INTERFERENCIA DE FARMACOS SOBRE O FIGADO E PROVAS DE FUNCAO HEPATICA LLENIRA DA SILVA COSTA E MARIA DAS GRACAS ALMEIDA THORNTON. Departamento de Anlises Clinicas eToiclipcas, Centro de Clénclas da Sade da Universidade Federal de Rio A administragio de medicamentos, com finalidade te rapéutiea ou nio, pode produzir, nos seres humanos, intoxica- g8es agudas ou mesmo letais. O percentual de acidentes 17 Grande do Nore- Natal. terapéuticos poderia responder por 5 a 10% de patologias em medieina interna, Isto ocorre, devido & produgio de medica- ‘mentos cada vez mais potentes, visando a um melhor controle de doengas, mas que infelizmente tem, ao mesmo tempo, um. ‘maior potencial de induzir uma doenga iatrogénica, causada por reages medicamentosas adversas. before, v7, n° 1/4, 1999Sendo ROBINS el (1) res, camo sei ciccs cuter trata escent ‘mcs dimen crt pan © msn SE raga mcdcanetons nena Em etn dae ee oo cone eames be pam ean at ‘Scheroctitimmcligcn nn peso ago “Susan nd or el {bee qu nn parame armani Simei iyi es en se prota sie pesca a mg ‘ee game toe cette cera moms ise ‘ls etc oan 3) gue ama de Se {rs nen cen co sti ts ea «ence nl res ec ‘= nedcamens devo deen oman, fr ‘em com qo mo wwe ane Soper. A So ‘Sintra etna rams me ‘ttt pst to mame mas qlee esas reser adeno wtttins Sion sepa Ftc: davon tana e anes ‘Sim orsirhpreies emigre oe “A reneseaarc sh vive pe t ead ino pac pcg como Scan ‘ganesh, apne reel cers). ‘Ores xe Sn mc pen ig to not sca «Sgn, re #0 oe pe ar tte peoravenene Svs dt fae pra 8) 2 $e poesia. qu ote ma eel) et Fresco ions iconic mem Slo bs lo apes x congo ese tear (Shean unbenSor mcinyentn (. Scored, send tiene ep ‘a, xerem bn ai ela pve ‘os ln onuinc toges sorao team sox ctnes eran, pete po (de lap nso, se arab es ‘the dps io Tier, os eames de bai vem pn ala no Saga, opp me {Bou etnca tropes Une vor gp ees retndos ‘Shem teres eacanewnn ceo res sue ro tine pra emo ker ‘Arriola ds CARAWAY 3) vad psc de medanctn erion wn ent tne bra beaten orn cme cme ‘ad ea mame do pose. HONE cPEDHA2Z elt gem 1978 Cenarion Fer f Chal Chem mee tun see aber enc Em 198, om oem {Rodentia nak cos sie ats in: Oso, gas» meta a se meti sa opin compen os ern pes ‘camo cme sare de va ora ‘tam aegis seri dos cots lg, ‘Shmels iene deplete scan ‘Sombie ens, Ne es, on vn ug ‘Em conn pocorn sad ie inn, do mans sale bral pon sr ue cS co faa tie eh ‘Sept dx sng ego xgem care, ‘ingore areca go spas rats Ge as ‘Sema kan no ce {etre ns cumes lores po ‘ase pce le alee, Pr oto ise {Ens pre gnc ogni sere uma ena ea re foes © cso a eps wneras mex toss og ere op po debiessfars GE encom Senos erste ts roa de nj epic etd i i dc de {lr do melctment, somo so, por pb ‘eligi oe tno 21 seuboo Repiien demicos ‘Meats Metantormaode amacos € oo quis eo amas mn rams ‘mt por prctnos et A pn to ‘nels dum compo eao pi rosea ke (Orn ie tne ya. On (RR tan tpt mp pico ‘dea fg’ psn herr, Salmons ewe eye ue tales omens Tipouelivls + opoaren om fmpover mae polices © tose, con isan ago plore ‘manna dtrtearmassdeconptrcrs os 20 ofan nib ¢ extent rlatonado com Atte. Exe am mimer de sabia om gi et ron brandon ai dog soe deer ‘stems eatin de frase ¢ ttn co- mado de canis de eid de fangs ode © ‘iu umconpene ms mcssons, ol ag com 90 {fan mola yr forma niger incre {hn Ocxiil ive 6 min tt pn Hem "no-o as par or exidigoo rt. Est ssema ‘tt sade mo iter ds dla, soca a elle ‘delim predominance mar, fenaoast, incmo Create © cc PSD (10, (Octecrme MS, pl compen civic ‘emopac gu sted lata pence sor Inform v7. 