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TECHNICAL STRATEGY

Retrobulbar Hemorrhage During or After Endonasal or


Periorbital Surgery: What to Do, When and How to Do It
Giacomo Colletti, MD, Paolo Fogagnolo, MD,y Fabiana Allevi, MD, Dimitri Rabbiosi, MD,
Valentina Bebi, MD,z Luca Rossetti, MD,§ Matteo Chiapasco, MD,jj and Giovanni Felisati, MDz
damaged during these procedures. However, this is not the case
Abstract: Retrobulbar hemorrhage (RBH) is an uncommon com- and RBH occurs with the same incidence during or after endoscopic
plication of endoscopic sinus surgery or periorbital surgery con- surgery for nasal inflammatory diseases. Therefore, expert surgeons
sisting in an accumulation of blood within the orbit posteriorly to as well as less experienced ones would have to face RBH during
the eyeball. It must be treated within 90-100 minutes to avoid their careers.
irreversible visual loss. The present paper tries to pinpoint the key If untreated, RBH can rapidly lead to loss of vision. Many authors
steps in diagnosis and treatment of RBM. state that if RBH is treated appropriately within 90–100 minutes,
On the wake of a new case, the authors review and update their irreversible injuries are prevented. Conversely, any delay in diagnosis
or treatment of this true emergency can cause permanent visual loss.5
clinical experience and propose a step-by-step protocol to diagnose and
RBH onset determines 3 symptoms: pain, proptosis, and pro-
to treat RBH developing under different circumstances: during endo- gressive decrease of visual acuity; pain and decrease of visual acuity
scopic sinus surgery, during periorbital surgery, immediately after the might be misdiagnosed if the patient is sleeping during or after
surgery, in the awakening room, or postoperatively in the ward. surgery. Only a minority of emergency senior house officers were
A therapeutic ladder is proposed that starts with lateral canthot- able to correctly diagnose RBH according to a recent paper.6 Even
omy and inferior cantholysis and progresses to a lower lid trans- when a correct diagnosis is made, treatment is often the result of the
conjunctival incision with retrocaruncular extension. doctor’s preferences and confidence with certain techniques. Based
Based on our experience, the proposed guidelines are effective on the results of a survey, few senior house officers were able to
in diagnosing and treating RBH. They allow to preserve vision and choose and perform a correct surgical approach in case of RBH.6
minimize reliquates of this rare and dangerous surgical emergency. The mechanisms behind visual loss in RBH are poorly under-
stood, but it is clear that reduction of intraorbital pressure is the key
to recovery. However, surgical maneuvers commonly advocated to
Key Words: inferior cantholysis, lateral canthotomy, retrobulbar
achieve this such as lateral canthotomy (LC) and inferior cantho-
hemorrhage, transconjunctival access, transpalpebral management lysis (IC) can, at times, be insufficient. Also, other therapeutic
(J Craniofac Surg 2015;26: 897–901) options are available if hemorrhage is caused by arterial laceration
during endoscopic sinus surgery.
The aim of this paper is to provide protocol to manage RBH
R etrobulbar hemorrhage (RBH) is a rare entity. Accumulation of
blood posteriorly to the eye can occur as a consequence of
trauma to the orbit or the zygoma, after periorbital surgery, or after
during surgery in the OR, immediately after surgery when the
patient is in the postoperative monitoring area, and after surgery
when the patient is in the ward.
endoscopic sinus surgery (ESS) (Figs. 1, 2). The event of RBH after
periorbital soft tissue surgery is extremely rare with a reported
0.0052% in blepharoplasties.1,2 Similarly, RBH as a consequence of MATERIALS AND METHODS
ESS is an unusual eventuality with a reported frequency of 0.002 to
0.006.3,4 One could imagine that this event could happen more Surgical Technique
frequently during or after endoscopic oncological surgery in that the
lamina papyracea and the ethmoidal arteries are more likely Intraoperative Management During ESS
If an orbital hemorrhage is the result of the severing of the
anterior or posterior ethmoidal artery,7 then the surgeon will gently
From the Department of Head and Neck Surgery, Section of Maxillo
remove the papyracea and try to cauterize the vessel. However,
Facial Surgery, San Paolo Hospital, University of Milan, Milan; yG.B.
Bietti Foundation for Study and Research in Ophthalmology—IRCCS, if a RBH develops and quick resolution cannot be achieved with
Rome; zDepartment of Head and Neck Surgery, Section of Otolaryngol- this technique, an external approach must be immediately chosen
ogy, San Paolo Hospital, University of Milan, Milan; §Department of (see Results and Discussion).
Head and Neck Surgery, Section of Ophthalmology, San Paolo Hospital,
University of Milan, Milan; and jjDepartment of Health Sciences,
Division of Oral Surgery, San Paolo Hospital, University of Milan, Lateral Canthotomy
Milan, Italy. If the patient is awake, local anesthetic with 1:200,000 adrenalin
Received June 23, 2014. is injected in the lateral soft tissues of the orbit including the lateral
Accepted for publication December 2, 2014. canthus, the underlying periosteum, and the upper malar region.
Address correspondence and reprint requests to Giacomo Colletti, MD, The conjunctiva is anesthetized with topical anesthetic drops
Piazza della Repubblica 1/a, 20121 Milan, Italy; E-mail: giacomo. (oxibuprocaine 0.4%, Novesine or Benoxinate).
colletti@gmail.com The upper and lower lids are retracted with small skin hooks and
Level of Evidence: 4. Case series.
the lateral canthus is incised (Figs. 3, 4). The skin incision is
The authors report no conflicts of interest.
Copyright # 2015 by Mutaz B. Habal, MD protracted laterally and caudally for 7–8 mm. Some bleeding from
ISSN: 1049-2275 small vessels is to be expected and the latter have to be cauterized.
DOI: 10.1097/SCS.0000000000001508 The dissection then deepens to the periosteum. Here, the wound is

