1.

Normal and Arthritic Joints 7

2. Pathophysiology of Rheumatoid Arthritis 11

3. Alangium salviifolium plant 30

4. Barks of Alangium salviifolium 30

5. Leaves and fruits of Alangium salviifolium 30

6. Active constituents present in Alangium salviifolium 33

 ABREVIATIONS
WHO World Health Organization

NOS Nitric Oxide Synthase

cNOS Constitutive NOS

iNOS Inducible NOS

LOXs Lipoxygenases

HPETEs Hydroperoxyeicosatetraenoic Acids

PUFAs Poly-unsaturated Fatty Acids

IFN-𝜸 interferon-γ

TNF-𝜶 Tumor Necrosis Factor-α

MMPs Matrix Metalloproteinase

RA Rheumatoid Arthritis

CVD Cardiovascular Disease

MTX Methotrexate

COX Cyclooxygenase

STZ Streptozotocin

DPPH 2,2-diphenyl-1- picryl-hydrazil

ANOVA Analysis Of Variance

EDTA Etheline Diamine Tetra Acitic Acid

GAE Gallic Acid Equivalent

NSAID Non-Steroidal Anti-Inflammatory Drugs

PG Prostaglandin

PLA2 Phospholipase A-2