Mikroenkapsulasi

Septiawan Adi Nugroho

Fakultas Farmasi
Institut Ilmu Kesehatan Bhakti Wiyata
 Defenisi
• Micro-encapsulation is a process in which tiny particles or droplets
are surrounded by a coating to give small capsules.

• Mikroenkapsulasi adalah proses dimana partikel individu atau droplet

bahan padat atau cair (inti) dikelilingi atau dilapisi dengan lapisan film
dari bahan polimer (shell) untuk menghasilkan kapsul berukuran
mikrometer, yang dikenal sebagai mikrokapsul
• Bahan di dalam kapsul mikro ini terdiri dari inti, fase internal, atau isi,
sedangkan dinding disebut shell, lapisan, atau membran.
• Most microcapsules have diameters between a few micrometers and
a few millimeters.
Core Material
• Bisa cair atau padat
• inti yg berupa liqiud dapat dilarutkan atau didespersikan

• Komposisi bahan pelapis (shell):

Obat atau konstituen aktif
bahan tambahan seperti pengencer
stabilisator
Bahan peningkat laju pelepasan (enhancer)
Coating Material:
• Compatible with the core material
• Stabilization of core material.
• Inert toward active ingredients.
• Controlled release under specific conditions.
• The coating can be flexible, brittle, hard, thin etc.
• Abundantly and cheaply available

Composition of coating
• Inert polymer
• Plasticizer
• Colouring agent
E.g. Coating materials:

• Gums: Gum arabic, sodium alginate, carragenan

• Carbohydrates: Starch, dextran, sucrose
• Celluloses: Carboxymethylcellulose, methycellulose.
• Lipids: Bees wax, stearic acid,phospholipids.
• Proteins: Gelatin, albumin.
MORPHOLOGY OF MICROCAPSULES:
1- Mononuclear (core-shell) microcapsules contain the shell around the
core.

2- Polynuclear capsules have many cores enclosed within the shell.

3- Matrix encapsulation in which the core material is distributed

homogeneously into theshell material.
Tujuan
PAN COATING
SPRAY DRYING