Professional Documents
Culture Documents
In its severest form, developmental dysplasia of the hip is one of the most common congenital malformations. The Lancet 2007; 369: 1541–52
pathophysiology and natural history of the range of morphological and clinical disorders that constitute developmental Centre of Epidemiology for
dysplasia of the hip are poorly understood. Neonatal screening programmes, based on clinical screening examinations, Child Health, Institute of Child
Health, London, UK
have been established for more than 40 years but their effectiveness remains controversial. Whereas systematic
(Prof C Dezateux FMedSci);
sonographic imaging of newborn and young infants has afforded insights into normal and abnormal hip development Section for Radiology,
in early life, we do not clearly understand the longer-term outcomes of developmental hip dysplasia, its contribution University of Bergen, Bergen,
to premature degenerative hip disorders in adult life, and the benefits and harms of newborn screening. High quality Norway; and Department of
Imaging, Great Ormond Street
studies of the adult outcomes of developmental hip dysplasia and the childhood origins of early degenerative hip
Hospital for Children, London,
disease are needed, as are randomised trials to assess the effectiveness and safety of neonatal screening and early UK (Prof K Rosendahl PhD)
treatment. Correspondence to:
Prof Carol Dezateux
Introduction need to know whether stable but mildly dysplastic hips in Medical Research Council Centre
of Epidemiology for Child Health,
Developmental dysplasia of the hip is an important cause childhood and adolescence have implications for hip
Institute of Child Health,
of childhood disability. This disorder underlies up to 9% function and risk of osteoarthritis in adult life. University College London,
of all primary hip replacements and up to 29% of those 30 Guilford Street, London
in people aged 60 years and younger.6 Developments in Diagnosis WC1N 1EH, UK
c.dezateux@ich.ucl.ac.uk
ultrasound imaging have lent developmental hip Dislocation and subluxation can be diagnosed through
dysplasia a greater prominence in recent years: in several clinical examination, but some form of imaging is
European countries, all newborn infants routinely necessary for the diagnosis of stable acetabular dysplasia.10
undergo ultrasonography. One consequence of routine Distinction should be made between tests suitable for
ultrasonographic screening has been a pronounced screening whole populations of newborn infants, and
increase in treatment of neonates, which arises from those for assessment of individuals who are suspected,
clinical uncertainty about the management of on the basis of a clinical examination, to have
ultrasonography findings. The benefits and disadvantages developmental dysplasia. Only a few studies have
of different screening and treatment policies are difficult addressed the clinical validity of screening for hip
to address because of inconsistency in case definitions, instability separately from hip dysplasia.11,12
variation in methods of ascertainment, poor quality of
most studies, and absence of evidence from randomised Clinical examination
trials. We discuss the reliability of different screening Clinical hip instability in newborn infants was first
and diagnostic tests, before reviewing the epidemiology reported in 1879.13 A clinical test for assessment of hip
of developmental dysplasia of the hip; its prevalence, instability was described by Le Damany and Saiget in
aetiology, and natural history; treatment; late sequelae; 1910 and brought to prominence in 1937 by Ortolani.14,15
and secondary prevention through screening. We also Further tests to provoke dislocation or subluxation were
consider challenges for future research about this developed by Palmén in 1961 and by Barlow in 1962.16,17
disorder.
Developmental dysplasia of the hip refers to a range of
developmental hip disorders—from a hip that is mildly Search strategy and selection criteria
dysplastic, concentrically located, and stable, to one that We searched PubMed for articles published on developmental dysplasia of the hip during
is severely dysplastic and dislocated.7 Mild dysplasia the past 40 years (1966–2006) with MeSH terms “hip dislocation” and “congenital”. Our
might never manifest clinically, or might not become search strategies were modified from those developed for a previous systematic review.1
clinically apparent until adult life, whereas severe We searched using the terms “developmental dysplasia of the hip” or “(hip AND dysplas*)”,
dysplasia is most likely to present clinically in later and pooled the results. We referred to papers in databases that we had previously compiled
infancy or early childhood.8 In a dislocated or subluxated through research and associated systematic literature searches, and searched the reference
hip the femoral head is completely or partly displaced lists of other relevant published systematic reviews.1–5 In preparation of this Seminar, we
from the acetabulum: this disorder can be associated focused on publications from the past 10 years, but did not exclude commonly referenced
with secondary acetabular dysplasia, whether or not the and highly regarded older publications. We also selected relevant papers from the
dislocation or subluxation persists. In a stable dysplastic reference lists of articles identified by this search strategy. We have cited articles that meet
hip, the acetabulum is dysplastic but the femoral head is accepted quality standards for design and reporting—namely, randomised controlled trials
stable and not displaced. These disorders might share where available and relevant, or other well designed prospective observational studies
the same antecedents, but further research is needed, reporting prevalence, aetiology, or assessment of diagnosis, screening, treatment, or
especially to find out whether stable acetabular dysplasia clinical outcomes. Review articles and book chapters are also cited to provide readers with
in late adolescence is preceded by dysplasia or instability more details and references than this Seminar allows.
in infancy, or is modifiable by early treatment.9 We also
categories, on the basis of features of the acetabulum, the Values below 47% for boys and 44% for girls are regarded
bony modelling, and the cartilage roof (figures 1 and 2). as pathological.54,55
However, these morphological appearances represent a The method used to assess ultrasound images from
continuum from normal to severe dysplasia, rather than screening of unselected neonates affects the reported
four distinctive groups. Further, indications or thresholds prevalence of various features of hip; these are summarised
for treatment remain controversial: some investigators in the table.54,56–62 Variation between studies might stem
monitor children with type 2a hips and treat those with 2c from differences in diagnostic criteria; in age and
or D hips, whereas others follow cases of type 2c and D population studied; and in image acquisition, processing,
hips and treat types 3 and 4.11,47–51 and analysis. The interobserver and intraobserver
Despite these limitations, Graf’s method has gained reliability of the Graf classification has been reported as
acceptance throughout most of Europe, albeit with moderate to good for normal hips, but as poor for
modifications. For example, Rosendahl and colleagues abnormal and borderline abnormal hips, especially in
have adapted Graf’s method so that it assesses hip studies in which the clinical findings and history associated
morphology and hip stability separately, to distinguish with such cases were not revealed to examiners.23,54,63–68
their relative importance for treatment outcome.52 Whether reliability can be improved by standardised
Harcke,45 Novick,53 and their co-workers have reported a training is unclear, since in one study performance was
dynamic multiplanar approach, that emphasises hip unrelated to previous training or experience.66
stability and the positional relation between the femoral Controversy about the natural history of these findings
head and the acetabulum, and classifies each hip as relates to the inadequate follow-up of screened infants in
normal, subluxated, or dislocated. Morin46 has proposed a all categories and the scarcity of well designed prospective
technique for assessment of the extent of lateralisation of studies. Hips regarded as normal in the neonatal period
the femoral head to show the proportion of the femoral are likely to remain normal,11,69–71 and more importantly,
head covered by the bony acetabulum. Terjesen54,55 has more than 90% of immature hips will have improved by
modified this method to measure the so-called bony-rim 3 months of age.72–75 Despite these findings, some
percentage, later termed the femoral-head coverage. investigators argue that sonographically immature hips
Technique or grading Number of infants Graf type 1 or stable Graf type 2a or low femoral Graf type 2c or D or dislocatable or Graf type 3 or 4 or dislocated or
system screened or normal (%) head coverage (%) lower femoral head coverage (%) lowest femoral head coverage (%)
198656 Morphology (Graf) 1001 – 2·3 – 0·2
198857 Morphology (Graf) 615 84·7 13·0 2·0 0·3
199158 Morphology (Graf) 1292 40·1 56·6 3·3*
1996†59 Morphology and instability 3613 83·6 13·0 2·7 0·7
(modified Graf)
1997‡60 Morphology (Graf) 4648 50·1 44·8 4·5 0·6
1994§54 Femoral head coverage 4459 95·9 2·9 1·2 –
(modified Morin)
199461 Bony rim percentage 14 050 93·9 6·0 – 0·09
(Harcke/Morin)
199562 Anterior Dynamic 4430 – 1·0 – 0·09
*Graf 2c or D and type 3 or 4. †A dislocatable femoral head was found in 0·1% of the normal and 0·6% of the immature hips, while a dislocatable or dislocated femoral head was seen in 62% of the minor
dysplastic and in 100% of the major dysplastic hips. ‡The distribution of different types varied substantially between the six different hospitals involved in the study.