1° 118, 1999[NADPI NADI rads deousenzinas sistem 86 ‘De wn forma ris dead, sedans 5 ‘remem un fl ads Se fee ou pt ii, ‘eas guna de xt, edo ou ls poe ‘ormcte nfm om sepuna fe, chads de seca 2 ‘come (Nain de cone oarmaco alia ‘u sous mealton podem se conga com substcas (igen come o fon ain, incpanet, ‘Sn sao ltt, tmando sem plas posi Sas excep (12 13, ‘0 clence Repco de Krmacs adminis, in ea, doen isa Ss enimas ge os mtb, {is cee bars, do Man anes Repco € J 0 ‘ig «eam pln ‘sgencesar ube neo que ids cerns do site ede ino tsps Se a ‘ens samen quando nina Fev aen {tain combos eric cs runt oitiion.Rearoneo polis clogs © ‘uo outs agentes ge (10 1 indo eed po orem aon omen ins tems poate redid weeks de lf me (Semen, oracle sn gi. Um xemp ese ford merc x ane oncom ose Faves ewan, mies pict age como Inder ‘ini ere oe pido wari, Nai ‘Shap inne a neo So wart ee orca du pia melas. Enel, ganas [ntrempe sdminsragh do indo, velociaae Je ‘Nesters do wasn (atcaglae oa vlna er eal done aa au’ er tle pedo povcar ‘ave moma (1) ‘Seruno FOUTS (5), xs mals e 20 substi caus ede seme microsomal epic. Ee as polem-s eit: hipatcos ¢ sedatives (babies, ‘Comaraico), fungeias(grisofltna, elon, ‘hlpdémcen afento t sarincs ier, ‘antes macue crore des splc tah enertdes(hsecorter, angen, pope, ponicemines tusmid, crt, pscxicos ‘coon, nia), wos robe at ‘ours sbstneias (Rosigre pod MEIRELLES © (ORNELLASCI2) Poretolae eeu ene lveno dint, fem que ceon medicaments, como 0 Aldo” pra inosine, slopool, cnet ene ‘un, por mccanimos giver, ie ss encias got Intl macoOeoree Gorge pad MEIRELLES CoRNELIAS 12). ‘Ov mtd encmdicor so btn capac de rod mio a eeciddede Westra {oars ira A iio enim gerimente ont na tenia de medaments egress por ‘imate du met vi pawns (os) aumento de ‘Ovstrescisfeniamtnkn tres osmium ded oreo contin com? fae ged exe eae, em ue sas edieme- sons on fotetes no io na mute as fas endchna, coms cio maison. vider es pa lego. cpscaets em estos de doers pts, como ‘pune cnn New Sons oor scent (fo de nvidade ecm con ecoroca Se wf Sngincohepic rude icieia da snes Soin, acoso, porno. de jute de one 14 10 inden po iran ‘rman pe poze epi po ds Imecanimor de epatooxciade 22:1 Hepttxcdade deta em come. lado eta evods mac ou dor ses pron nels ‘Guns desenes darter Jo mesmo ao. {Eum du pei osctsnaen ex bore ecco ‘fein tran we ointment pln se reas ‘meubsies 6). Segundo ROBINS ct allo ges optus di ono eprtcscinan preva carte Po 'scenarc em mas os eps Depend da de ‘Nossnarem iene rane ct es ingen do race ag aes, bind args bps semelts en Hepa a einenensiie 4 rmog core em cased seni le tne dohnpels pend eum menial. em {gu ne ecm oto deena boro mews pre api tomo mum mv seme (12) Em dao inpesisel Povscinen s pecog recamme rade dle ea oo eens 8) Pr ROBINS eal ho apts henson a toon panics invite escape ")Aitrem menos eee, 1 Naw dpenacrem dose, Shapes ml ct expr 08 «a eqtnc de cores manta seis, come ere up cts oth Expl ren com v0 dso pb Sermo mam pelo ga parties daira opi ide ec ‘ovicinena oncicameno oscuro staracona inca oe sj cen au rato eric oe ‘rae tar cooler es) er nora a jrock umn aia moe "Carmo mann Shepard prac sao et opment vl sige amass Sa ‘Soume inners ne ml «or 2) 2. Leao medicaments Hedin ‘tcp frmacligis poe teria es tipo ee epi, ene msi at ‘a Farmaco dons nin pase ca epttoiade Sma qe tds dens bp ie aot o oe, ‘fom era Ess ees socom sponses fw ce de de tkon on ens enter om pases 19 Inform 07.118, 1999[NADPI NADI rads deousenzinas sistem 86 ‘De wn forma ris dead, sedans 5 ‘remem un fl ads Se fee ou pt ii, ‘eas guna de xt, edo ou ls poe ‘ormcte nfm om sepuna fe, chads de seca 2 ‘come (Nain de cone oarmaco alia ‘u sous mealton podem se conga com substcas (igen come o fon ain, incpanet, ‘Sn sao ltt, tmando sem plas posi Sas excep (12 13, ‘0 clence Repco de Krmacs adminis, in ea, doen isa Ss enimas ge os mtb, {is cee bars, do Man anes Repco € J 0 ‘ig «eam pln ‘sgencesar ube neo que ids cerns do site ede ino tsps Se a ‘ens samen quando nina Fev aen {tain combos eric cs runt oitiion.Rearoneo polis clogs © ‘uo outs agentes ge (10 1 indo eed po orem aon omen ins tems poate redid weeks de lf me (Semen, oracle sn gi. Um xemp ese ford merc x ane oncom ose Faves ewan, mies pict age como Inder ‘ini ere oe pido wari, Nai ‘Shap inne a neo So wart ee orca du pia melas. Enel, ganas [ntrempe sdminsragh do indo, velociaae Je ‘Nesters do wasn (atcaglae oa vlna er eal done aa au’ er tle pedo povcar ‘ave moma (1) ‘Seruno FOUTS (5), xs mals e 20 substi caus ede seme microsomal epic. Ee as polem-s eit: hipatcos ¢ sedatives (babies, ‘Comaraico), fungeias(grisofltna, elon, ‘hlpdémcen afento t sarincs ier, ‘antes macue crore des splc tah enertdes(hsecorter, angen, pope, ponicemines tusmid, crt, pscxicos ‘coon, nia), wos robe at ‘ours sbstneias (Rosigre pod MEIRELLES © (ORNELLASCI2) Poretolae eeu ene lveno dint, fem que ceon medicaments, como 0 Aldo” pra inosine, slopool, cnet ene ‘un, por mccanimos giver, ie ss encias got Intl macoOeoree Gorge pad MEIRELLES CoRNELIAS 12). ‘Ov mtd encmdicor so btn capac de rod mio a eeciddede Westra {oars ira A iio enim gerimente ont na tenia de medaments egress por ‘imate du met vi pawns (os) aumento de ‘Ovstrescisfeniamtnkn tres osmium ded oreo contin com? fae ged exe eae, em ue sas edieme- sons on fotetes no io na mute as fas endchna, coms cio maison. vider es pa lego. cpscaets em estos de doers pts, como ‘pune cnn New Sons oor scent (fo de nvidade ecm con ecoroca Se wf Sngincohepic rude icieia da snes Soin, acoso, porno. de jute de one 14 10 inden po iran ‘rman pe poze epi po ds Imecanimor de epatooxciade 22:1 Hepttxcdade deta em come. lado eta evods mac ou dor ses pron nels ‘Guns desenes darter Jo mesmo ao. {Eum du pei osctsnaen ex bore ecco ‘fein tran we ointment pln se reas ‘meubsies 6). Segundo ROBINS ct allo ges optus di ono eprtcscinan preva carte Po 'scenarc em mas os eps Depend da de ‘Nossnarem iene rane ct es ingen do race ag aes, bind args bps semelts en Hepa a einenensiie 4 rmog core em cased seni le tne dohnpels pend eum menial. em {gu ne ecm oto deena boro mews pre api tomo mum mv seme (12) Em dao inpesisel Povscinen s pecog recamme rade dle ea oo eens 8) Pr ROBINS eal ho apts henson a toon panics invite escape ")Aitrem menos eee, 1 