𝑆. 𝐹.

𝑑𝑜𝑠𝑖𝑠 −𝐾𝑡
𝐶1 = (𝑒 1 )
𝑉
1 × 1 × 140 𝑚𝑔 −(0,346)×(1)
𝐶1 = (𝑒 )
0,25 𝐿/𝑘𝑔 × 70

= 8 × 0,71

= 5,7𝑚𝑔/𝐿

𝐶𝑙
𝐾=
𝑉
6,06𝐿/𝑗𝑎𝑚
𝐾=
17,5𝐿

= 0,346 𝑗𝑎𝑚−1

(140 − 𝑢𝑠𝑖𝑎) × (𝐵𝐵) 60 𝑚𝑒𝑛𝑖𝑡/𝑗𝑎𝑚

𝐶𝑙𝐶𝑟 𝑤𝑎𝑛𝑖𝑡𝑎 = 0,85 ×( )
(72) × (𝑆𝑟𝐶𝑟) 1000𝑚𝐿/𝐿

(140 − 30) × (70) 60 𝑚𝑒𝑛𝑖𝑡/𝑗𝑎𝑚

𝐶𝑙𝐶𝑟 = 0,85 ×( )
(72) × (0,9) 1000𝑚𝐿/𝐿

= 6,06 𝐿/𝑗𝑎𝑚

0,693
𝑡 1/2 =
𝐾

0,693
𝑡 1/2 =
0,346

= 2,0 𝑗𝑎𝑚

𝑑𝑜𝑠𝑖𝑠
𝑆×𝐹×( 𝑡 )
𝑖𝑛
𝐶2 = (1 − 𝑒 −𝐾𝑡𝑖𝑛 ) (𝑒 −𝐾𝑡2 )
𝐶𝑙
140
1×1×( 𝑗𝑎𝑚)
0,5
𝐶2 = (1 − 𝑒 −(0,346.0,5) )(𝑒 −(0,346.0,5) )
6,06

= 46, 2𝑚𝑔/𝐿 × 0,16 × 0,84

= 6,2𝑚𝑔/𝐿
 𝐶
𝐼𝑛(𝐶1 )
2
𝐾=
𝑡
8
𝐼𝑛 (3)
𝐾=
7
0,98
𝐾=
7

𝐾 = 0,14 𝑗𝑎𝑚−1

𝑆 × 𝐹 × 𝑑𝑜𝑠𝑖𝑠 𝑆 × 𝐹 × 𝑑𝑜𝑠𝑖𝑠
𝐶𝑠𝑠 = 𝑉 𝑒 −𝐾𝑡1
→𝑉= 𝐶𝑠𝑠 𝑒 −𝐾𝑡1
1 − 𝑒 −𝐾𝜏 1 − 𝑒 −𝐾𝜏
1 × 1 × 100
8𝑚𝑔/𝐿
𝑉= 𝑒 −(0,14×1)
1 − 𝑒 −(0,14×8)
12,5
𝑉= 0,87
0,67