Table: Studies reporting prevalence of ultrasonographic hip abnormalities from universal screening programmes in unselected newborn populations
and femoral head, but such development is often perturbed unscreened populations the median prevalence of
in the course of surgical or non-surgical treatment in persistent and clinically diagnosed hip dysplasia is
childhood. The resulting disturbances of growth in the estimated to be 1·3 per 1000 (range 0·84 to 1·5) on the
proximal femur are defined radiologically as avascular or basis of a rigorous review of studies from 44 unscreened
aseptic necrosis of the femoral head, although there is little populations of predominantly northwest European
pathological evidence for a vascular mechanism.103 Growth ancestry living in Australia, the USA, Canada, Scandinavia,
disturbances are a recognised complication of surgery, and and the UK.24 The prevalence of neonatal clinical hip
an iatrogenic complication of abduction splinting.96,104 In instability detected through the Ortolani and Barlow
children with unilateral hip dysplasia, disturbance of manoeuvres is higher—it ranges from 1·6 to 28·5 per
growth in the proximal femur has been reported in the 1000.24 Thus, neonatal hip instability, ascertained through
initially normal contralateral hip.96,104 Radiological scoring clinical screening programmes, is considerably more
systems for avascular necrosis include Kalamchi and common than clinically diagnosed hip dysplasia. This
McEwen’s widely used classification, which is based on an finding is consistent with suggestions that hip instability
assessment of damage to the ossific nucleus and the is transient and resolves spontaneously in the first few
physis.105 One study has reported that this classification is weeks of life. The prevalence of ultrasonographically
highly reliable, and another has reported that it can predict detected hip dysplasia in newborn populations in which
poor function at skeletal maturity.106,107 The frequency of ultrasound has been used as a primary screening test is
avascular necrosis in hips after operative procedures even higher; it ranges between 34·0 and 60·3 per 1000 for
ranges from 5 to 60%, and after non-surgical treatment, studies that apply a morphological classification.11,54,55,61
from 0 to 14%.96,108 However, these findings might not be The variation in prevalence, together with information on
directly comparable, since several studies did not have the natural history of these ultrasonographic appearances,
adequate length of follow-up, and the studies differed in emphasises that developmental dysplasia of the hip
losses to follow-up and in the exact definition and scoring cannot be diagnosed on the basis of one neonatal clinical
system used.109 or sonographic screening assessment, since both are
Despite the limitations of the Severin score, it has been associated with false-positive diagnoses.
used in the few studies of adult outcomes in surgically Developmental dysplasia of the hip is most common in
treated developmental dysplasia of the hip.91,93–95 Both the girls.116 Ethnic variation in the prevalence of dislocation
acetabular index, assessed 2 or more years after hip and subluxation in unscreened populations has been
reduction, and the Severin classification at skeletal maturity reported, with notably higher rates in Japanese, Turkish,
have been reported to predict future need for total hip Amerindian, and Lapp populations.24,117–119 The acetabular
replacement or arthrodesis.95,96,110 These findings could be dimensions of Japanese people are shallower than those
interpreted as supportive of a link between early acetabular of British people, and their rates of osteoarthritis are also
remodelling, residual dysplasia at skeletal maturity, and lower.120
the long-term risk of degenerative change, but In the past, without detection by screening,
methodological limitations include small sample size, low developmental dysplasia of the hip usually presented
reliability of the outcome measure, and in some studies clinically after walking age, and at least 50% of patients
absence of blinded assessment. Thus, cautious started treatment by 5 years of age.121 The recognised
interpretation is needed. longer-term complications of untreated developmental
The limitations of two-dimensional assessments of the dysplasia of the hip include pain in the hip, knee, and
hip and femur have increasingly been recognised, not least lower back; disturbances of gait; and degenerative
because of the challenges of total hip replacement in changes in the hip joint. However, the risk of such
severely dysplastic hips.111,112 In some centres, computed complications is not well defined. Some reports suggest
tomography is used to define proximal femoral deformity that, without treatment, functional impairment due to
and the extent of femoral neck anteversion and acetabular developmental dysplasia of the hip is common, and that
anteversion before total hip replacement in young it increases with age but is not inevitable.42,121,122 When
adults.111,113–115 This technique is not recommended for followed up for an average of 50 years, 11–41% of those
young children as the necessary doses of ionising radiation with untreated dislocation remained free of pain.42,121,122
are greater than those used in radiography.84 Magnetic Some evidence suggests that patients with untreated
resonance imaging can allow assessment of hip and subluxation or a false acetabulum have a poor functional
acetabular alignment, and depiction of hip anatomy, and prognosis, with onset of pain on average 10 years earlier
although at present preschool-aged children must be with a false acetabulum than with untreated subluxation
sedated for this method, it is potentially useful in older alone.42,123,124 However, the outcome of untreated acetabular
children. dysplasia in the absence of dislocation or subluxation is
difficult to assess since ascertainment is likely to be
Epidemiology incomplete. Dysplasia has been reported in those with
The prevalence of developmental dysplasia of the hip degenerative hip-joint disease, but childhood dysplasia
varies with age and method of case ascertainment. In does not invariably persist.117
not require direct surgery to the hip joint to more invasive dislocation, subluxation, and evidence of growth
procedures, such as acetabuloplasty and femoral or pelvic disturbance on follow-up.