Naw dpenacrem dose, Shapes ml ct expr 08 «a eqtnc de cores manta seis, come ere up cts oth Expl ren com v0 dso pb Sermo mam pelo ga parties daira opi ide ec ‘ovicinena oncicameno oscuro staracona inca oe sj cen au rato eric oe ‘rae tar cooler es) er nora a jrock umn aia moe "Carmo mann Shepard prac sao et opment vl sige amass Sa ‘Soume inners ne ml «or 2) 2. Leao medicaments Hedin ‘tcp frmacligis poe teria es tipo ee epi, ene msi at ‘a Farmaco dons nin pase ca epttoiade Sma qe tds dens bp ie aot o oe, ‘fom era Ess ees socom sponses fw ce de de tkon on ens enter om pases 19 Inform 07.118, 1999om cia ee eri ne ove wtlzada, via 6 admnstrapio, drag, asoci30 com seria cn eu cas eh ep itera wm Ser aan plo mip hea 8 ‘tm dagniceo ma pce. A ttn peace de pis mlasoain stm meen € enc vm Ye ica mensne det ego € bane uments 0 ‘Se vesadr pri mc vem cgi ‘circ nce ware et tan es om ag 8 ela tps © es claay ernie iets «o nrg do age Alem a 0 {SSeoevines do ahmed page eis foutateareindcemeuhiceodeuneeatoieces de ‘notre ainda compe C9. 24 Casing ds rages meds ee trade ners, onan pl au on tea ‘eg, levand » nano made ee re ton ites pelea. mss ee {nb com fia apres Sop dot i seve, cn sees pn gre pt a ‘Syne ers Gta ha. san wk is oes pas or medicaments Ta | REACOES MEDICAMENTOSAS HEPKTICAS "TPO DE REAGKO INPLICADO _[FIPO DE HEPATOTOXING MEDICAMENTO ‘COLESTASEPURAOUCANALICULAR | FREVISIVEL Tas agalan C~ 1 aanico ccnp on) cage ‘COLESTASE COMTESO DO HEATON | FREVIVEL Carpe, cic ager CIO OUHEPATOCANICULAR ‘Son sg nee, 6 me ‘ee sri, nn TEATORE PREV Teac ne ‘ECROSE ZONAL CENTROTORUTARY | PREVISTVEL Takeo, ccaniofn, ST NECROESTRNAGERAMAGEA | PRESET Halas, hoi, acta, wT TETTERGTN REST Titans oor a Ta sats, met ep TEPATTTECRONICAPERSISTENTE | PREVIIVEL ‘Mei dps, eset, Fann, THERATTTECRONICA NA FREE Ne ip ein eo ‘CRROSE PREVEIVEL ‘Means ga ca ep no “SINDROMEDEHUDICTTART TAREE Anco oy SRE a ELIOT HEPATICN REVIT Eee agua C1 aa ‘GRANOLONAS TOPERSERSTOTIONDE TT PREVTS Fenn, aia eT SSERAL) ulin print ‘ADENOMA DORTGABO TRESTEL Eerie aur C17 Gakic, a PERSIA NODULARTOCAT TRE Tetconcepcbeal aa ‘CARCINOMA HEPATOCELUTAR PREVISIVEL Ener abla C17 Gaakioo a FiBROSE BRENT Mette, eas does les TETTTETNPECTCA TPRENTSTVEL Terr THEPATTTEALCOGLICA BaENIVEL ae FONTES; ROBINS el (1): SHERLOCK (1 MADOREY (16 MEIRELLES © ORNELLAS (13) Iaforon 07.8 1A, 199 20ous considers se a ages hepa © msicaeton notion ional 0 Tl Ibe como ‘aoa cts mere Fhe come sem amos por (esas prs on ‘cosinor, steps por liga ocean hpatocllr (else om sto Repu a epatconese To pny cau, oan pra soled da ee pica cm eeridessnrognco aac e core ‘Se tlie © horminioeaolo 6, gemene, mas mot ‘Soe, ttre C17 uli A eg os een eer meno quando grandes oss oe a ini sng ders (Lowell Mayon {ud SHERLOCK Neseand nace banca oe co emp clrpromai «com o ett de evo. ‘\clrpomaina poe origina uma sade clinica « ‘evgutlopumente ence ise ir pi Se au spete 1228 ds Gens ge oan atime ‘Gscootvem esa (10, Nap he spun cow ase Tei So msc a lei he “hola um ode rca por cuts dos feotiasaios, come 4 promarion, mepting, Provogersin Kt ¢ Meron =pud SHERLOCK (10) Tn por cutfensaiacn cm oranda (Goropumi zum) saiseans Tare, 9 = tio pureminesaicio, atrofuratoes, exteomicoa, ‘sian (D alee soca cles © sumer da cleer dae sea da