t (jam) C (mcg/ml) AUC

0.5 19.3 9.2175 KOM

1 17.57 13.072 100
1.8 15.11 27.61
4 9.99 15.408
5.8 7.13 13.024 10

Axis Title
8 4.71 13.86
12 2.22 8.817
18 0.719 2.847 1
24 0.23 1.2777777778
AUC TotaL 105.1332777778
0.1
0 5 10 1
Axis
Perhitungan parameter farmakokinetika
Ke 0.18 jam-1
T 1/2 3.85 jam
Cp0 21.472 mcg/ml FASE
Cl 14.267604242 ml/jam 2.5
AUC 105.1332778 mcg.jam/ml
2 f(x) = 21.4720878131
Vd 79.2644680112 ml R² = 0.9999900595

1.5

Axis Title
1

0.5

0
10 12 14 16 18 20 22
Axis Title

Jawaban soal modul

1 Kompartemen 1 terbuka
2 y = 21.472e-0.189x
3 Ke 0.18 jam-1
T 1/2 3.85 jam
Cp0 21.472 mcg/ml
Cl 14.26760424 ml/jam
AUC 105.1332778 mcg.jam/ml
Vd 79.26446801 ml
 KOMPARTEMEN I
100

10
Axis Title

Col umn B

0.1
0 5 10 15 20 25 30
Axis Title

FASE ELIMINASI
2.5

2 f(x) = 21.4720878131 exp( - 0.1889319305 x )

R² = 0.9999900595

1.5
Axis Title

Col umn B
Exponential (Col umn B)
1

0.5

0
10 12 14 16 18 20 22 24 26
Axis Title
t (jam) Cp (mg/ml Cp Terminal Cp Residual AUC
0 54.05 8.993 45.057 2.1265
0.05 31.01 8.6967248167 22.3132751833 1.262
0.1 19.47 8.4102104456 11.0597895544 0.827
0.15 13.61 8.1331353159 5.4768646841 0.605
0.2 10.59 7.865188451 0.48875
0.25 8.96 7.6060691193 0.42475
0.3 8.03 7.355486497 0.387
0.35 7.45 7.1131593414 0.36225
0.4 7.04 6.8788156755 0.34425
0.45 6.73 6.6521924824 0.33
0.5 6.47 6.4330354106 0.3175
0.55 6.23 6.2210984879 0.306
0.6 6.01 6.016143846 0.2955
0.65 5.81 5.8179414529 0.2855
0.7 5.61 5.6262688553 0.27575
0.75 5.42 5.4409109285 0.2665
0.8 5.24 5.2616596349 0.2575
0.85 5.06 5.0883137912 0.24875
0.9 4.89 0.2405
0.95 4.73 0.2325
1 4.57 6.750369
AUC TOTAL 16.63387

Perhitungan Parameter Farmakokinetika

Ke 0.677 jam-1
T 1/2 1.023633678 jam
Cp0 54.0464 mcg/L
Cl 3.9076897215 L/jam
AUC 16.63387 mcg.jam/L
Vd 5.7720675355 L

Jawaban soal dimodul

 kompartemen 2
100

Axis Title
10 Col umn B

1
0 0.2 0.4 0.6 0.8 1 1.2
Axis Title

Fase Eliminasi
5
4.9
f(x) = 8.99343626 exp( - 0.6767909858 x )
4.8 R² = 0.9999046193
Axis Title

Col umn B
4.7 Exponential (Col umn
4.6 B)
4.5
4.4
0.85 0.9 0.95 1 1.05
Axis Title

Fase Distribusi
50
45
40 f(x) = 45.0533618357 exp( - 14.0481049992 x )
35 R² = 0.9999999343
30
Axis Title

Col umn D
25 Exponential (Col umn
20 D)
15
10
5
0
0 0.05 0.1 0.15 0.2
Axis Title
 Ke T 1/2 Cp0 Cl

ANTIBIOTIK 0.18/jam-1 3.85/jam 21.472 mcg/ml 14.26760424 ml/jam

ANTINYERI 0.677/jam-1 1 jam 54.0464 L/jam 3.907689722 L/jam
 AUC Vd Dosis

105.1332778 mcg.jam/ml 79.26446801 ml 1500 mg

16.63387 mcg.jam/ml 5.772067535 L 65 mg