IRITAN MASUK

MAKROFAG EPITEL

-RELEASE INTEREUKIN 8 -FGP, TGF BETA APOPTOSIS EPHITELIUM

-LEUKOTRIN B4 -NECROSIS TUMOR

-PLATELET DERIVED

GROWTH FACTOR

CHEMOTAXIS ACTIVATED PDGF AREA GETTING DESTROYED

TISSUE FACTOR EXPOSED

RELEASE CYTOKINE + ROS

(REACTIVE OKSIGEN S ..) CLOT INFLAMATION

SAAT KE PEMBULUH DARAH

PROTEINASE / PROTEASE

TGF B

INFLAMATION

STARTING POLIFERATING
 PRODUCING ELASTIC FIBER

And COLLAGEN

AREA GETTING THICKER

EMT

(EPITHELIUM MESENCHYMA TRANSFORMATION )

EPITEL WILL BE ANCIENT CELL

MIGRATING UNDERNEATH

BECOMING SMOOTH MUSCLE

*AREA BECOMING THICKER

PREVENT/REDUCE

OKSIGEN AND KARBONOKSIDA

 OKSIGEN MENETAP,

TIDAK KE PEMBULUH DARAH

HYPOXIA

1. SECRET AND CREATE MCP (MACROPHAGE CHEMOTACTIC PROTEIN)

2. RELEASE PLASMINOGEN AKTIVATOR INHIBITION TYPE I AND II, PEMBEKUAN DAERAH TERGANGGU

BAD OUTCOMES

1. DRY HACKING COUGH

2. DYSPNEA

3. LATE RESPIRATORY CRACKLES

4. POSSIBLE COR PULMONALE

5. HONEY COMB,GROUND GLASS APPEREANCE,DIFFUSE

INFILTRATION