iin ‘ete ge ume ex inert (16) Crt por ame epee gots ofa, do dais pes 0 1) Macovetisla- sess ptn gn de potas ens om anes ei ei cr ‘isco. ty Micovescalar- pec equ gs de re ‘scone com aed de teal No tga guano tren, season pelo nto conor medanen amps ce Sova en comidrayo apse eet da eo ica rece sist aes, pr pln 2 ee liars tad, ua er que € fl mer 9+ Ico em am patent cancerso rected guint tuncoplises dei exhdvt 0 medanen pgm apn me so por apres leo claterait menos severe ge otcraps porcine cose daca {orden ras 19) ft ee quem mari ds (rece peer sna lo aumento dopa. ‘rgiaorcnctrtcr do re igs, PEDRAZZ (Ginna or efono oir: dumesqum poms ico anne conn por metres, Sua © "Selofofamia ste prints bogs wim como os dase de heaton ten, ci fe ‘ado um umes de esrogens ie tele aes ma. comp tambon des misao, No ent, se ‘nan nas # Sonate ein, iain 2 eng tl tae. No indo porduowo mires, akan sem ivndn smese de pra, lea paca. ‘Pov lippasons de taser gee removeme tees ‘botign 10) lo bp Semis pls tris ‘deepen «ocr er gusaesapeiores 1.087 fin rts, vs ennai Nos pases om > gabe casa ceca deve eam, ois ‘Stuns to css stents ao de rane hepa Log eal pod MEIRELLES (ORNELLAS 12). ‘Ac tetciims, a poduire iad hepsi, levam & alterngdr laboratorain, come elevagdo dat ‘immerses sin rb ee oat ea ‘alm dz awn rng do temps de ‘rowcmbne 15, Fn me aia ema do ccs ¢ cnet soa a nil eco tv (1) Or arden wllnde Cow ows ‘Soca sin omen, noi cn mr ‘Stems pices ers esas So do seca Sing sue va ne no ino prove blogincn ciflaca hep famine ingens pod NADOREY (16). 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Astepro om eo ‘pein ma ¢ mv in ‘Since ge pdeenor paca “Sermbings dsvonania coms amp semen storia nen ne poem a Dot sigma manmade or cen gin mia pin ori a unann dtmneanderees eee ‘ih cess runner inn» rap (oir 0) 2. Ne mh mac Hote 5k fant neon, pol aan oa Cerri ow secession dt ‘ine ed rade do nse Da mena forma 8 spain perm op semen do ese (Feng hepato nia (MADDREW)G. A ‘mo ic ose nesting ere doe ‘Seat conde sur eto cen 0 “Or aes derma pen co epic sgn ina po meeamentn ec en 8p ‘Snes non nes prope vt (10. Ve Soeeecech comes nmiine secs, ope ane ‘Suse pind 1 fan cae Ns te ae a tn ne srt oor ison segs d forse sea (16) ‘in means ple ar den i ex oped hversperpos ee a eg Oe hp soot ete cee © sce Bas epic ‘Ste ous eo soir» ta po bor 5. fre cinco Hose balopet eo = Fae some de ome ei ama ve goo ES scaenea iene eptecrnesanaopaten ‘0 aa ones fo primero meinen ‘punt srt fw do mrad nt "ini dts 10) Atos pce an ‘nmr ema inc a co men por mia encenese 9. Fm terms genic para ws docs Hein Tibet cou boo Bol Soca me moa ac ‘sens progress ps case podem eco ‘pnd pte doses ‘Oneness chong, sh to a esse pate ais exia m do mevaer 2.47 Sine ead Car tani cores sone doe enc, ums ‘equ oe crt a as bps Fl ssa ‘tne ami em conse eee Fe fms ses Ress orale pan ph Asem cl de eves micas (10) Ha ecg ab ‘cca como ao dane (10 as ‘iieplices coms eames epi 16. 