# Research Title Author Year Abstract Classification Randomizati

Published Study Design Outcome Hypothesis on Procedure

Classification Classification Used
6 A pilot study to Nikolaizik WH, 2008 Jul-Aug BACKGROUND: Crossover Explanatory With reference Simple
compare Vietzke D, Ratjen F. Inhaled tobramycin has been shown to improve trial
tobramycin 80 mg lung function in cystic fibrosis (CF) patients
injectable chronically infected with Pseudomonas
preparation with aeruginosa. However, to date no comparative
300 mg solution for data are available for different dose regimens
inhalation in cystic used in clinical practice.
fibrosis patients
OBJECTIVES:
To compare the clinical efficacy of the two most
commonly used treatment regimens of inhaled
tobramycin in patients with CF.
METHODS:
In an open crossover study of CF patients,
subjects were randomly allocated to receive
either 80 mg tobramycin twice-daily continuous
treatment or 300 mg tobramycin twice daily in
cycles of 28 days on and 28 days off treatment.
After three months, patients were switched to
the alternative treatment regimen.
RESULTS:
A total of 32 patients with a mean (+/- SD) age
of 18.5+/-8.6 years were included in the study.
Compared with the treatment period using
colistin, forced expiratory volume in 1 s
decreased by -2.1+/-13.8% in the 80 mg
tobramycin group and increased by +2.3+/-
13.0% in the 300 mg group. Similar changes
were observed in forced vital capacity (-2.5+/-
12.9% in the 80 mg tobramycin group versus
 +2.5+/-9.6% in the 300 mg tobramycin group).
Variability in responses was large but the
differences were not statistically significant.
Personal preference indicated that the majority
of patients preferred the high-dose cycle
compared with the lower dose continuous
inhalation, but this was not linked to objective
data on efficacy.
CONCLUSIONS:
The present trial fails to provide convincing
evidence for superiority in efficacy of either of
the two treatment regimens of inhaled
tobramycin in CF patients

7 Atorvastatin Mukherjee S, 2008 Nov Increased arterial stiffness is an independent predictor of Parallel Group Explanatory Superiority Simple
improves arterial Mukhopadhyay P, cardiovascular disease and mortality in middle-aged and
stiffness in Pandit K, olderadults. We measured arterial stiffness by pulse wave
velocity (PWV)in brachial-ankle segments by automated
normotensive Mukherjee S, oscillometry in 71 normotensive and normolipidaemic
normolipidaemic Chowdhury S. subjects with type 2 diabetes (40 males and 31 females).
persons with type 2 57 patients (whose baPWV was more than 1400
diabetes cm/second) were randomised into two groups, group A
(n=29) were given 10 mg atorvastatin daily for 6 months
and group B (n=28) were given placebo. After 6 months,
atorvastatin group had significant improvement in brachial-
ankle pulse wave velocity (baPWV) (1712.03 +/- 349.9
cm/second versus 1558.81 +/- 303.26 cm/ second, p<
0.05). Though the placebo group showed some
improvement (1692.03 +/- 425.15 cm/second versus
1636.78 +/- 425.1 cm/second) it was not statistically
significant. Despite correlation was noted between baPWV
and systolic blood pressure (SBP), there was no significant
correlation between the mean baPWV and duration of
diabetes, body mass index (BMI), waist circumference,
waist-hip ratio (WHR), waist to height ratio (WHtR),
glycated haemoglobin (HbA1c), LDL, HDL cholesterol and
 spot urine albumin creatinine ratio (ACR) at the baseline.
The decrement of LDL-cholesterol is correlated with the
decrement of the baPWV in the atorvastatin group only
(p<0.01).
8 Effectivity of Aysan E, Sevinc M, 2008 Nov-Dec BACKGROUND: Parallel- Pragmatic Equivalence Urn
qualitative urinary Basak E, Tardu A, There is no any definite diagnostic test for Group
trypsinogen-2 Erturk T. acute pancreatitis. In the present study we
measurement in the investigated the value of the qualitative urinary
diagnosis of acute trypsinogen-2 measurement in the diagnosis of
pancreatitis: a acute pancreatitis by an immuno-
randomized, clinical chromatographic dipstick test.
study
METHODS:
A prospective, randomized, clinical trial was
planned on 99 patients (53 male, 46 female;
male/female : 1.11; age range: 16-83; mean
age: 37.4). Patients were divided into two
groups: 50 cases were referred to our
emergency surgical unit due to abdominal pain
and diagnosed with acute pancreatitis by
abdominal computerized tomography (CT)
(Group 1); 49 cases were referred to our
emergency surgical unit due to abdominal pain
and whose abdominal CTs did not show any
sign of acute pancreatitis (Group 2). Qualitative
urinary trypsinogen-2 measurement, abdominal
CT and blood amylase values were obtained in
all cases.
RESULTS:
In group 1, urinary trypsinogen-2 measurement
was found positive in 28 cases out of 50 cases
diagnosed with acute pancreatitis (56%
sensitivity). In group 2, results were found
positive in 3 out of 49 patients with abdominal
 pain, who lacked an acute pancreatitis
diagnosis (90.9% specificity). Severe intra-
abdominal inflammation was present in three
cases of group 2 where we obtained false
positive results which may stimulate the
pancreatic exocrine secretion.
CONCLUSION:
Qualitative measurements of urinary
trypsinogen-2 in patients with abdominal pain
may be useful in the diagnosis of acute
pancreatitis. It is an easy, inexpensive, rapid
and noninvasive method.

