Systhemic Lupus Erythematosus is a disease of the immune system, or an autoimmune disease, meaning

that the lupus patient's body forms antibodies that are misdirected. Antibodies that should be intended
to fight bacteria or viruses that enter the body actually damage the body's own organs, such as kidneys,
liver, joints, red blood cells, leukocytes, or platelets. Systemic lupus erythematosus is a chronic
autoimmune inflammatory disease of unknown etiology and has very diverse clinical manifestations and
prognoses. The LES incidence in the United States is 5.1 per 100,000 population, while the prevalence of
LES in the United States is reported to be 52 cases per 100,000 population with women and men
between 9-14: 1. The incidence of LES in men is very rare and the symptoms are usually not typical
compared to women. 2 Systemic Lupus Erythematosus (SLE) is a chronic multisystem autoimmune
disorder characterized by autoantibodies and immune complexes related to clinical manifestations and
extensive and extensive tissue damage. Some defects of the multiple immunologic component play an
important role in the pathogenesis of SLE. Immunologic abnormalities in SLE include the ability to
produce pathogenic autoantibodies, loss of regulation of B and T lymphocyte cells, and defective
clearance of autoantigens and immune complexes. Genetic, immunological and hormonal factors and
the environment are thought to play a role in the pathophysiology of SLE.3

SLE is still classified as a common disease in Indonesia. Many factors influence the occurrence of SLE
cases in Indonesia, including the unmet needs of patients and their families regarding information,
education, and support related to SLE. This is needed so that patients are easy in handling related
diseases. Articles were collected through the electronic database of CINAHL, ScienceDirect, and Proquest
using the keywords self-management, systemic lupus erythemathosus, fatigue, and depression. Inclusion
criteria are studies of journals published in the period between 2008-2017. Efforts to reduce the
negative effects of chronic diseases is absolutely necessary. One of them is the application of self-
management programs in SLE patients. It has been proven that the application of self-management has
an effect on reducing fatigue and depression, and improving coping skills and self-efficacy. Knowledge
and understanding of nursing programs that are relevant in the management of chronic diseases must be
developed within the scope of practice and research. Therefore, the active participation of patients and
families is an important component in the success of treatment programs4 Systemic Lupus
Erythematosus (SLE) is an autoimmune inflammatory disease with diverse clinical manifestations, course
of disease, and prognosis. Clinically, SLE is a recurring disease, and it is difficult to predict the initial
manifestations of acute and subtle, can attack various organs of the body. This disease can attack the
skin, kidneys, serous membranes, joints, and heart. Immunologically, this disease involves a confusing
arrangement of autoantibodies