𝑉 = 16,2𝐿

𝐶𝑙 = 𝐾. 𝑉

𝐶𝑙 = 0,14 𝑗𝑎𝑚−1 × 16, 2𝐿

𝐶𝑙 = 2,3𝐿. 𝑗𝑎𝑚−1

Teofilin

𝑉 𝑎𝑚𝑖𝑛𝑜𝑓𝑖𝑙𝑖𝑛 = 0,5𝐿/𝑘𝑔 × 𝐵𝐵

𝑉 𝑎𝑚𝑖𝑛𝑜𝑓𝑖𝑙𝑖𝑛 = 0,5 𝐿/𝑘𝑔 × 80𝑘𝑔

𝑉 𝑎𝑚𝑖𝑛𝑜𝑓𝑖𝑙𝑖𝑛 = 40 𝐿

𝑉×𝐶
𝑑𝑜𝑠𝑖𝑠 𝑚𝑢𝑎𝑡𝑎𝑛 =
𝑆×𝐹
 40 × 15𝑚𝑔/𝐿
𝑑𝑜𝑠𝑖𝑠 𝑚𝑢𝑎𝑡𝑎𝑛 =
0,8 × 1

𝑑𝑜𝑠𝑖𝑠 𝑚𝑢𝑎𝑡𝑎𝑛 = 750 𝑚𝑔

𝐶𝑙 × 𝐶𝑠𝑠𝑎𝑣𝑒 × 𝜏
𝑑𝑜𝑠𝑖𝑠 𝑝𝑒𝑚𝑒𝑙𝑖ℎ𝑎𝑟𝑎𝑎𝑛 =
𝑆×𝐹

(0,04𝐿/𝑘𝑔/𝑗𝑎𝑚 × 80𝑘𝑔) × 15𝑚𝑔/𝐿 × 1 𝑗𝑎𝑚

𝑑𝑜𝑠𝑖𝑠 𝑝𝑒𝑚𝑒𝑙𝑖ℎ𝑎𝑟𝑎𝑎𝑛 =
0,8 × 1

48
𝑑𝑜𝑠𝑖𝑠 𝑝𝑒𝑚𝑒𝑙𝑖ℎ𝑎𝑟𝑎𝑎𝑛 =
0,8

𝑑𝑜𝑠𝑖𝑠 𝑝𝑒𝑚𝑒𝑙𝑖ℎ𝑎𝑟𝑎𝑎𝑛 = 60 𝑚𝑔 𝑎𝑚𝑖𝑛𝑜𝑓𝑖𝑙𝑖𝑛 𝑎𝑛ℎ𝑖𝑑𝑟𝑎𝑡 /𝑗𝑎𝑚

𝐶𝑙 𝑎𝑚𝑖𝑛𝑜𝑓𝑖𝑙𝑖𝑛 = (𝐶𝑙 × 𝐵𝐵) × (𝑓𝑎𝑘𝑡𝑜𝑟 𝑝𝑒𝑟𝑜𝑘𝑜𝑘 × 𝑓𝑎𝑘𝑡𝑜𝑟 𝐶𝐻𝐹 × 𝑓𝑎𝑘𝑡𝑜𝑟 𝑃𝑃𝑂𝐾)

𝐶𝑙 𝑎𝑚𝑖𝑛𝑜𝑓𝑖𝑙𝑖𝑛 = (0,04𝐿/𝑘𝑔/𝑗𝑎𝑚 × 80 𝑘𝑔) × (1,6 × 0,5 × 0,8)

𝐶𝑙 𝑎𝑚𝑖𝑛𝑜𝑓𝑖𝑙𝑖𝑛 = (3,2𝐿/𝑗𝑎𝑚) × (0,64)

𝐶𝑙 𝑎𝑚𝑖𝑛𝑜𝑓𝑖𝑙𝑖𝑛 = 2,048 𝐿/𝑗𝑎𝑚

𝐶𝑙 × 𝐶𝑠𝑠𝑎𝑣𝑒 × 𝜏
𝑑𝑜𝑠𝑖𝑠 𝑝𝑒𝑚𝑒𝑙𝑖ℎ𝑎𝑟𝑎𝑎𝑛 =
𝑆×𝐹

2,048 𝐿/𝑗𝑎𝑚 × 15𝑚𝑔/𝐿 × 1 𝑗𝑎𝑚

𝑑𝑜𝑠𝑖𝑠 𝑝𝑒𝑚𝑒𝑙𝑖ℎ𝑎𝑟𝑎𝑎𝑛 =
0,8 × 1

30,72
𝑑𝑜𝑠𝑖𝑠 𝑝𝑒𝑚𝑒𝑙𝑖ℎ𝑎𝑟𝑎𝑎𝑛 =
0,8

𝑑𝑜𝑠𝑖𝑠 𝑝𝑒𝑚𝑒𝑙𝑖ℎ𝑎𝑟𝑎𝑎𝑛 = 38,4 𝑚𝑔 𝑎𝑚𝑖𝑛𝑜𝑓𝑖𝑙𝑖𝑛 𝑎𝑛ℎ𝑖𝑑𝑟𝑎𝑡/𝑗𝑎𝑚

0,693 × 𝑉
𝑡1/2 =
𝐶𝑙
0,693 × (0,05𝐿/𝑘𝑔 × 80𝑘𝑔)
𝑡1/2 =
2,048𝐿/𝑗𝑎𝑚

0,693 × (40𝐿)
𝑡1/2 =
2,048𝐿/𝑗𝑎𝑚

𝑡1/2 = 13,535 𝑗𝑎𝑚~14 𝑗𝑎𝑚

 𝐶
𝐼𝑛(𝐶1 )
2
𝐾=
𝑡
32
𝐼𝑛 (16)
𝐾=
12 𝑗𝑎𝑚
0,693
𝐾=
12

𝐾 = 0,058 𝑗𝑎𝑚−1

𝐶𝑙 = 𝐾 × 𝑉

𝐶𝑙 = 0,058 𝑗𝑎𝑚−1 × (0,5𝐿/𝑘𝑔 × 72𝑘𝑔)

𝐶𝑙 = 2,08 𝐿/𝑗𝑎𝑚~2,1𝐿/𝑗𝑎𝑚

𝐶𝑙 × 𝐶𝑠𝑠𝑎𝑣𝑒 × 𝜏
𝑑𝑜𝑠𝑖𝑠 𝑝𝑒𝑚𝑒𝑙𝑖ℎ𝑎𝑟𝑎𝑎𝑛 =
𝑆×𝐹

2,1 𝐿/𝑗𝑎𝑚 × 15𝑚𝑔/𝐿 × 1 𝑗𝑎𝑚

𝑑𝑜𝑠𝑖𝑠 𝑝𝑒𝑚𝑒𝑙𝑖ℎ𝑎𝑟𝑎𝑎𝑛 =
0,8 × 1

31,5
𝑑𝑜𝑠𝑖𝑠 𝑝𝑒𝑚𝑒𝑙𝑖ℎ𝑎𝑟𝑎𝑎𝑛 =
0,8

𝑑𝑜𝑠𝑖𝑠 𝑝𝑒𝑚𝑒𝑙𝑖ℎ𝑎𝑟𝑎𝑎𝑛 = 39,38 𝑚𝑔 𝑎𝑚𝑖𝑛𝑜𝑓𝑖𝑙𝑖𝑛 𝑎𝑛ℎ𝑖𝑑𝑟𝑎𝑡/𝑗𝑎𝑚