9 Dual blockade of the Tylicki L, Renke M, 2008 OBJECTIVE: Parallel-Group Pragmatic Superiority Restrictive
renin-angiotensin- Rutkowski P, Despite the proven effectiveness of
aldosterone system Larczyński W, combination therapy with an angiotensin I-
with high-dose Aleksandrowicz E, converting enzyme inhibitor (ACEI) and
angiotensin- Lysiak-Szydlowska angiotensin II-receptor blockers (ARBs) for the
converting enzyme W, Rutkowski B. prevention and treatment of kidney disease, it
inhibitor for has not proved possible to inhibit the progress
nephroprotection: of chronic nephropathies completely. To
an open, controlled,
improve renal outcome one may consider using
randomized study
increased dosages of ACEI above those
usually recommended for hypertension.
MATERIAL AND METHODS:
A randomized, open, controlled study was
conducted to evaluate the influence of two
combination therapies on proteinuria, markers
of tubular injury and renal fibrosis. A total of 18
patients with a creatinine level of 109+/-36
micromol/l and proteinuria of 0.97+/-0.76 g/24 h
 were enrolled in the study. In the 8-week run-in
period, an ACEI (cilazapril 5 mg once-daily)
and an ARB (telmisartan 80 mg once-daily)
were administered to achieve the target blood
pressure of < or = 130/80 mmHg. Next, the
patients were randomly assigned to either an
increased dose of cilazapril (10 mg) or the
previous dose (5 mg) in two active-treatment
periods, each lasting 8 weeks.
RESULTS:
A significant increase in renin activity was
observed after administration of cilazapril 10
mg (6.46+/-1.12 vs 4.67+/-0.7 ng/ml/h;
p=0.028). Proteinuria, urine excretion of N-
acetyl-beta-D-glucosaminidase, and alpha1-
microglobulin and amino-terminal propeptide of
type III procollagen were unchanged.
CONCLUSION:
An increased dosage of cilazapril (twice the
maximum recommended dose) in addition to
combination therapy with telmisartan was
associated with increased blockade of the
renin-angiotensin-aldosterone system, with no
additional effect on proteinuria, markers of
tubular injury or renal fibrosis.

10 Effects of warm Zhao LH, Nong ZN, 2008 Dec OBJECTIVE: Parallel-Group Pragmatic Superiority Restrictive
needle moxibustion Zhong X, Pang Y, To compare therapeutic effects of warm needle
on bone mass Liang JS, Li XD, Ye moxibustion and medication on osteoporosis
density and FW. and to study the mechanism.
biochemical indexes
METHODS:
of bone metabolism
in patients of Forty cases were randomly divided into an
postmenopausal acupuncture group and a medication group, 20
osteoporosis cases in each group. The acupuncture group
was treated by warm needle moxibustion at
Dazhu (BL 11), Ganshu (BL 18), Shenshu (BL
23), Zusanli (ST 36), Yanglingquan (GB 34)
etc. once other day, for 3 months; and the
medication group was treated by oral
administration of tablet Caltrate with Vit D2 for
3 months. The changes of bone mass density
(BMD), estradiol (E2), osteocalcin (bone growth
protein, BGP), urine calcium/creatinine (Ca/Cr)
in the two groups before and after treatment
and therapeutic effects were investigated.
RESULTS:
After treatment, BMD significantly increased
(P<0.05, P<0.01) in the acupuncture group and
did not signifi cantly changed in the medication
group (P>0.05) with a significant difference
between the two groups (P<0.05). After
treatment E2 level significantly increased as
compared with before treatment in both of
groups (P<0.01); after treatment BGP
significantly decreased as compared with
before treatment in both of groups (P<0.01);
after treatment Ca/Cr significantly decreased
as compared with before treatment in the
acupuncture group (P<0.05) ; af ter treatment,
there were significant differences in BGP and
Ca/Cr between the two groups (P<0.05 or
P<0.01). The clinically controlled rate in the
acupuncture group and in the medication group
 were 35.0%, 5.0%, respectively, the
therapeutic effect of the acupuncture group
being better than that of the medication group
(P<0.01).
CONCLUSION:
The therapeutic effect of warm needle
moxibustion on osteoporosis is better than that
of oral administration of tablet Caltrate with Vit
D2 and it can increase levels of hormones and
delay bone loss. It is an effective method for
preventing and treating postmenopausal
osteoporosis.

Links:

6.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679548/

7.

https://www.ncbi.nlm.nih.gov/pubmed/19368096?fbclid=IwAR101PEjoTAs94CJr1DHXtt461O5TSOUscQ7il8h0JmZddUodkBUxcPUCLw

8.

https://www.ncbi.nlm.nih.gov/pubmed/19241920?fbclid=IwAR1oxP3HtIC2rGJc6Q_QPv9ddrJ7SBNDBJ1NfKtR0qkulWq9WZaOEcxUq9I

9.

https://www.ncbi.nlm.nih.gov/pubmed/19230172?fbclid=IwAR0U3BWO9mLkEAHJ6MMrt_AkdZ-o9m7s1uizGl5QVZLtJQAB_ibf6YEan_M
10.

https://www.ncbi.nlm.nih.gov/pubmed/19127918?fbclid=IwAR3LL16d2h3jtnOztywILdtYATrmpBkIiUP1HRf3HQFjxQ0yAZxMTPLyRI4