a Appendix 7 inte ; Institute for Toxicological Studies Imtox@vsnlcom — wiwrintoxlab.com Aoglstratlon No 6 1999 / CPCSEA Ministry of Social Justice and Empoworment, Government of Inde REPORT j Study Title : i Primary Skin Irritation Study : of Deltamethrin Technical ; in Rabbit r “ 5 O ting Facil Sponsor INTOX PVT. LTO, Meghmani Organics Limites ‘ 375, Urawade, "Meghmani House", : Tel, Mush Shree Nivas Soclely, Pala, : Dist. Pune - 412 108, Ahmedabad - 380 007 ' Maharashtra, ‘ INDIA ‘ Study Number Report Number 5336 RISS35IPSI Date : 07 July, 2005 ) ‘Total numbor of pages in this report: 13, INTOX PVT. LTO. 375, Urawade, Pirangut Urawade Road, Tl, Mulshl, Dist. Pune 412408, INDIA, ‘ Tel, +91-20-2282 3633 TelFex +91-20-2292 3643ay ww R/S336/PS1 07 July, 2005 SUMMARY Deltamethrin Tecinical was tested for its skin irritation potential in New Zealand White rabbits as per the guidelines laid down by "Gaitonde Committee Recommendations, Central Insecticides Board, Ministry of Agriculture, Government of India’. The test article, Deltamethrin Technical, in the amount of 0.5 g was applied to intact and abraded clipped back skin sites of three rabbits per sex. The site of application was covered with gauize patch which was secured with adhesive tape. The test article was kept in contact for 24 hours followed by removal of dressing and washing the site of application. Skin reaction was evaluated at each site of application following Draize's method at 24 and 72 hours after application The results indicate that, Deltamethrin Technical did not cause skin reaction as observed at 24, and 72 hours after the patch was removed. No other signs of toxicity were seen In any of the treated animals. The Primary Skin Irritation index was zero (0.00) as determined from the scores of the skin reactions Based on the Primary Skin Irritation index, the test article, Deltamethrin Technical Is to be Classified as non-trritant to skin of the rabbit, as defined in the criteria for evaluation. (PY _GELPI KURMWALESTARI age 4 of 13