osteotomies. Sometimes more than one operation is Proximal-femoral growth disturbance, defined
needed. These various approaches are used on the basis radiologically as avascular necrosis, affects up to 60% of
of expert opinion and of selected small case series from treated hips in some series.108 Some investigators suggest
single centres that report the radiological outcomes of that the risk of this complication is reduced by better
specific procedures.1 preoperative management, including the use of
preoperative skin traction and the so-called human
Outcomes of developmental dysplasia of the hip position during postoperative immobilisation.145,146
Long-term follow-up to skeletal maturity and beyond is However, the effectiveness of preoperative skin traction
needed to identify the functional outcomes of has not been rigorously tested or proven, despite
developmental dysplasia of the hip and its treatment, widespread adoption of this practice in the USA and
since a hip that is anatomically and radiologically poor other countries.103
can function well during childhood and adolescence but Another way to assess the longer-term outcome of
later become symptomatic.91,96 The few reports of small developmental dysplasia of the hip is to quantify its
selected case series that provide information about adult contribution to the need for total hip replacement within
outcomes of treatment are, by definition, unrepresentative a population, especially in young adults. However,
of contemporary approaches to early detection and obvious limitations include selection biases in relation to
management.109 demand for, or access to, treatment. Data from the
Reported outcomes of abduction splinting are difficult Norwegian Arthroplasty Register,6 which includes
to interpret in the absence of a randomised control group, information on 72 301 hip replacements undertaken over
and most observational studies have methodological a 15-year period, show that about 1·0% and 7·6% of all
weaknesses.1,2,4,5 In a large prospective observational study hip replacements resulted from congenital hip disorders
of 221 children with 12% loss to follow-up, 12 (5%) of or dysplasia respectively. In people younger than 60 years,
those treated with abduction splinting needed surgery, these proportions were greater: about 4·8% for congenital
and by 5 years of age, 7 (3%) had signs of acetabular hip disorders and 24·0% for dysplasia, with a female
dysplasia, and 1 (1%) signs of avascular necrosis.144 These excess at all ages.6
estimates are comparable to those of other case series
reviewed in a recent decision analysis, but significant Screening
biases in assessment cannot be excluded.1 These caveats Screening of newborn infants is based on the premise
also apply to reports of outcome after surgical procedures. that if developmental dysplasia of the hip is not diagnosed
Radiological evidence of osteoarthritis was noted in more clinically until after walking age, it is likely to need
than half those treated 10–50 years earlier, of whom half complex surgical treatment and the outcome is likely to
had developed hip pain by 40 years of age.121 In this study, be less favourable than if it were diagnosed earlier. This
clinical and radiological outcome was assessed as good or rationale also assumes that early diagnosis and treatment
better in 78% of unilateral and 51% of bilateral can promote normal hip development and prevent
dislocations, but in only 28% of those treated after 3 years premature osteoarthritis associated with clinical
of age. The prognosis for those treated by open procedures presentation of developmental dysplasia of the hip.
seems to have improved over time: in the earliest series Systematic clinical screening of neonates has been
of hips treated by open reduction some 20 years practised now for more than half a century in European
previously, only a fifth were radiologically normal and countries,16,17 with ultrasound screening of whole
slightly more than half were free of avascular necrosis, populations introduced in Austria and Germany in the
compared with 51–78% and 98% respectively in more 1980s and 1990s.147,148 In some centres, ultrasound is used
recent case series.30 In two cohorts followed up for a to assess those with clinically detected hip instability or
mean duration of 30 and 33 years, respectively, the with recognised specific risk factors for developmental
outcomes were reportedly similar95,96 One study, of a dysplasia of the hip, such as breech delivery and a positive
cohort of 119 patients diagnosed and treated between family history.149–151
1938 and 1969, and followed up at a mean age of 31 years, The challenges that arise from the scarcity of robust
noted disturbed proximal femoral growth in 91 patients evidence to inform screening policies for developmental
(60%), degenerative hip disease in 65 (43%), and total hip dysplasia of the hip are well rehearsed. The outcomes of
replacements in 17 (11%) of 152 hips.96 In another cohort, clinical screening have never been compared in a
of 147 patients diagnosed and treated between 1947 and randomised trial with those of clinical diagnosis or of no
1965 and followed up at a mean age of 36 years, the screening.9,152 Furthermore, the effectiveness of screening
findings were similar: moderate to severe osteoarthritis programmes cannot be assessed directly, because we do
in 78 (41%) and total hip replacement or arthrodesis in 27 not have a diagnostic test to distinguish infants who are
(14%) of 191 hips.95 Features associated with a poorer truly affected from those who are not. Thus, clinical
prognosis included older age at operation, high screening is associated with potential overtreatment of
children with false-positive screening results, and with Several studies have examined the cost-effectiveness of
failures of screening, diagnosis, and treatment in those different primary screening strategies for developmental
who do have developmental dysplasia.153 dysplasia of the hip, but with one exception29 these have
Much uncertainty also surrounds the clinical not assessed longer-term outcomes, and none has reported
effectiveness and safety of screening programmes based quality-adjusted life years as an outcome.4 In a decision
on ultrasound examination. Two randomised trials have analysis based on UK data, Brown and co-workers29
addressed primary ultrasound screening but neither has suggested that uncertainties in the cost- effectiveness of
compared it with a strategy of no screening.11,71 In a study screening mirrored uncertainties in the evidence regarding
comparing clinical screening alone with a combination its clinical effectiveness. Cost- effectiveness was affected
of clinical screening and universal or targeted ultrasound, by assumptions about the long-term outcomes of surgical
Rosendahl and colleagues reported higher rates of treatment and the proportion of infants treated with
abduction splinting and follow-up in the universal abduction splinting appliances. The most robust economic
ultrasound group due to inconclusive early ultrasound analysis was based on a randomised trial in the UK,139 and
findings.11 Although fewer children screened with assessed costs associated with the use of ultrasonography
universal ultrasound presented with late subluxation or for the diagnosis and management of neonatal hip
dislocation, this difference was not statistically significant. instability, and concluded that this use of ultrasonography
Holen and colleagues71 reported similar findings in a trial was unlikely to impose an increased cost burden and
comparing clinical screening and universal ultrasound could reduce costs to health services and families.159
with clinical screening and targeted ultrasound, and
recommended that ultrasound should be used only for Future directions
those with clinical hip instability or recognised risk In 1984, screening for developmental dysplasia of the hip
factors. was famously described in the pages of the Lancet as a
The prevalence of later surgical treatment for “mess”.160 Some 20 years later the authors of a systematic
developmental dysplasia of the hip in those not detected review concluded that “general screening of newborn
by screening has been used as a surrogate measure of infants for [developmental dysplasia of the hip] provides
outcome of screening. The rate of later surgical treatment us with a good example of how early acceptance of an
ranges from 0·07 to 1·79 per 1000 (median 0·45) in intervention or technology can inhibit or even preclude
different countries with clinical screening programmes.24 good quality research, resulting in long term—if not
This variation probably indicates methodological permanent—uncertainty”.5 This conclusion is consistent
differences in definition of surgical treatment, with the findings of other systematic reviews of clinical
completeness of ascertainment and duration of follow-up, and ultrasound screening.1,2–5,29 However, no countries
and differences between populations and in the quality have abandoned their established clinical screening
of screening programmes.9,36,140,154–156 The equivalent programmes, although some have decided not to add
estimate for screening programmes based on primary universal ultrasound screening.2,4,161
ultrasound has been less extensively reported. A study Where will we be 20 years from now? We will probably
from Germany that used similar methods to the UK know more about the genetic control of acetabular
MRC study of clinical screening, showed an development and hip stability and its implications for
ascertainment-adjusted first operative procedure rate of adult hip health. An essential prerequisite for this
0·26 per 1000 livebirths (95% CI: 0·22–0·32) after knowledge will be careful cross-sectional and longitudinal
ultrasonographic screening, compared with the phenotypic assessment of patients recruited to large,
equivalent estimate of 0·78 (0·72–0·84) after clinical well designed, multicentre studies. Advances in
screening.48,140 three-dimensional imaging modalities might enable better
However, with one notable exception,69 ultrasound characterisation of hips according to variables such as
screening programmes are associated with 40–70 fold femoral anteversion. However, such techniques will need
increases in abduction splinting rates relative to the to avoid use of ionising radiation to assess normative
prevalence of developmental dysplasia of the hip before changes related to childhood growth and development.
