§ Control of Body Temperature

§ Kinds of Signals
§ Hypothalamic thermoregulatory center
§ Normal: 36.5-37.5 0C

§ Variations in Oral Temperature

§ 36.8 ± 0.4 0C

§ Circadian Rhythm
§ childhood VS elderly
§ Menstruation
§ Elevation of body temperature exceeding normal daily
variation with increase in hypothalamic set point
§ Heat conservation and Heat production
§ Thermostat Setting
§ Hyperprexia
§ fever greater than >41.5 0C
§ Severe infection and CNS hemorrhage

§ Hypothalamic fever
§ Uncontrolled increase in body temperatures that exceeds the body’s
ability to lose heat.

Fever Hyperthermia (Heat Stroke)

HTRC changed HTRC unchanged
Involves pyrogenic molecules Does not involve pyrogenic molecules
Heat conservation and heat production Exogenous heat exposure
Endogenous heat production

Slow in onset (except Systemic Sepsis) Can be rapidly fatal

Responds to antipyretics Does not respond to antipyretics
Cold skin hot and dry skin