nna a oct Intermittent prophylaxis of recurrent febrile seizures with clobazam versus diazepam. Sitar, Sone 8k, Pareen, Banus Mensa A, Anns AL, Quédus MR. Kar MM, pam SA, Hesue MA, Hoe MR, © Author information Abstract Fete seleues are the most cena ype of sez among ein hat ean be preveted by using prophylactic crags tke Clobszam and Diazepam. The present prospective study was conducted in the Departmert of Pedatris, Mymensingh Medal Colege Hospal anc Community Based Masical Colege Hosptal, agladesh over a period oft year rom July 2012 to une 2013 to compare the effeiveress of nermtent ‘lobazam versus Diazepam therapy preventing the recurrence of ferieseiawes and assessed adverse effects ofeach ug. Atotl of 85 Patient (2 chron acrnsteced Cabazam and rest 33 cildren eceved Diazepam) of snple and complex feb seizures aged 8 rarths to S ‘years ofboth sexes were the sty ppuation. Data were eolected by iteniew ofthe patents, crcl errnatin ad laboratory vestigations ting the research instrument. Data were analyze by uing Chi-square (y2) Tes, Student's Tet and Fiche Exat Test. For al anaytial tests, the level of signfeance was se at 0.08 and p=0.05 was considered signfcart. The proportion of pater was higher between age 12-38 ‘months and male was predominant the beth Clobezam and Diazepam groups, Over 31% of patie in Cabazam group wio expenenced peace of ever win 3 months, 406% wh 6 months ard 0.4% win 9 marth compared 364% in Diazepam group wth 3 morte, 45.5% wan 6 month & 12.1% witha 9 merths ater discharge fom the hosp. Tree (84%) patients in Ccbazam grou and 7(21.3%) Diazepam group wo experenced fesle comalson ding the flow up ped. From the data adverse effects within 3 end months ‘experienced bythe rations drowsiness, sedation and ataxia were higher Diazepam group than those In bazar group, However, win 8 ‘months lthargy ad itatilty wee vewhat higher in Cldbazam group than these in Diezopam group. Tho naan duration of hosptatztion vas sgn higher in Dazepam soup compered to Clobazam group (8 Os1,0 vs 4,640.08 cays, P0.001) Seven (21.2%) ou of 3 chien wah ebrie seizures n Dazecam grup hada story of recuret sezues, whereas (9.4%) of 32 ern nthe Cobazam grup. The sks of reuren febrile seizure inthe Diazepam group was 2.8 times greater compared to tho inte Clabazam grup (P-.186). The reeut Inictes that Clobazam i safe, effcaceus, equres les frequent dosing and has less adverse effects such as drowsiness sedation, ataia and tary as compared to Diazepam So, Ciobazam may be an akerate to Dlazepam given htermttert or prevertin of recut febrile