CD2 and CD3 are major markers retained on all peripheral T cells and are useful for identifying

and
counting these cells. (BRS)

CD4+ T cells help B cells make antibodies and produce cytokines to recruit phagocytes and activate other
leukocytes. (FA)
CD8+ T cells directly kill virus-infected cells. (FA)

Positive selection of T cells occurs in the thymic cortex where T cells expressing TCRs capable of binding
self-MHC on cortical epithelial cells survive. (FA)

Negative selection of T cells occurs in the thymic medulla where T cells expressing TCRs with high affinity
for self-antigens undergo apoptosis. (FA)

During the T cell negative selection process, tissue-restricted self-antigens are expressed in the thymus
due to the action of autoimmune regulator (AIRE), and deficiency leads to autoimmune polyendocrine
syndrome-1.

Naïve helper T cells possess TCR as well as CD3 and CD4 proteins on their cell surface.