Spirocyclic compounds

R 0015 DOI: 10.1002/chin.201624112

Organohalogenite-Catalyzed Spiroketalization: Enantioselective Synthesis of
24- 112 Bisbenzannulated Spiroketal Cores. — A new core structure-motivated strategy
for the intramolecular aromatic spiroketalization process is used for the enantioselec-
tive synthesis of bisbenzannulated spiroketals, the bioactive core of rubromycins,
with high enantioselectivities (up to 98% e.e.) via an organohalogenite-mediated
asymmetric intramolecular aromatic spiroketalization. — (XUE*, J.; ZHANG, H.;
TIAN, T.; YIN, K.; LIU, D.; JIANG, X.; LI, Y.; JIN, X.; YAO, X.;
Adv. Synth. Catal. 358 (2016) 3, 370-374, http://dx.doi.org/10.1002/adsc.201500390 ;
State Key Lab. Appl. Org. Chem., Coll. Chem. Chem. Eng., Lanzhou Univ., Lanzhou,
Gansu 730000, Peop. Rep. China; Eng.) — T. Stabingis

ChemInform 2016, 47, issue 24 © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim