71152018 __Amimierobal Use Guidelines for Treatment of Urinary Tract Disease in Dogs and Cals’ Antimicrobial Guidelines Working Geoup ofthe In ‘Table 2: Antimicrobial treatment options for urinary tract infections in the dog and cat. Drug Dose ‘Comments Amoxicillin 115 mg/kg PO Good first-line option for UTIs. Exereted in urine predominantly in active form if normal renal function is present. Ineffective against ash beta-lactamase-producing bacteria. Dogs: 15-30 hs Not recommended for routine use but may be useful for treatment of 24h n | Amikacin CIMISG 4% multidrug resistant organisms. Potentially nephrotoxic. Avoid in animals with renal insufficiency. mg/kg IVIIM/SC q24h 125-25 mgrkg PO qBh (dose based on combination of amoxicillin + clavulanate) Amoxicillin/clavulanate Not established whether there is any advantage over amoxicillin alone. Ampicillin 12-25 mg/kg PO Cephalexin, Cefadroxil 9135, Not recommended because of poor oral bioavailability. Amoxicillin is preferred. Enterococci are resistant. Resistance may be common in Enterobacteriaceae in some regions. 8 mg/kg single SC injection. ‘Should only be used in situations where oral treatment is problematic. Enterococci are resistant. Pharmacokinetic data are Cefovecin Can be repeated available to support the use in dogs and cats, with a duration of 14 once after 7-14 days (dogs) and 21 days (cats). The long duration of excretion in the days. urine makes it difficult to interpret posttreatment culture results, 5 to 10 mg/kg . Cefpodoxime proxetil 3944 po Enterococei are resistant. Ceftiofur 2mg/kg q12- Approved for treatment of UTIs in dogs in some regions. elon 24h SC Enterococci are resistant. ee a Reserved for multidrug resistant infections with few other options. a Pe ‘Myelosuppression can occur, particularly with long-term therapy. Chloramphenicol q8hCats: 12.5— “ 7 " ? Jomelke PO AV0id contact by humans because of rare idiosyneratie aplastic anemia. qi2h Ciprofloxacin 30 mg/kg PO Sometimes used because of lower cost than enrofloxacin. Lower and q24h more variable oral bioavailability than enrofloxacin, marbofloxacin, tps: wanda comouralsivmi2011/263768tab21 1271152018 _Amimierobal Use Guidelines for Treatment of Urinary Tract Disease in Dogs and Cals’ Antimicrobial Guidelines Working Geoup of the In and orbifloxacin, Difficult to justify over approved fluoroquinolones. Dosing recommendations are empirical. Doxycycline Enrofloxacin 3-5 mgikg PO Highly metabolized and exereted through intestinal tract, so urine qi2h levels may be low, Not recommended for routine uses. Smg/kg PO EXCteted in urine predominantly in active form, Reserve for aah (eatsy1- documented resistant UTIs but good First-line choice for Jomgke yon PYelonephritis 20:mgykg PO q24h). Limited efficacy against (aous) enterococci. Associated with risk of retinopathy in cats. Do not exceed 5 mg/kg/d of enrofloxacin in cats. Imipenem-74) therapy is anticipated, ime opeim on total baseline Schirmer’s tear testing is recommended, with periodic re- uu me trimethoprim + evaluation and owner monitoring for ocular discharge. Avoid in sulfadiazine dogs that may be sensitive to potential adverse effects such as KCS, concentration hepatopathy, hypersensitivity, and skin eruptions. tps: wanda comouralsivmi2011/263768tab21 22