influencing the disability in patients with knee osteoarthritis is paramount for rehabilitation. Objectives: To determine the factors that contributes to the symptoms of knee osteoarthritis. Methods: Knee Injury and Osteoarth Score questionnaire (KOOS) was used to assess the physical disability. one hundred and twenty four patients (age range 50–65 years) were randomized to therapeutic exercise (n =62) and conventional group(n = 62). Results: The results of regression analysis revealed that age and BMI factors play a role in knee osteoarthritis. Conclusion: The present study highlights the various factors that influence physical disability and thereby demonstrates to clinical researchers and practitioners that understanding and improving the quality of patient’s well-being goes beyond simply treating the underlying clinical condition.