screening was introduced.11,148 The long-term outcome for Will there be a trial of primary screening? Although
those who are treated for a disorder they do not have is an various trial designs have been proposed,4,5,24,158 they might
important consideration, since iatrogenic avascular not be feasible in countries where clinical and ultrasound
necrosis of the femoral head affects up to 1% of treated screening are already established. Medicolegal concerns,
children, might affect normal hips as well as those that combined with widely held beliefs about the effectiveness
are initially abnormal, and, in its severest form, might of screening and treatments, probably preclude the
lead to premature osteoarthritis.108,157 Other adverse equipoise needed for a trial. Introduction of a screening
consequences of abduction splinting include femoral service in a stepped-wedge design has been suggested, but
nerve palsies and pressure sores, difficulties in handling good information systems will be needed if such ecological
and positioning the infant in an abduction splinting comparisons are to link longer-term outcomes to screening
device, and parental anxiety.143,158 arm at birth.
Trials that entail random assignment to treatment with 18 Bialik V, Fishman J, Katzir J, Zeltzer M. Clinical assessment of hip
abduction splinting or watchful waiting for infants in the instability in the newborn by an orthopedic surgeon and a
pediatrician. J Pediatr Orthop 1986; 6: 703–05.
borderline ultrasound categories might prove acceptable 19 El-Shazly M, Trainor B, Kernohan WG, et al. Reliability of the
and might not only provide useful information about the Barlow and Ortolani tests for neonatal hip instability. J Med Scr
natural history of these appearances, but also help to 1994; 1: 165–68.
20 Moore FH. Examining infants’ hips–can it do harm?
assess the effectiveness and disadvantages of treatment.29,162 J Bone Joint Surg 1989; 71-B: 4–5.
In the meantime, we suggest that extension of clinical 21 Jones DA. Neonatal hip stability and the Barlow test.
screening to include universal ultrasound is not justified J Bone Joint Surg 1991; 73-B: 216–18.
scientifically or ethically—a position endorsed earlier this 22 Chow YW, Turner I, Kernohan WG, Mollan RA. Measurement of
the forces and movements involved in neonatal hip testing.
year by the US Preventive Services Task Force.162,163 Med Eng Phys 1994; 16: 181–87.
Contributors 23 Andersson JE. Neonatal hip instability: normal values for
Both authors searched the literature. C Dezateux wrote the first draft, and physiological movement of the femoral head determined by an
K Rosendahl contributed to this draft and prepared the tables and figures. anterior-dynamic ultrasound method. J Pediatr Orthop 1995; 15:
Both authors revised the manuscript and agreed and approved the final 736–40.
version. 24 Leck I. Congenital dislocation of the hip. In: Wald N, Leck I, eds.
Antenatal and neonatal screening. 2nd edn. Oxford: Oxford
Conflict of interest statement University Press, 2000: 398–424.
We declare that we have no conflict of interest. 25 Krikler SJ, Dwyer NSP. Comparison of results of two approaches
to hip screening in infants. J Bone Joint Surg 1992; 74-B: 701–03.
References
1 Dezateux C, Brown J, Arthur R, Karnon J, Parnaby A. Performance, 26 Fiddian NJ, Gardiner JC. Screening for congenital dislocation of
treatment pathways, and effects of alternative policy options for the hip by physiotherapists. Results of a ten year study.
screening for developmental dysplasia of the hip in the United J Bone Joint Surg 1994; 76-B: 458–59.
Kingdom. Arch Dis Child 2003; 88: 753–59. 27 Lee TW, Skelton RE, Skene C. Routine neonatal examination:
2 Patel H. Preventive health care, 2001 update: screening and effectiveness of trainee paediatrician compared with advanced
management of developmental dysplasia of the hip in newborns. neonatal nurse practitioner. Arch Dis Child Fetal Neonatal Ed 2001;
Can Med Assoc J 2001; 164: 1669–77. 85: 100–04.
3 Lehmann HP, Hinton R, Morello P, Santoli J. Developmental 28 Hansson G, Romanus B, Scheller S. Pitfalls of early diagnosis and
dysplasia of the hip practice guideline: technical report. Pediatrics treatment of congenital dislocation of the hip joint.
2000; 105: 57. Arch Orthop Trauma Surg 1988; 107: 129–35.
4 Shipman SA, Helfand M, Moyer VA, Yawn BP. Screening for 29 Brown J, Dezateux C, Karnon J, Parnaby A, Arthur R. Efficiency of
developmental dysplasia of the hip: a systematic literature review for alternative policy options for screening for developmental
the US Preventive Services Task Force. Pediatrics 2006; 117: 557–76. dysplasia of the hip in the United Kingdom. Arch Dis Child 2003;
88: 760–66.
5 Woolacott N, Puhan MA, Misso K, Steurer J, Kleijnen J. Systematic
review of the clinical and cost effectiveness of ultrasound in 30 Dezateux C, Godward S. Screening for congenital dislocation of
screening for developmental dysplasia of the hip in newborns. York: the hip in the newborn and young infants. In: David TJ, ed. Recent
Centre for reviews and dissemination, University of York, 2005. advances in paediatrics. 16 edn. Edinburgh: Churchill Livingstone,
1998: 41–58.