248 Row hepa ‘Eales cont em gine cian chin st marina het pen 8 eve orl sma Zante SHERLOCK 10) hepa inno de poss ius mas senses co ese ets lees hepsi, per COMO aqua prane mar os emacs ao oo aera flomoor um anc o eon das roves Bums epee (10) Sozmds KAHN (2 dei soapefamen dos lasrunenor ee bers, ean a ‘ions expo, no eta te xo pe, pore ov medicaments Interferom nests resultados, Emucsogcameme no) Seumicamet (vin ‘Nereis fn, cn Beene stam 99 ngsisme, snpremetn fig evan her 5 road fn Bp, os eu reo poo com Foner Mogens sine hepatic aera, on Tindoa wn alk gato 0 qe oa maa ee fue conos motes cont pninas ani Meccan atemstn oc vocal a perio lan sinters ds ileus [pom ner d 100 mim, 0 eng espcvame ‘supra ets eptcls, pen eve pei sb pull neyo abla 2) ‘Nee poder, PEDRAZZI ta (20) ‘um ingrid alsa eee noemages 9 tne tanec ¢o bea 30 do dearer Fil pla ata aorta, argu memo oe ‘Sts cle mas agenda par cade pei, oma ‘equ um edaments pode rin so mama ove ‘nl pis por mean es xe ‘aatandedo sat abbas, ee ole ra ‘opr dis meant deg "Depron = por ocloraeic lr Tame iol, e no (bel 2) obs do aor por ago dean a scepter sanomida, eae ones fi Sep PEDRAZZ1 (2) 0 cosines do mec shod pr ute do cline ingot po 4b en delta que eso sobre ace 0 tetra condo ieee em endo, ue go ‘hina ater pov borate occ e+ Siem, ini ou spend a dng pera. Pa LUBRAN (2) macs pk aa = tes ein bp ev de ep (00) ‘Stes No enna or efetos os tole oa ‘laos em alent somes 3 dca ‘ens com dno epi pe “Antero poe comple guano un me- amet ees cerai ae beers {recog do inn, Neves aon, alr Sherlo ‘se ges cotter qr dian eta d el {de quo i pte orm neces, ma ‘ol straint ds das aerate) eines nor omen 09-4 ‘ni nerge coms meta lis de um te ge ‘Sie, pendo ser guns 0 ca). Ta merece qui meant pode rage como mai crmpin, to rb poe a {pinica plese senses lean reads Ps lg retesHoginios termi por mus ew ei mali, osname pose ere im apenar vm eee Bo gee scare, po excl. com {eracline qe em fuga one, ler vss a ‘bin nce ua uncle ado de Sie 2 Toferme v7. 1° 18, 1999Borge clin oem de st ono acer trate meen, n nun, gas nbn ‘tiated oy Evy aces ‘Scere eto Pree cto eg ‘unicorn sooner enna com cing ‘masta, cao a se 3 ili mp nr ‘aime wn pal Je @ hr ah ‘evens 0 7 Gone. go ane derma seme ht gen te ts ‘Stamens an abel ngs odie cane cro do tanh (AAS Es nde pet ‘Seno amiga zea ed ns et Sr tien de Gomorra [02 0 pd {so to overstate arin em er {pre tomo stint ax eH a cei ee 4h (nc eo 500 2 {ltginl cn) inemperm ono sep ante fetal, oan ss one bil teen en sm asap cc sn es is ace mr ome ‘Semone como als eg ao care Smt de ast & Ghoul send 6 ‘im rl 6 AAS ee ean apn de Intec ry mi tera ‘i, or eae cers sever, ote ‘pastas aera, ana pros uo) “Epon eirarap tren mean noir > rena um exe arto a roa do ate pt outermost ue Foe! meer no mols Scent dn oes Ios ee pas pwn ain area a tncaso poses Na ime ic, on melee oe Seca ue sole fi! Ge qos parte biotic. Os cents Come iin Pihomacaapny, Yracenia ¢scflspras {Rete Kef encontrar aera pot ‘merit tr ( a i merci mst ao sini. men ano un depend nel epics © ssa re ‘ih mime corvette coe ‘hcloicom ane S150 ng ec ngs Sisco hl ea un Sib PEDRAZZI 2 in pon eno ‘epider, aang repo copie, ‘tec rapocttar sure dS IDAs Soa 0 ‘X'Evesu apn cecal ue 6 mola tne dt ‘Seminars io, uci pumas deco fe Pics como 1 fous cine, a ain {Sim tl antes paa met (0m) em peo Resa Pole. aim em Sue oo ee, emi ngs i eras eg Ge os <2 ed ps, rls os tenes ons neon acer cs guess PEDRAZZI HOSTS, a ein Tefen 11999 ‘emo ales de abs do 9 te sr cm "iti Ox mss de Rac Fel pus guns ‘es aminceanerses ey de Eh pr quan) ‘iain ster ago nvr ifn, Spec ve se tm oo eee import nour gue mo ao einer i. maton pry echt pote as ena qu san mere on eh exiinn, ert, ore. 