A platelet function defect in preeclampsia.

- PubMed - NCBI 9/4/19, 12(51

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Obstet Gynecol. 1985 Jan;65(1):107-9.

A platelet function defect in preeclampsia.

Kelton JG, Hunter DJ, Neame PB.

Abstract
A prospective study was performed on 26 preeclamptic patients and 17 pregnant control
subjects relating the platelet count to in vivo platelet function as assessed by the bleeding time
and in vitro platelet function as assessed by collagen-stimulated thromboxane B2 biosynthesis.
The results of these tests were normal in all control subjects. Nine of the 26 preeclamptic
patients (34%) showed thrombocytopenia, and five of these patients had a prolonged bleeding
time. Four of the 16 nonthrombocytopenic patients also had a prolonged bleeding time. Eleven
patients had impaired thromboxane B2 biosynthesis, and seven of these had a prolonged
bleeding time. In all patients, the bleeding time returned to normal, and in most the platelet count
returned to normal within five days or after delivery. A significant proportion of patients with
preeclampsia develop an acquired defect of platelet function that could contribute to bleeding.

PMID: 3966011
[Indexed for MEDLINE]

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