(9) United States US 2012025150241 c2) Patent Application Publication (1) Pub. No.: US 2012/0251502 AI ‘Towner et al. (43) Pub. Date: Oct. 4, 2012 (sa) sy 0) en @ (66) (@) HUMAN EBOLA VIRUS SPECIES AND COMPOSITIONS AND METHODS THEREOF Jnventors: Jonathan S. Towner, Adanto, GA (US): Stuart T Nichol, Alana, GA (US): James A. Comer, Anta, GA (US); Thomas G. Ksiazek, Aionts, GA (US): Pierre E, Rolin, “Aulanta, GA (US) Assignce: ‘The Government ofthe US as Represented by the Secretary of the Dept. of health, Atlanta, GA. (Us) Appl. No, 13/125,890 PCT Filed ‘Oct. 26,2009 PCT No. PeTAUS09/62079 $371 0X), (2),(4)Date: un, 21,2001 Related US. Application Data Division of application No. 61/108,175, fied on Oxt. 24, 2008, Publication Classi Incl. AGIK 38776 (2006.01) co7n 2104 (2006.01) Cran 704 (2006.01) Cork 1408 (2006.01) AGIK 38702 (2006.01) AGIK 31/7088 (2006.01) co7k 7706 (2006.01) Cork 78 (2006.01) cnn 700 (2006.01) core 2102 (2006.01) (2) US. 424998.6;435/235.1; $3628.72; 435/236. 530/350, 514/11: 514/44 R: $3030, 580/329; S30/328; S30/327: 530/326; 530/325: 330324 on ABSTRACT Compositions and methods including and related the Ebola Bndibugyo vinis(EboBun) are provided. Compositions are provided that are operable as immunogens to eliit and Immune response or protection from Ehottun challenge in a subject such asa primate, laventive methods are directed 9 ‘etoction and treatment of EboBun infection,Patent Application Publication Oct. 4, 2012 Sheet 1 0f27 | US 2012/0251502 Al aw Kony 187 Marburg sqrt Zimbabwe 1978 or onc 1998, *| 1379¢ Angola 2008 | Powe UgndssGermany 1967 nce) ZAlF@, Yorbuku 1976 90 Zaire, Kw 1998 sw Cote divoiress5s ‘Uganda, sinsitiays 2007 ‘Sudan cus Ugenda 2000 Ebola. as cubetane Reston usa st FedOct. 4,2012 Sheet 20f27 US 2012/0251502 A1 Patent Application Publication