6 Furnes O, Lie SA, Espehaug B, Vollset SE, Engesaeter LB,
Havelin LI. Hip disease and the prognosis of total hip replacements. 31 Ackermann HJ, Hoferichter U. [Follow up studies on inhibited hip
A review of 53,698 primary total hip replacements reported to the joint abduction in the newborn]. Beitr Orthop Traumatol 1979; 26:
Norwegian Arthroplasty Register 1987–99. J Bone Joint Surg Br 2000; 693–98.
83: 579–86. 32 Heitner H, Jaster D, Bartolomaeus R. [Diagnosis of the dislocated
7 Aronsson DD, Goldberg MJ, Kling TF, Roy DR. Developmental hip in newborn infants]. Beitr Orthop Traumatol 1977; 24: 543–49.
dysplasia of the hip. Pediatrics 1994; 94: 201–08. 33 Jari S, Paton RW, Srinivasan MS. Unilateral limitation of
8 David TJ, Parris MR, Poynor MU, et al. Reasons for late detection of abduction of the hip. A valuable clinical sign for DDH?
hip dislocation in childhood. Lancet 1983; 2: 147–49. J Bone Joint Surg Br 2002; 84: 104–07.
9 Feldman DS. How to avoid missing congenital dislocation of the 34 Kane TP, Harvey JR, Richards RH, Burby NG, Clarke NM.
hip. Lancet 1999; 354: 1490–91. Radiological outcome of innocent infant hip clicks.
J Pediatr Orthop 2003; 12: 259–63.
10 Murray KA, Crim JR. Radiographic imaging for treatment and
follow-up of developmental dysplasia of the hip. 35 Kamath S, Bramley D. Is ‘clicky hip’ a risk factor in developmental
Semin Ultrasound CT MR 2001; 22: 306–40. dysplasia of the hip? Scott Med J 2005; 50: 56–58.
11 Rosendahl K, Markestad T, Lie RT. Ultrasound screening for 36 MacKenzie IG, Wilson JG. Problems encountered in the early
developmental dysplasia of the hip in the neonate: the effect on diagnosis and management of congenital dislocation of the hip.
treatment rate and prevalence of late cases. Pediatrics 1994; 94: 47–52. J Bone Joint Surg 1981; 63-B: 38–42.
12 Juttmann RE, de Koning HJ, Meulmeester JF, van der Maas PJ. 37 von Rosen S. Diagnosis and treatment of congenital dislocation of
[Published effects of screening in parental and child health care] the hip joint in the new-born. J Bone Joint Surg 1962; 44-B: 284–91.
Gepubliceerde effecten van screening in de ouder- en kindzorg. 38 MacKenzie IG. Congenital dislocation of the hip. J Bone Joint Surg
Ned Tijdschr Geneeskd 1996; 140: 1303–07. 1972; 54-B: 18–39.
13 Roser W. Uber angeborene Huftverrenkung. Langenbecks Arch 39 Wilkinson JA. Congenital displacement of the hip joint. Berlin :
Klin Chir 1879; 24: 309–13. Springer-Verlag, 1985.
14 Le Damany P, Saiget J. Hanches subluxables et hanches luxees chez 40 Ryder CT, Mellin WG, Caffey J. The infant’s hip–normal or
les nouveau-nes. Rev Chir Orthop 1910; 42: 512–36. dysplastic? Clin Orthop 1962; 22: 7–19.
15 Ortolani M. Un segno poco noto e sua importanza per la diagnosi 41 Kamath SU, Bennet GC. Does developmental dysplasia of the hip
precoce di prelussazione congenita dell’anca. Pediatria (Napoli) 1937; cause a delay in walking? J Pediatr Orthop 2004; 24: 265.
45: 129–36. 42 Weinstein SL. Natural history of congenital hip dislocation (CDH)
16 Palmen K. Preluxation of the hip joint. Diagnosis and treatment in and hip dysplasia. Clin Orthop 1987; 225: 62–76.
the newborn and the diagnosis of congenital dislocation of the hip 43 Graf R. The diagnosis of congenital hip-joint dislocation by the
joint in Sweden during the years 1948–1960. Acta Paediatrica (Upps) ultrasonic Combound treatment. Arch Orthop Trauma Surg 1980;
1961; 50 (suppl): 1–71. 97: 117–33.
17 Barlow TG. Early diagnosis and treatment of congenital dislocation 44 Graf R, Wilson B. Sonography of the infant hip and its therapeutic
of the hip. J Bone Joint Surg 1962; 44-B: 292–301. implications. Weinheim, Germany: Chapman and Hall; 1995.
45 Harcke HT, Clarke NM, Lee MS, Borns PF, MacEwen GD. 71 Holen KJ, Tegnander A, Bredland T, et al. Universal or selective
Examination of the infant hip with real-time ultrasonography. screening of the neonatal hip using ultrasound? A prospective,
J Ultrasound Med 1984; 3: 131–37. randomised trial of 15,529 newborn infants. J Bone Joint Surg 2002;
46 Morin C, Harcke HT, MacEwen GD. The infant hip: real time US 84: 886–90.
assessment of acetabular development. Radiology 1985; 157: 673–77. 72 Rosendahl K. The effect of ultrasound screening on late
47 Grill F, Muller D. [Results of hip ultrasonographic screening in developmental dysplasia of the hip. Arch Pediatr Adolesc Med 1995;
Austria]. Orthopade 1997; 26: 25–32. 149: 706–07.
48 Von Kries R, Ihme N, Oberle D, et al. Effect of ultrasound 73 Langer R. Ultrasonic investigation of the hip in newborns in the
screening on the rate of first operative procedures for diagnosis of congenital hip dislocation: classification and results of a
developmental hip dysplasia in Germany. Lancet 2003; 362: screening program. Skeletal Radiol 1987; 16 (4): 275–79.
1883–87. 74 Tonnis D, Storch K, Ulbrich H. Results of newborn screening for
49 Kohler G, Hell AK. Experiences in diagnosis and treatment of hip CDH with and without sonography and correlation of risk factors.
dislocation and dysplasia in populations screened by the ultrasound J Pediatr Orthop 1990; 10: 145–52.
method of Graf. Swiss Med Wkly 2003 ; 133: 484–87. 75 De Pellegrin M. Ultrasound screening for congenital dislocation of
50 Falliner A, Hahne HJ, Hassenpflug J. Sonographic hip screening the hip. Results and correlations between clinical and ultrasound
and early management of developmental dysplasia of the hip. findings. Ital J Orthop Traumatol 1991; 17: 547–53.
J Pediatr Orthop 1999; 8: 112–17. 76 Graf R, Tschauner C, Steindl M. [Does the IIa hip need treatment?
51 Riboni G, Bellini A, Serantoni S, Rognoni E, Bisanti L. Ultrasound Results of a longitudinal study of sonographically controlled hips of
screening for developmental dysplasia of the hip. Pediatr Radiol infants less than 3 months of age]. Monatsschr Kinderheilkd 1987; 135:
2003; 33: 475–81. 832–37.
