STRING v9.

1: Edges and Nodes Provide Global Functional Association to
Protein Crosstalk and Integration in Urinary Proteomes of Prostate Cancer 

Name: Leonora V. Autus-Geniston, PhD

United Bayanihan Foundation and St. Paul University-Quezon City, 1111, Philippines

Prostate cancer was the number one cause of cancer in men in Asia. Urine like blood has a
similar source of proteins making it an ideal matrix for the study. The research aims to identify
proteins in the urinary proteomes of normal controls, benign prostate hyperplasia (BPH) and
prostate cancer by initial separation using SDS-PAGE followed by nanoLC-Orbitrap MS/MS aided
by ProteinProspector and XCalibur. STRING v9.1 predicted their functional protein association
networks among the gene lists. Three hub proteins (B2M, GSN, IGHG1) and FN1were seen in
normal state and BPH, respectively. Six functional modules in normal controls and BPH were seen,
and 12 in prostate cancer. Five and 15 unique proteins were seen in normal and BPH. HBA1, HBB
and TTR were the distinct proteins observed in prostate cancer. A unique BPH module emerged
from the normal state when their networks were overlapped. The modules at the center of the
prostate cancer networks were tight and multiply connected with loosely-arranged periphery. The
protein markers of prostate cancer, HBA1-HBB edge in module 1 in the periphery, while TTR in
module 6 at the center was connected by haptoglobin (HP) from module 5. Prostate
carcinopathogenesis from the normal state involved three protein switches: GSN-FN1, B2M-
IGHG1 and CTSB-CSTB edges independent from BPH pathogenesis. From these switches, the
expression of the known cancer functional modules emerged that linked further to HBA1-HBB-
TTR hub. The details of these events will be discussed. Thus, the present study provides a solid
framework for further understanding of prostate pathocarcinogenesis.

Biography

Dr. Autus-Geniston has completed his PhD from University of Santo Tomas. She is the Officer of
United Bayanihan Foundation and an Assistant Professor at Saint Paul University–Quezon City,
Philippines. He has published several papers in reputed journals on proteomics and
pharmacogenomics, specifically on SNPs on drug metabolizing enzymes among Filipinos. She
received the Best Poster Award in Health Science from National Academy Science and Technology
(Philippines) on Method Development of nanoLC-MS/MS for Identification of Protein Biomarkers
in the Urinary Proteomes of Prostate Cancer and Best Poster in Penang, Malaysia on Protective
Effects of Thiamin on Genotoxicity in Mice.

Presenting author details

Full name: Leonora V. Autus-Geniston, PhD
Contact number: +639175216077
Session name/ number:
Category: Oral presentation
 13 Jul (4 days
proteomicscongress ago)

to me

Dear Dr. Leonora V. Autus-Geniston,

Greetings!!

We are pleased to announce that your abstract has been accepted for Oral presentation in the conference.

We would further request you to kindly submit your Organization/University logo to update your talk in the
scientific program soon.

Also, we wish to continue your support and would be glad to have your valuable association at 9 th International
Conference and Expo on Proteomics. We kindly solicit you to visualize the registration proceedings to confirm
your participation towards the event.

Please find the link: http://www.proteomicsconference.com/registration.php where you get the details of
registration towards the event.

Note: Kindly contact me if you have any concerns regarding the registration process and fee.

Shall anticipate for your response.

Dear Dr. Leonora,

Thank you for receiving our phone calls today.

As per the telephonic conversation we would like to inform you that even though our early bird date ends today
we shall offer you with the same price till July 21, 2017.

And as you are interested to take 4 nights of accommodation you can register for Package B ($1399) on the
conference website which includes registration fee, breakfast, refreshments, lunch and 4 nights of accommodation
at the conference venue.

If you can confirm your participation by registering for the conference on/before July 21, 2017 you can avail 1
nite of complimentary accommodation from our end.

Hope you will be clear with the above provided details.

If you need any assistance please feel free to contact us.

Looking forward to hearing from you soon.

Have a great weekend...

Sincerely,
Sheeba Kosari