Drug Study

NCM Area: Year & Section: Date Submitted:

Prepared by:

Patient Data: Name:Wylie Morgan Age/Gender: 68/Male Allergies: Penicillin

Medical Diagnosis:Acute exacerbation of congestive cardiac failure Diet: Low Salt, Low fat diet, on 1.5L fluid restriction Types of Reaction: Rashes, hives

Remarks:

Drug Name: Indication Contraindicated to people Nrsg Resp: Client educ:

with:
Generic Name: sacubitril and To decrease the risk of -Assess BP (lying, sitting, -Instruct patient to take
valsartan cardiovascular death and -Hypersensitivity to any standing) and pulse frequently Entrestoas directed, at the
hospitalization for chronic component during initial dose adjustment same time each day, even if
Trade Name:Entresto
heart failure patients (NYHA and periodically throughout feeling well.Take missed doses
-History of angioedema related
Dose: KUNG ILANG mg/ml Class II-IV and ↓ ejection therapy. Correct volume or salt as soon as remembered if not
to previous ACE inhibitor or
fraction). depletion prior to almost time for next dose; do
Frequency: ILANG BESES SA ARB therapy
administration of therapy. If not double doses.
ISANG ARAW TINETAKE
-Coadministration of hypotension occurs, consider
ANG GAMOT -Warn patient not to
MOA neprilysin inhibitors with ACE reducing dose of diuretics,
discontinue therapy unless
Route:Oral route (Tablet) inhibitors may increase concomitant antihypertensive
Combination is an angiotensin directed by health care
angioedema risk agents, and treatment of other
Date Ordered: DATE NG receptor-neprilysin inhibitor professional. Advise patient to
causes of hypotension
RESETA (ARNi) -Concomitant use with read Patient Information
(hypovolemia). If hypotension
aliskiren in patients with before starting therapy and
Pregnancy Risk Category: persist, reduce the dose or
diabetes with each Rx refill in case of
Category X temporarily discontinue
Sacubitril: Neprilysin inhibitor; changes.
therapy. Permanent
Note: neprilysin is responsible for
discontinuation of therapy is -Caution patient to avoid
degradation of atrial and brain Side Effects:
usually not required salt substitutes containing
natriuretic peptide; the
Abdominal or stomach pain potassium or foods containing
cardiovascular and renal -Monitor daily weight and
high levels of potassium or
effects of sacubitril’s active blurred vision assess patient routinely for
sodium unless directed by
metabolite (LBQ657) in heart resolution of fluid overload
confusion health care professional. See
failure are attributed to the (peripheral edema,
food sources for specific
increased levels of peptides difficult breathing rales/crackles, dyspnea, weight nutrients.
that are degraded by gain, jugular venous
Dizziness -Instruct patient to notify
neprilysin (eg, natriuretic distention).
health care professional if
peptide); administration irregular heartbeat
-Monitor frequency of swelling of face, eyes, lips, or
results in increased natriuresis,
nausea or vomiting prescription refills to tongue or if difficulty
increased urine cGMP, and
determine compliance. swallowing or breathing occur.
decreased plasma MR-proANP nervousness
and NT-proBNP -Assess patients for signs of -May cause dizziness.
numbness or tingling in the
angioedema (dyspnea, Caution patient to avoid
hands, feet, or lips
orofacial swelling); may occur driving or other activities
Valsartan: Angiotensin II sweating more frequently in Black requiring alertness until
receptor type I inhibitor; patients. If signs occur, response to medication is
unusual tiredness or
decreases blood pressure and discontinue therapy, provide known.
weakness
blocks vasoconstrictor and supportive therapy, and
-Instruct patient to notify
aldosterone-secreting effects of weakness or heaviness of the monitor for airway
health care professional of
angiotensin II legs compromise.
medication regimen before
treatment or surgery.

-Advise women of
childbearing age to use
contraception and notify
Onset: health care professional if
pregnancy is planned or
Peak:
suspected, or if breast feeding.
Duration: Entresto should be
discontinued as soon as
possible when pregnancy is
detected.

-Emphasize the importance

of follow-up exams to evaluate
effectiveness of medication.