Drug Study Classification Mechanism of Action Indication Contraindication Adverse Reaction Nursing Responsibilities

Generic Name: Pharmacologic Competitively inhibits the General Indications Contraindicated CNS: Headache, Before:
Ranitidine hydrochloride Class: action of histamine at the H2 - Short-term - allergy to ranitidine, malaise, dizziness, - Observe 15 rights in drug
Histamine-2 (H2) receptors of the parietal treatment of active lactation. somnolence, administration.
Trade Name: antagonist cells of the stomach, duodenal ulcer . insomnia, vertigo - Assess history: allergy to
Zantac inhibiting basal gastric acid - Maintenance Precaution CV: Tachycardia, ranitidine, impaired renal or
Therapeutic secretion and gastric acid therapy for - impaired renal or bradycardia, PVCs hepatic function, lactation,
Dosage: Adults Class: secretion that is stimulated duodenal ulcer at hepatic function (rapid pregnancy.
Active duodenal ulcer: 150 mg bid PO for 4–8 wk. Gastric acid by food, insulin, histamine, reduced dosage - pregnancy IV administration) - Assess for patient's affect
Alternatively, 300 mg PO once daily at bedtime or 50 secretion cholinergic agonists, gastrin, - Short-term Dermatologic: and orientation; liver
mg IM or IV every 6–8 hr or by intermittent IV inhibitor and pentagastrin. treatment and Drug-drug Interactions: Rash, alopecia evaluation, CBC, renal
infusion, diluted to 100 mL and infused over 15–20 maintenance - Increased effects of GI: Constipation, function test.
min. Do not exceed 400 mg/day. Pregnancy Pharmacokinetics therapy of active, warfarin, TCAs. diarrhea, nausea,
Maintenance therapy, duodenal ulcer: 150 mg PO at Category B Route Onset Peak Durati
benign gastric ulcer vomiting, During:
bedtime. on - Short-term abdominal pain, - Administer oral drug with
Maintenance therapy, gastric ulcer: 150 mg PO at Oral Varies 1-3 hr 8-12 treatment of GERD hepatitis, meals and at bedtime.
bedtime. hr - Pathologic increased ALT - Decrease doses in renal and
Active gastric ulcer: 150 mg bid PO or 50 mg IM or IV IM Rapid 15 min 8-12 hypersecretory levels liver failure.
hr
every 6–8 hr. Iv Imme 5-10 8-12 conditions (eg, GU: - Administer IM dose
Pathologic hypersecretory syndrome: diate min hr Zollinger-Ellison Gynecomastia, undiluted, deep into large
150 mg bid PO. Individualize the dose with patient’s syndrome) (adults impotence or muscle group.
response. Do not exceed 6 g/day. only) decreased
GERD, esophagitis, benign gastric ulcer: 150 mg bid Metabolism: Hepatic; - Treatment of libido After:
PO. T1/2: 2-3 hr erosive esophagitis Hematologic: - instruct patient to take drug
Treatment of heartburn, acid indigestion: 75 mg PO Distribution: Crosses - Treatment of Leukopenia, with meals at bedtime.
as needed. placenta, enters breast heartburn, acid granulocytopenia, - instruct patient of the side
milk indigestion, thrombocytopeni effects.
Availability: Excretion: Urine sour stomach a, pancytopenia - instruct to report sore
Tablets—75, 150, 300 mg; capsules—150, 300 mg Local: Pain at IM throat, fever, unusual
effervescent tablets and granules— site, local burning bruising or bleeding, tarry
25, 150 mg or stools, confusion,
syrup—15 mg/mL; itching at IV site hallucinations,
injection— 1, 25 mg/mL Other: Arthralgias dizziness, severe headache,
muscle
Routes of Administration: or joint pain.
Oral - Document that the drug
Intravenous has been given.
Intramuscular

Source: Karch, Amy:2012 Lippincott's Nursing Drug Guide, pp. Source: Karch, Source: Karch, Amy:2012 Source: Karch, Amy:2012 Source: Karch, Amy:2012 Source: Karch, Source: Karch, Amy:2012
1035-1037 Amy:2012 Lippincott's Lippincott's Nursing Drug Guide, pp. Lippincott's Nursing Drug Lippincott's Nursing Drug Amy:2012 Lippincott's Lippincott's Nursing Drug Guide, pp.
Nursing Drug Guide, 1035-1037 Guide, pp. 1035-1037 Guide, pp. 1035-1037 Nursing Drug Guide, 1035-1037
pp. 1035-1037 pp. 1035-1037