52 Rosendahl K, Markestad T, Lie RT. Ultrasound in the early 77 Knapp-Birzle P. Der einfluss der sonographie auf diagnose, therapie
diagnosis of congenital dislocation of the hip: the significance of und verlauf der angeborenen huftdysplasie and huftluxation.
hip stability versus acetabular morphology. Pediatr Radiol 1992; 22: [dissertation]. Munich: Munchen Univ; 1989.
430–33. 78 Schmitz A, Wagner UA, Schmitt O. [Treatment of borderline D/IIIa
53 Novick G, Ghelman B, Schneider M. Sonography of the neonatal hip in newborn infants with the Graf-Mittelmeier abduction harness
and infant hip. AJR Am J Roentgenol 1983; 141: 639–45. under close ultrasound control]. Z Orthop Ihre Grenzgeb 1999; 137:
54 Holen KJ, Terjesen T, Tegnander A, Bredland T, Saether OD, 400–02.
Eik-Nes SH. Ultrasound screening for hip dysplasia in newborns. 79 Wood MK, Conboy V, Benson MK. Does early treatment by abduction
J Pediatr Orthop 1994; 14: 667–73. splintage improve the development of dysplastic but stable neonatal
55 Terjesen T, Bredland T, Berg V. Ultrasound for hip assessment in hips? J Pediatr Orthop 2000; 20: 302–05.
the newborn. J Bone Joint Surg 1989; 71-B: 767–73. 80 Harcke HT, Lee MS, Sinning L, Clarke NM, Borns PF, MacEwen GD.
56 Berman L, Klenerman L. Ultrasound screening for hip Ossification center of the infant hip: sonographic and radiographic
abnormalities: preliminary findings in 1001 neonates. BMJ 1986; correlation. AJR Am J Roentgenol 1986; 147: 317–21.
293: 719–22. 81 Garvey M, Donoghue VB, Gorman WA, O’Brien N, Murphy JFA.
57 Exner GU. Ultrasound screening for hip dysplasia in neonates. Radiographic screening at four months of infants at risk for
J Pediatr Orthop 1988; 8: 656–60. congenital hip dislocation. J Bone Joint Surg 1992; 74-B: 704–07.
58 Ganger R, Grill F, Leodolter S. Ultrasound screening of the hip in 82 Bone CM, Hsieh GH. The risk of carcinogenesis from radiographs to
newborns. J Pediatr Orthop 1992; 1: 45–49. pediatric orthopaedic patients. J Pediatr Orthop 2000; 20: 251–54.
59 Rosendahl K, Markestad T, Lie RT. Developmental dysplasia of the 83 Kleinberg S, Lieberman HS. The acetabular index in infants in
hip. A population-based comparison of ultrasound and clinical relation to congenital dislocation of the hip. Arch Surg 1936; 32:
findings. Acta Paediatr 1996; 85: 64–69. 1049–54.
60 Baronciani D, Atti G, Andiloro F, et al. Screening for developmental 84 Tonnis D. Congenital dysplasia and dislocation of the hip in children
dysplasia of the hip: from theory to practice. Pediatrics 1997; 99: E5. and adults. Berlin: Springer-Verlag, 1987.
61 Marks DS, Clegg J, Al-Chalabi AN. Routine ultrasound screening 85 Tonnis D, Brunken D. [Differentiation of normal and pathological
for neonatal hip instability. J Bone Joint Surg 1994; 76-B: 534–38. acetabular roof angle in the diagnosis of hip dysplasia. Evaluation of
2294 acetabular roof angles of hip joints in children].
62 Andersson J, Funnemark P-O. Neonatal hip instability: screening
Arch Orthop Unfallchir 1968; 64: 197–228.
with anterior-dynamic ultrasound method. J Pediatr Orthop 1995; 15:
322–24. 86 Boniforti FG, Fujii G, Angliss RD, Benson MK. The reliability of
measurements of pelvic radiographs in infants. J Bone Joint Surg 1997;
63 Zieger M. Ultrasound of the infant hip. Part 2: validity of the
79: 570–75.
method. Pediatr Radiol 1986; 16: 488–92.
87 Severin E. Congenital dislocation of the hip joint. Late results of
64 Roovers EA, Boere-Boonekamp MM, Geertsma TS, Zielhuis GA,
closed reduction and arthrographic studies of recent cases.
Kerkhoff AH. Ultrasonographic screening for developmental
Acta Chirurgica Scandinavica 1941; 74: 7–142.
dysplasia of the hip in infants. Reproducibility of assessments made
by radiographers. J Bone Joint Surg 2003; 85: 726–30. 88 Dunn PM. Congenital dislocation of the hip (CDH): necropsy studies
at birth. Proc R Soc Med 1969; 62: 1035–37.
65 Rosendahl K, Aslaksen A, Lie RT, Markestad T. Reliability of
ultrasound in the early diagnosis of developmental dysplasia of the 89 Dunn PM. Perinatal observations on the etiology of congenital
hip. Pediatr Radiol 1995; 25: 219–24. dislocation of the hip. Clin Orthop 1976; 119: 11–22.
66 Dias JJ, Thomas IH, Lamont AC, Mody BS, Thompson JR. The 90 Terjesen T, Runden TO, Tangerud A. Ultrasonography and radio-
reliability of ultrasonographic assessment of neonatal hips. graphy of the hip in infants Acta Orthop Scand 1989; 60 (6): 651–60.
J Bone Joint Surg 1993; 75-B: 479–82. 91 Somerville EW. A long-term follow up of congenital dislocation of the
67 Bar-On E, Meyer S, Harari G, Porat S. Ultrasonography of the hip in hip. J Bone Joint Surg 1978; 60-B: 25–30.
developmental hip dysplasia. J Bone Joint Surg 1998; 80: 321–24. 92 Wedge JH, Wasylenko MJ. The natural history of congenital
68 Simon EA, Saur F, Buerge M, Glaab R, Roos M, Kohler G. dislocation of the hip: a critical review. Clin Orthop 1978; 137: 154–62.
Inter-observer agreement of ultrasonographic measurement of 93 Gibson PH, Benson MKD. Congenital dislocation of the hip: review
alpha and beta angles and the final type classification based on the at maturity of 147 hips treated by excision of the limbus and
Graf method. Swiss Med Wkly 2004 ; 134: 671–77. derotation osteotomy. J Bone Joint Surg 1982; 64-B: 169–75.
