOF + NADPH C0, en wero cuore 6 phsphofaconate Bibalse $-phosphate oer, an enuyene called 6 phosphe fiucsnale dehydiogen ase olalyus the Secdatiedecarbnectan of 6-phosphogluconde A Coy molecule is released, « pentose 1ugor (4 produced and onetner NADPT 15 tcduced to NADPH. 2/008 Phesphepenlere 7 werneare OOF @ é Lodenose dion Kore 8 ie at enone, elt wE-ot D-Riblore s-phosphake oro 6 phepho gona Blane a hel iA-baye cotalyred reaction that converts the ribulose (kelox)NADPH melecules ond a pentose sugar cae ribose S=phesphale. thea needed, he vbose 5 phosphate fon be used 4o creole ONA,ANA ond nucleotide: box roleales oe 0 bee 5 praphate Ths generals Wes CGAP) and beptos Csedokeptalost). the cabblyied by Yansbelclace cinch ves fay ocd hayaine | * eer ceed oir pephoy le fe 2 NADPH: ——> Chileskcol broryatheis cue Gus oiideln, Madeatide byosyetene ae Tenalhlee phesphale phase Ribose Neubortter bosqbes] @ EM oe t S-phusphate een Fa Gyadyhe 7 aaa asjwone40 koretal Inermediates Sedcheplalose - ete ee | a AS “ttn the cll aces NADPH mak mate Than riboze S-yhosphale, iW con convert the pemoxe suger inte. glycolytic inkermediates via WE nonoridalive phase. «The Hnitd step comets GAP ond setchephon into o hexose 1 fetrose (ery hvose). ths is caalyued by spho pentose em4oH Cfiuclose & phosplate| ond a fetrose Cery ly Met Sy" gr am din ey me Se onello, ado 5 pee spate Spinpae ONES Then Exes tne a Exyinrose — Xylalon Transtelolose yort-n “dsipiok > epha es wo Net Rea a? Glyceraldehyde aa aes tpcaldge Be Abe | > 7, Fes