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Secukinumab 150MG
Secukinumab 150MG
INDICATION
Plaque Psoriasis:
Starting dose: given 300 mg SC at weeks 0, 1, 2, 3, and 4
initially at week 8, administer 300 mg SC once monthly
For some patientsmay be acceptable containing dose of 150 mg
Psoriatic Arthritis : Indicated for adults with active psoriatic arthritis
Recommended dosage
Psoriatic arthritis for other patients, administer with or without a loading dosage by
SC injection
Scapho with loading dose administrated 150 mg SC at weeks 0, 1, 2, 3, and 4 and
q4wk thereafter
Scapho without loading dose administrated 150 mg SC q4wk.
Consider a dosage of 300 mg, if a patient continues to have active psoriatic arthritis
May be administered with or without methotrexate.
Ankylosing Spondylitis:
Given with or without a loading dosage by SC injection
Scapho with loading dose is administrated 150 mg SC at weeks 0, 1, 2, 3, and 4 and
q4wk thereafter
Scapho without a loading dose is administrated150 mg SC q4wk
MECHANISM
Maximum plasma concentration for single dose is 6 days and weekly dosing for first
month is 31-34 days
Volume of distribution is 7.1 – 8.6 (IV administration)
The drug scapho is Metabolized via intracellular catabolism.
Scapho has half-life is 22-31 days
PRECAUTION
Scapho may have high risk of infections; use with caution in patients with chronic
infection or a history of recurrent infection
Before to initiation of scapho,start with anti-TB therapy in patients with a history of
latent or active TB in whom an adequate course of treatment cannot be confirmed
May infuriate Crohn disease
Anaphylaxis and cases of urticaria resulted; if this appears, discontinue scapho
immediately and start anaphylaxis treatment
DRUG INTERACTION
In case of missed dose, patients must consult with medical practitioner and follow the
instructions given by them.
thereby missed dose should be avoid and follow the regular dosing schedule.
SIDE EFFECTS
• Infections
• Nasopharyngitis
• Diarrhea
• URT infection
• Rhinitis
• Oral herpes
• Pharyngitis
• Urticaria
• Rhinorrhoea