69 Marks DS, Clegg J, Al-Chalabi AN. Routine ultrasound screening 94 Smith WS, Badgley CE, Orwig JB, Harper JM, Arbor A. Correlation of
for neonatal hip instability. Can it abolish late-presenting congenital postreduction roentgenograms and thirty-one-year follow-up in
dislocation of the hip? J Bone Joint Surg 1994; 76: 534–38. congenital dislocation of the hip. J Bone Joint Surg Am 1968; 50:
70 Roovers EA, Boere-Boonekamp MM, Mostert AK, Castelein RM, 1081–98.
Zielhuis GA, Kerkhoff TH. The natural history of developmental 95 Angliss R, Fujii G, Pickvance E, Wainwright AM, Benson MK.
dysplasia of the hip: sonographic findings in infants of 1–3 months Surgical treatment of late developmental displacement of the hip.
of age. J Pediatr Orthop 2005; 14: 325–30. Results after 33 years. J Bone Joint Surg 2005; 87: 384–94.
96 Malvitz TA, Weinstein SL. Closed reduction for congenital dysplasia 120 Yoshimura N, Campbell L, Hashimoto T, et al. Acetabular dysplasia
of the hip. Functional and radiographic results after an average of and hip osteoarthritis in Britain and Japan. Br J Rheumatol 1998; 37:
thirty years. J Bone Joint Surg Am 1994; 76: 1777–92. 1193–97.
97 Ali AM, Angliss R, Fujii G, Smith DM, Benson MK. Reliability of the 121 Muller GM, Seddon HJ. Late results of treatment of congenital
Severin classification in the assessment of developmental dysplasia dislocation of the hip. J Bone Joint Surg 1953; 35-B: 342–62.
of the hip. J Pediatr Orthop 2001; 10: 293–97. 122 Weinstein SL. Natural history and treatment outcomes of childhood
98 Ward WT, Vogt M, Grudziak JS, Tumer Y, Cook PC, Fitch RD. hip disorders. Clin Orthop Relat Res 1997; 344: 227–42.
Severin classification system for evaluation of the results of operative 123 Wedge JH, Wasylenko MJ. The natural history of congenital disease
treatment of congenital dislocation of the hip. A study of of the hip. J Bone Joint Surg 1979; 61-B: 334–38.
intraobserver and interobserver reliability. J Bone Joint Surg 1997; 79: 124 Hartofilakidis G, Karachalios T, Stamos KG. Epidemiology,
656–63. demographics, and natural history of congenital hip disease in
99 Crowe JF, Mani VJ, Ranawat CS. Total hip replacement in congenital adults. Orthopedics 2000; 23: 823–27.
dislocation and dysplasia of the hip. J Bone Joint Surg 1979; 61: 15–23. 125 Wald NJ, Terzian E, Vickers PA. Congenital talipes and hip
100 Hartofilakidis G, Stamos K, Ioannidis TT. Low friction arthroplasty malformation in relation to amniocentesis: a case-control study.
for old untreated congenital dislocation of the hip. J Bone Joint Surg Lancet 1983; 2: 246–49.
1988; 70: 182–86. 126 Lapunzina P, Camelo JS, Rittler M, Castilla EE. Risks of congenital
101 Cameron HU, Botsford DJ, Park YS. Influence of the Crowe rating anomalies in large for gestational age infants. J Pediatr 2002; 140:
on the outcome of total hip arthroplasty in congenital hip dysplasia. 200–04.
J Arthroplasty 1996; 11: 582–87. 127 Salter RB. Etiology, pathogenesis and possible prevention of
102 Decking R, Brunner A, Decking J, Puhl W, Gunther KP. Reliability of congenital dislocation ot the hip. Can Med Assoc J 1968; 98: 933–45.
the Crowe und Hartofilakidis classifications used in the assessment 128 Forst J, Forst C, Forst R, Heller KD. Pathogenetic relevance of the
of the adult dysplastic hip. Skeletal Radiol 2006; 35: 282–87. pregnancy hormone relaxin to inborn hip instability.
103 Weinstein SL. Traction in developmental dislocation of the hip. Is its Arch Orthop Trauma Surg 1997; 116: 209–12.
use justified? Clin Orthop Relat Res 1997; 338: 79–85. 129 Vogel I, Andersson JE, Uldbjerg N. Serum relaxin in the newborn is
104 Editorial. Epiphysitis in congenital dislocation of the hip. BMJ 1981; not a marker of neonatal hip instability. J Pediatr Orthop 1998; 18:
282: 926–27. 535–37.
105 Kalamchi A, MacEwen GD. Avascular necrosis following treatment 130 Andersson JE, Vogel I, Uldbjerg N. Serum 17 beta-estradiol in
of congenital dislocation of the hip. J Bone Joint Surg 1980; 62-A: newborn and neonatal hip instability. J Pediatr Orthop 2002; 22:
876–88. 88–91.
106 Omeroglu H, Tumer Y, Bicimoglu A, Agus H. Intraobserver and 131 Thieme WT, Wynne-Davies R. Clinical examination and urinary
interobserver reliability of Kalamchi and Macewen’s classification oestrogen assays in newborn children with congenital dislocation of
system for evaluation of avascular necrosis of the femoral head in the hip. J Bone Joint Surg 1968; 50-B: 546–50.
developmental hip dysplasia. Bull Hosp Jt Dis 1999; 58: 194–96. 132 Wynne Davies R. Acetabular dysplasia and familial joint laxity: two
107 Zadeh HG, Catterall A, Hashemi-Nejad A, Perry RE. Test of stability etiological factors in congenital dislocation of the hip.
as an aid to decide the need for osteotomy in association with open J Bone Joint Surg 1970; 52-B: 704–16.
reduction in developmental dysplasia of the hip. J Bone Joint Surg 133 Paton RW, Hinduja K, Thomas CD. The significance of at-risk
2000; 82: 17–27. factors in ultrasound surveillance of developmental dysplasia of the
108 Shipman S, Helfand M, Nygren P, Bougatsos C. Screening for hip. A ten-year prospective study. J Bone Joint Surg 2005; 87-B:
developmental dysplasia of the hip: systematic evidence synthesis. 1264–66.
Rockville, MD: Agency for Health Care Research and Quality, US 134 Kramer AA, Berg K, Nance WE. Familial aggregation of congenital
Department of Health and Human Services, 2006. dislocation of the hip in a Norwegian population. J Clin Epidemiol
109 Weinstein SL. Bristol-Myers Squibb/Zimmer award for 1988; 41: 91–96.
distinguished achievement in orthopaedic research. Long-term 135 Hakim AJ, Cherkas LF, Grahame R, Spector TD, MacGregor AJ.
follow-up of pediatric orthopaedic conditions. Natural history and The genetic epidemiology of joint hypermobility: a population study
outcomes of treatment. J Bone Joint Surg 2000; 82-A: 980–90. of female twins. Arthritis Rheum 2004; 50: 2640–44.
110 Albinana J, Dolan LA, Spratt KF, Morcuende J, Meyer MD, 136 Granchi D, Stea S, Sudanese A, Toni A, Baldini N, Giunti A.
Weinstein SL. Acetabular dysplasia after treatment for developmental Association of two gene polymorphisms with osteoarthritis
dysplasia of the hip. Implications for secondary procedures. secondary to hip dysplasia. Clin Orthop Relat Res 2002; 403: 108–17.