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Apens te elecins tere neo, sezind a FCC deranal ee of Che hemi {All dino, etter code cones Je "tetas no que ara concent ahs ‘ethics tr gs Het ona “ise bral 18, i gio malin pos rine pec lin, npesnel goo mes ei cl ‘a ce te a ec fimaroige do meca come or etn: i Pe sve do madamenin don frm! gen, Sete maim ‘etre anon nant oi Nese tn casa ee ‘acs de uaa primera to on ‘ei aa eo dass aor cee ‘lente, foray ares 2 sie 232 ‘Segnio WIREC» THOMPSON (3), penal ade vag ait on ata seo et ‘ze cans soi mo tm ew sone a ‘ones lige do kn dasnend doen ‘eto macoipes Jo metcenenin nana, ee Apa deiner pais aliases te, © ‘nt in ce in ee, ae ‘ee ins name ibrwa O mae co te ‘Straten prs rn pe depres ges 24se. pip, propre mia was gue, m9 alleges ma alies errs poeram io fa Snipes, pteronaens ture Yabo evaniea jaime, bse no onesie Gumi, farmacces ‘fle dagniniee dcuanio come clica in. fsa wcolgiads fas pr seen sa ‘in do pace ‘tag eapcfins No cata sraroprs ors ers BRODY G4) em 197), i witaa qe a pcwsio jas expends deve pigment 4 ent om posse nemtes ecaneioas ¢ combos muro de mve acs, a pete etn Tels 2 INTERFERENCIA DE FARMACOS NAS PROVAS DE FUNCHO HEPATICA I ioe vivo DOSANGUE TILIRAUBINAS _ ) AGAOHEPATOTOXICA [Xcdo amiobsnzico, Anftricine B, Aspidlm, Azatiogrine, Hesiogroe, Carenoxlone Car, Canaria, Catania, Contac, Clean, ‘Garde, Gort ‘Clcneiian, Oormoxaone, lott, Cetera ‘Genes Gelpeyno. Cumann, Cones arcs Cafes, Detainee ‘ci stern nl, Faure bli rami Ebceea,Fenstiae ‘howimesterons, Floanidine.Flrastan, Flaten. Feasting, Fenbata Fesonpoparia, Gena Halper, Hunacetamia, Acs Span, ‘Kanicna. Lincomicna Metbesamida Metatlona Met-Dop, Metaweste, ‘Metal, Metouiaraa, Metowusimida, Nivafurans Osan, Oxasepn Osten, Pallet Parents bere Pon, Pena (iamsian, Toto, Use, Ue, Tower, Tobi FARMACOS QUE PROVOCAM EFEITOS FISIOLOGICOS 0) + 2) AGAOCOLESTATICA ‘Acotexomi, Acsefenazin, Acido aminousctico, Aneigenon, Assia, ‘Anablico ence, Bataperain. Cabazon, Carfearina,Chorarepsio, Clorpomasins, Clorinfenical,Cloroiantda,Clopropamida_Clopatxen, ‘Gels, Cart, Dettoting, Dens, stl, Espen, Eston ‘Ehromicin, Hrctcaasd, Hirota, tipaminaindomea Tprolrid,soetoxne nid incor, Mepuia, Mepetamat, Meunis, Meinazsle, Meundronsrose, Meteosat, Metis, Acco ‘lis, Niven Nitra, Notandloe, Norn, Neon, ‘onipilns, Oleadomising, Contactos eras Oxinetaons, Promainn, ‘romain,’ Propolne, Festarins,Guneasoea,Slfadrin,Sltnetin ‘Swvlonamidas,Tesoxerons,Teactlina, Tacearos, Tara, Tepes ‘gui, Thai Toland, Tatas Tend, Tian, Vis es ARMACOSQUEINSTERFEREM NA METODOLOGIA vin) TNR, RTaTERRENRONEROORMATZARORRA TOASTS ‘nt Ad athe eee mnt Lanse: roe 2iisnmrenfnca NoMETODO BE MALOW EEN Dae maa x 5 INTERFERENCTA NA DIAZORREACRODE UM MOO GERAL Raum een Hasenstein, Rinne metres X FARMACOS QUE PROVOCAM EFEITDS FISIOLOGICOS dn vo) ae FOSFATASE ALCALINA IVACADHEPSTOTOXICA Aza, Caran, Meters 6 Meaopr Met Dop Noon, ‘estar Alri, Aseria B, Cellar DaGAOCOLESTATICA Acccboamis, Arbors andopoios, Charopanid, Ein, Contain PogexrenaEsesnn, Tle, bem As Amini ‘SImiprins,Indonetcn, old, Litcomicins, Metis Nite, ‘Ob Tonos mace} desert Tis I elon com