The molecule I modified is Atropine, which is an anticholinergic drug with CNS side effects.

I changed the -OH group in the tropic acid to -CH2-CH2-NH2 side chain with paying attention to the SAR,
and here is the explanation:

-NH2 with pka near 10 is most likely to be in the ionized form (NH3+) and this would prevent the passive
diffusion across the blood brain barrier (BBB) and so on decrease the CNS side effects.

-CH2-CH2- to increase the distance between the added amino group and the preexisting carbonyl and
phenyl functionalities which will decrease their electron withdrawal effect on the added amino group.

Ahmad Yaser Yosef 0151176

Sun Tue Thu 11-12

* attached are two files made with chemdraw program one for the atropine structure and the second is
for the modified structure.