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  • Buni-Berry (Antidesma Bunius) Extract Inhibits LDL Oxidation in BALB/c Mice Fed With A High-Fat Diet

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    This study examined the effects of buni-berry extract on LDL oxidation in mice fed a high-fat diet. Twenty male mice were divided into four groups: one treated with buni-berry extract, one with simvastatin, one control sick group on a high-fat diet, and one control normal group on a normal diet. All groups except the control normal received a high-fat diet. The buni-berry and simvastatin groups also received oral doses of 300 mg/kgBW/day of buni-berry extract or 6 mg/kgBW/day of simvastatin, respectively. After 12 weeks, oxidized LDL levels were significantly lower in the buni-berry and simvastatin groups

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    Abstract of Buni berry research

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    Page 26 P Abstrak

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    This study examined the effects of buni-berry extract on LDL oxidation in mice fed a high-fat diet. Twenty male mice were divided into four groups: one treated with buni-berry extract, one with simvastatin, one control sick group on a high-fat diet, and one control normal group on a normal diet. All groups except the control normal received a high-fat diet. The buni-berry and simvastatin groups also received oral doses of 300 mg/kgBW/day of buni-berry extract or 6 mg/kgBW/day of simvastatin, respectively. After 12 weeks, oxidized LDL levels were significantly lower in the buni-berry and simvastatin groups

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    6 views1 page

    Buni-Berry (Antidesma Bunius) Extract Inhibits LDL Oxidation in BALB/c Mice Fed With A High-Fat Diet

    Uploaded by

    SuryaniTawali
    This study examined the effects of buni-berry extract on LDL oxidation in mice fed a high-fat diet. Twenty male mice were divided into four groups: one treated with buni-berry extract, one with simvastatin, one control sick group on a high-fat diet, and one control normal group on a normal diet. All groups except the control normal received a high-fat diet. The buni-berry and simvastatin groups also received oral doses of 300 mg/kgBW/day of buni-berry extract or 6 mg/kgBW/day of simvastatin, respectively. After 12 weeks, oxidized LDL levels were significantly lower in the buni-berry and simvastatin groups

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    of 1

    Oral Presentation

    Buni-Berry (Antidesma bunius ) Extract Inhibits LDL


    Oxidation in BALB/c Mice Fed With a High-Fat Diet
    Suryani Tawalia Suryani As'adb Mochammad Hattac Agussalim Bukharib
    a
    Department of Public Health and Preventive Medicine, Faculty of Medicine, Hasanuddin University,
    Makassar, Indonesia: bDepartment of Nutrition, Faculty of Medicine, Hasanuddin University,
    Makassar, Indonesia; c Biomolecular aand Immunology Laboratory, Departement of Microbiology,
    Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

    Keywords
    Buni-berry extract ∙ High-fat diet ∙ Cardiovascular disease ∙ Oxidized-LDL

    Background/Aims: Cardiovascular disease as the leading cause of death in the world is underlined
    by atherosclerosis caused by LDL oxidation. Consumption of high antioxidants foods is believed can
    prevent and cease this process. A local fruit that has high antioxidant content is buni-berry
    (Antidesma bunius). The aim of this study was to determine the effectivity of buni-berry extract to
    prevent oxidation of LDL in BALB/c mice fed with a high-fat diet. Methods: Twenty, thirty-weeks old
    male BALB/c mice were randomly allocated into four intervention groups; buni-berry extract,
    simvastatin, control-sick and control-normal groups. All groups received high-fat diet (HFD), except
    the control-normal group which received normal-diet. Treatments were started in all groups at the
    same time with the administration of the diets. Mice in buni-berry group were treated with oral
    buni-berry 300 mg/kgBW/day while in simvastatin group were provided with oral simvastatin 6
    mg/kkBW/day. The mice in control-sick and control-normal group were not received additional
    treatment. The intervention was con-ducted in 12 weeks. Blood samples were examined at
    baseline and after 12 weeks intervention for oxidised-LDL. Results: The increase of Oxidised-LDL
    concentration was significantly lower in the buni berry extract group (0.25 ng/mL) and simvastatin
    group (0.30 ng/mL), while in control-sick group was averagely five times higher (2.40 ng/mL), and in
    control-normal group was 0.15 ng/mL. Conclusions: Oral administration of 300 mg/kgBW/day of
    buni-berry extract for 12 weeks in HFD mice is effectively inhibits oxidation of LDL thus prevent the
    atherosclerosis process as the basis of cardiovascular diseases.

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