Professional Documents
Culture Documents
Failure and
Use of Mechanical Ventilation
n Alveolar–capillary
units
Respiratory System
Brain
Spinal cord
Nerves
Intercostal
muscles
Un it
l a r
Al ve o
g:
Lun
Chest wall
Airway
Pleura
Diaphragm
Epidemiology
n Acute on chronic
n E.g.: acute exacerbation of advanced COPD
Pathophysiology: Mechanisms
n Hypoxemic failure
n Ventilation/Perfusion (V/Q) mismatch
n Shunt
n Exacerbated by low mixed venous O2 (SvO2)
n Hypercapnic failure
n Decreased minute ventilation (MV) relative to
demand
n Increased dead space ventilation
Pathophysiology:
Etiologic Categories
n Nervous system n Neuromuscular
failure (Type II) transmission failure
n Central (Type II)
hypoventilation
n Myasthenia gravis
n Neuropathies
n Microbiology
n Respiratory cultures: sputum/tracheal
aspirate/broncheoalveolar lavage (BAL)
n Blood, urine and body fluid (e.g. pleural) cultures
Diagnostic Investigations
n Chest radiography
n Identify chest wall, pleural and lung parenchymal
pathology; and distinguish disorders that cause
primarily V/Q mismatch (clear lungs) vs. Shunt
(intra-pulmonary shunt; with opacities present)
n Electrocardiogram
n Identify arrhythmias, ischemia, ventricular
dysfunction
n Echocardiography
n Identify right and/or left ventricular dysfunction
Diagnostic Investigations
n Pulmonary function tests/bedside spirometry
n Identify obstruction, restriction, gas diffusion abnormalities
n May be difficult to perform if critically ill
n Bronchoscopy
n Obtain biopsies, brushings and BAL for histology, cytology
and microbiology
n Results may not be available quickly enough to avert
respiratory failure
n Bronchoscopy may not be safe in the if critically ill
Respiratory Failure:
Management
n ABC’s
n Ensure airway is adequate
n Ensure adequate supplemental oxygen and assisted
ventilation, if indicated
n Support circulation as needed
Respiratory Failure:
Management
n Treatment of a specific cause when possible
n Infection
n Antimicrobials, source control
n Airway obstruction
n Bronchodilators, glucocorticoids
n Improve cardiac function
n Positive
airway pressure, diuretics, vasodilators,
morphine, inotropy, revascularization
Respiratory Failure:
Management
n Mechanical ventilation
n Non-invasive (if patient can protect airway and is
hemodynamically stable)
n Mask: usually orofacial to start
n Invasive
n Endotrachealtube (ETT)
n Tracheostomy – if upper airway is obstructed
Respiratory Failure
Fails
Indications for Mechanical
Ventilation
n Cardiac or respiratory arrest
n Tachypnea or bradypnea with respiratory fatigue or
impending arrest
n Acute respiratory acidosis
n Refractory hypoxemia (when the PaO2 could not be
maintained above 60 mm Hg with inspired O2 fraction
(FIO2)>1.0)
n Inability to protect the airway associated with depressed levels
of consciousness
Indications for Mechanical
Ventilation
n Shock associated with excessive respiratory work
n Inability to clear secretions with impaired gas exchange
or excessive respiratory work
n Newly diagnosed neuromuscular disease with a vital
capacity <10-15 mL/kg
n Short term adjunct in management of acutely increased
intracranial pressure (ICP)
Invasive vs. Non-invasive
Ventilation
n Consider non-invasive ventilation particularly
in the following settings:
n COPD exacerbation
n Cardiogenic pulmonary edema
n Obesity hypoventilation syndrome
n Noninvasive ventilation may be tried in selected
patients with asthma or non-cardiogenic hypoxemic
respiratory failure
Goals of Mechanical
Ventilation
n Improve ventilation by augmenting respiratory
rate and tidal volume
n Assistance for neural or muscle dysfunction
n Sedated, comatose or paralyzed patient
n Neuropathy, myopathy or muscular dystrophy
n Intra-operative ventilation
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