eases cane ‘ss hepi, terre fsapamene mas pos de eg epi Oca do iteans, Accs, Sis, penania cata bce Pepe 25 Unfareney v7.19 1/4, 1999FARMACOS QUE INTERFEREM Na METODOLOGIA ev) Este pac fms ue inert coma me da nun sala, A woe pa nie 3s Ginn Po ei Ane am Paes Nn, xa sung fe Poin esses "EFETOSFISIOLOGICOS (nwo) {DH PEDRAZZ (20 wo ces casas dn jena algun sna yoo moras Ran € klofoiid.o gis preenarim fe hws, end sum ume Sesame cts oc Iwnimas LD © LDS ain ar anima [COMPONENTES Do SANGUIE FARAIACOS QUE INTERFEREM NA METODOLOGIA Gsm) 1H ‘oxalate said cca ARRMACOS QUEPROVOCAM EFEFTOS FISTOLOGICOS Gamo) TRANSrERASES DANO HEPATOCELLULAR ASPARIAT Aco tsi, Alu Api, Aion, cio ans AMINOTRANSTERASE (AST) — Sati, Avorn Ap Artie Beteoaene Cat LAWINA Zepina, Cabereciins, Carbtanin” Clraneneel Clotate, ANINITRANSHERASE (a7) Gian Canc Chri, Dade Hulcro, Haren Tens Instn, Iai onda Kanamiciny, Licomiia, Mercpnpuia Mctecing, Meat Netoralen,Metoifirane, Mein, Metra Nouri CConracepvos ern, Orca, Orcas, Onfensana, Papen ‘Acido. preamiaobenabien, Paracetamol, Parldeldo ili emunptidn, Tenbtrom, Protec. cseamia Popo Pravin, Quai, ifsc Testcons Tea Tale ‘ai Tancionny, eet, Teton Texans 2achocouesrénica Acstheamids, Actes, Anita Andrgen, Raper, atnazspit,Crnfie Chait Crp. Dev nie DifeaIdarein, Etenamid, Exes anaelice, Imani Indoncticis.Lnconicn, Mepobara, Mando, Mundo Mtiesssona, Aco sic Ado neste, Niele ‘Nortandrolne. Notinarons, Novobicin, Ocal, Oeston Grp vis Oxnatolona, Feiadoes, Fens Fei om Testa, rckepeana, Poti. Psi Quieres =e eee a ee a Soreness ARMACOSQUEINTERFEREMNAMODOLOGAaim) + TRANSFERASES TuNTERIERINCIA Na DETERNINAGNORSPOCTIOFOTOMETRICADAAST fadbttea tab penuenales tame ae x Oh Gy rs one aes men ee ee ee ROTEINASTOTAISFARMACOS QUEROVOCAM EFEITOSSIOLOGICOS. yaa ‘DAGhOWEPATOTORICA erie, anni, Rump see mimi depois sis). X ae set Rese elle ah ae Se ees efron v7.18, 1999 26TFARRACOS QUEINTERFEREM NA METODOLOGIA Giro) = ‘)EFEITO DE TURBIDEZ 2) INTERFERENCIA NA COR Fens, Sutra x FARBIACOS QUE FKOVOCAM EFEITOS FISIOLOGICOS in) + DACAOHERATOTONICA -Actibexanid, Esters abs, Clap, Clopromsin, Clarropa: id Contre, aon, EDTA, Hota Measina Meant, Meshes. X ‘overt Nac, Prrperain, Promasina, Sulfate, Teac Tard, X ‘orm, Tis, Tetuoprn x TONES FEDRAZZ,PEDRAZZ« ROSSI 0, STATLANDe WINKS; CHRISTIAN: LHANSTENSS: CONSTANTINO c KABATIS: ELKING e ABATS2, SHERI, LUBRANZ, "Tal 5 SIVTESE DA IVTERFERENCIA DE FARMACOS NAS PROVAS DE FUNCAO HEPATICA TaRMACOSE FOSATASE | oumausna | swan | JEMPODE ‘couPosto D0 AALCALINA ROTROMINA ESTEROINES ANABOLICOS : ° : saxonoceNos o Ennnoocna 3 : to . ‘Setmasranacos canna ? : Clot ° : : ‘Soanorsbe 8 : oven 3 : Cormeostexoies ‘ ; Desamastonss 3 ‘Reoxatoeco J : - ‘conieuriieo.) © a SiteorimanTos 4 6 Sere eine cen rein Vehp eee mepmcaenes Om Oe 7 Tepes aiANN cetera = 7. 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Em comeyitcn dn agi meconenos epics pec € importante. rarmicnsomoaetnes | mn eentumntert eee eee nak meted ey Se ean Tree eee aetna Resende emsnaapnas ee en tn cnt tet Ame ne '98 ‘AER Devon DH atmos mee ees aie! CASA, eR nnd NE ea be ee Seen ae ee ee SRR wnkae A getName waite aeetre mamta mtr ae em Serer aS thinning “amin EC tg Agar a Pa, 7, oman ee ‘Signup es Cn a Informa, 07.1 A, 1999 26