J Bone Joint Surg 2004; 86: 876–86.
137 Jordan JM, Kraus VB, Hochberg MC. Genetics of osteoarthritis.
111 Gent E, Clarke NM. Joint replacement for sequelae of childhood hip Curr Rheumatol Rep 2004; 6: 7–13.
disorders. J Pediatr Orthop 2004; 24: 235–40.
138 Dezateux C, Godward S. A national survey of screening for
112 Harcke HT. Imaging methods used for children with hip dysplasia. congenital dislocation of the hip. Arch Dis Child 1996; 74: 445–48.
Clin Orthop Relat Res 2005; 434: 71–77.
139 Elbourne D, Dezateux C, Arthur R, et al. Ultrasonography in the
113 Sugano N, Noble PC, Kamaric E, Salama JK, Ochi T, Tullos HS. The diagnosis and management of developmental hip dysplasia (UK
morphology of the femur in developmental dysplasia of the hip. Hip Trial): clinical and economic results of a multicentre
J Bone Joint Surg 1998; 80-B: 711–19. randomised controlled trial. Lancet 2002; 360: 2009–17.
114 Visser JD, Jonkers A. A method for calculating acetabular 140 Godward S, Dezateux C. Surgery for congenital dislocation of the
anteversion, femur anteversion and the instability index of the hip hip in the UK as a measure of outcome of screening. Lancet 1998;
joint. Neth J Surg 1980; 32: 146–49. 351: 1149–52.
115 Hernandez RJ, Poznanski AK. CT evaluation of pediatric hip 141 Cashman JP, Round J, Taylor G, Clarke NM. The natural history of
disorders. Orthop Clin North Am 1985; 16: 513–41. developmental dysplasia of the hip after early supervised treatment
116 Chan A, McCaul KA, Cundy PJ, Haan EA, Byron Scott R. Perinatal in the Pavlik harness. A prospective, longitudinal follow-up.
risk factors for developmental dysplasia of the hip. Arch Dis Child J Bone Joint Surg 2002; 84-B: 418–25.
1997; 76: F94–100. 142 McHale KA, Corbett D. Parental noncompliance with Pavlik
117 Rabin DL, Barnett CR, Arnold WD, Freiberger RH, Brooks G. harness treatment of infantile hip problems. J Pediatr Orthop 1989;
Untreated congenital hip disease. A study of the epidemiology, 9: 649–52.
natural history and social aspects of the disease in a Navajo 143 Gardner F, Dezateux C, Elbourne D, Gray A, King A, Quinn A. The
population. Am J Public Health 1965; 55 (suppl 28): 1–44. hip trial: psychosocial consequences for mothers of using
118 Yamamuro T, Ishida K. Recent advances in the prevention, early ultrasound to manage infants with developmental hip dysplasia.
diagnosis, and treatment of congenital dislocation of the hip in Arch Dis Child Fetal Neonatal Ed 2005; 90: 17–24.
Japan. Clin Orthop 1983; 184: 34–40. 144 Taylor GR, Clarke NM. Monitoring the treatment of developmental
119 Kutlu A, Memik R, Mutlu M, Kutlu R, Arslan A. Congenital dysplasia of the hip with the Pavlik harness. The role of ultrasound.
dislocation of the hip and its relation to swaddling used in Turkey. J Bone Joint Surg 1997; 79-B: 719–23.
J Pediatr Orthop 1992; 12: 598–602.
145 Coleman SS. Developmental dislocation of the hip: evolutionary 155 Williamson J. Difficulties of early diagnosis and treatment of
changes in diagnosis and treatment. J Pediatr Orthop 1994; 14: 1–2. congenital dislocation of the hip in Northern Ireland.
146 Williamson DA, Glover SD, Benson MKD. Congenital dislocation of J Bone Joint Surg 1972; 54-B: 13–17.
the hip presenting after the age of three years. J Bone Joint Surg 156 Chan A, Cundy PJ, Foster BK, Keane RJ, Byron-Scott R. Late
1989; 71-B: 745–51. diagnosis of congenital dislocation of the hip and presence of a
147 Graf R, Tschauner C, Klapsch W. Progress in prevention of late screening programme: South Australian population-based study.
developmental dislocation of the hip by sonographic newborn hip Lancet 1999; 354: 1514–17.
“screening”: results of a comparative follow-up study. 157 Gore DR. Iatrogenic avascular necrosis of the hip in young children:
J Pediatr Orthop 1993; 2: 115–21. a long-term follow-up. J Pediatr Orthop 1999; 19: 635–40.
148 Altenhofen L, Allhoff PG, Niethard FU. [Hip ultrasound screening 158 Dezateux C, Godward S. Evaluating the national screening
within the scope of U3—initial experiences]. Z Orthop Ihre Grenzgeb programme for congenital dislocation of the hip. J Med Scr 1995; 2:
1998; 136: 501–07. 200–06.
149 Jones DA, Powell N. Ultrasound and neonatal hip screening. A 159 Gray A, Elbourne D, Dezateux C, King A, Quinn A, Gardner F.
prospective study of ‘high risk’ babies. J Bone Joint Surg 1990; 72-B: Economic evaluation of ultrasonography in the diagnosis and
457–59. management of developmental hip dysplasia in the United
150 Clarke NMP, Clegg J, Al-Chalabi AN. Ultrasound screening of hips Kingdom and Ireland. J Bone Joint Surg 2005; 87: 2472–79.
at high risk for CDH: failure to reduce the incidence of late cases. 160 Roberton NR. Screening for congenital hip dislocation. Lancet 1984;
J Bone Joint Surg 1989; 71-B: 9–12. 1: 909–10.
151 Sochart DH, Paton RW. Role of ultrasound assessment and harness 161 Elliman DA, Dezateux C, Bedford HE. Newborn and childhood
treatment in the management of developmental dysplasia of the screening programmes: criteria, evidence, and current policy.
hip. Ann R Coll Surg Engl 1996; 78: 505–08. Arch Dis Child 2002; 87: 6–9.
152 Jones D, Dezateux CA, Danielsson LG, Paton RW, Clegg J. At the 162 Elbourne D, Dezateux C. Hip dysplasia and ultrasound imaging of
crossroads—neonatal detection of developmental dysplasia of the whole populations: the precautionary principle revisited.
hip. J Bone Joint Surg 2000; 82-B: 160–64. Arch Dis Child Fetal Neonatal Ed 2005; 90: 2–3.
153 Lennox IAC, McLauchlan J, Murali R. Failures of screening and 163 Screening for developmental dysplasia of the hip: recommendation
management of congenital dislocation of the hip. J Bone Joint Surg statement. Pediatrics 2006; 117: 898–902.
1993; 75-B: 72–75.
154 Catford JC, Bennet GC, Wilkinson JA. Congenital hip dislocation:
an increasing and still uncontrolled disability? BMJ 1982; 285:
1527–30.