The Journal of Craniofacial Surgery  Volume 26, Number 3, May 2015 897
Copyright © 2015 Mutaz B. Habal, MD. Unauthorized reproduction of this article is prohibited.
Colletti et al The Journal of Craniofacial Surgery  Volume 26, Number 3, May 2015

FIGURE 3. Lateral canthotomy. Presurgical drawing. The skin incision is


planned in a preexistent crease and is 8–10 mm long.
FIGURE 1. Clinical appearance of a retrobulbar hematoma after a blunt trauma
to the right eye. The eye is pushed ventrally and caudally with an evident Retracting the wound margins, the dissection proceeds medially
proptosis. towards the medial orbital wall. Care is taken to avoid the lacrimal
sac. This is accomplished by identifying the anterior and posterior
divaricated and the incision on the canthus is extended to involve lacrimal crest. The dissection has to aim dorsally to the latter. This
3 mm of its inner face which is covered by conjunctiva. Lateral dissection has to be made almost 90 degrees to the medial orbital
canthotomy achieves only minimal inferior lid release (Fig. 5). wall to avoid injury to the extraocular muscles. The periosteum of
the medial wall is incised and elevated (Figs. 10B, C).
Inferior Cantholysis
Again, the lids are retracted with the aid of 2 small hooks. The Finding the Source of Bleeding
lateral canthal insertion can be palpated as a hard inextensible The orbital periosteum is elevated. If the cause of the bleeding
tendon bridging the lateral orbital rim and the lateral canthus. When was ESS (and the papyracea was not widely removed), it is probable
identified, this is sharply dissected (Fig. 6) and the lower lid to find a single breach in the wall and in the periosteum that allows
immediately becomes highly mobile8 (Fig. 7). Some remaining for prompt recognition of the source of bleeding. Frequently, the
fibrous connections between the tarsus and the periosteum can limit anterior ethmoidal artery is responsible for RBH development in
lower lid mobility. These are promptly severed. these cases (Fig. 11). Bipolar coagulation allows a rapid resolution
of bleeding.
When RBH is the consequence of lid surgery, then the perios-
Inferior Transconjunctival Incision With teum of the inferior wall must be incised and dissected. The
Retrocaruncular Extension hematoma will show up and it must be evacuated. The bleeding
Holding the tarsus of the inferior lid with the forceps and vessel must be carefully searched and coagulated; however, bleed-
retracting it laterally and ventrally, the conjunctiva of the inferior ing may be sometimes absent.
lid is unrolled. With small sharp-tip scissors, a blunt dissection is If RBH is traumatic or develops after orbital surgery, then the
made immediately deep to the conjunctiva caudally to the tarsus periosteum is likely already interrupted. The hematoma must be
(Fig. 8A). The dissection proceeds for 1 cm. Then the scissors are entirely evacuated and the source of bleeding meticulously
removed and rotated 90 degrees inserting 1 blade under the con- searched. In our experience, the infraorbital artery is very frequently
junctiva which is cut (Fig. 8B). This dissection goes on until the the cause of RBH after traumas.
caruncula lacrimalis is reached. At this point, the incision bends If hypotensive drugs have been administered during elective
cranially and runs 1–2 mm lateral to the caruncula until the con- surgery, then the anesthesiologist is asked to increase blood pressure
junctiva of the upper lid is reached. Again, the borders of the at levels normal for the patient. Operatory field is again carefully
incision in the lower lid are retracted with the aid of the hooks; the inspected to find out any additional source of bleeding.
inferior orbital rim is reached by blunt and sharp dissection, ventral Then a Penrose drainage is placed from the site of the hematoma
to the lower lid orbital septum. The periosteum of the rim is incised to the lateral canthus.
(Fig. 9) and elevated. If needed, the periosteum of the inferior The lateral canthus is reapproximated with one single stitch at
orbital wall is elevated. At the level of the medial one-third of the end of the operation.
the orbital rim, the origin of the small oblique muscle is found The definitive closure in layers will take place after 3–4 days.
(Fig. 10A) and elevated with the periosteal insertions.

FIGURE 2. Coronal TC of the same patient. A retrobulbar hemorrhage has FIGURE 4. Lateral canthotomy. Two skin hooks are used to retract the lids. The
caused a hematoma in the cranial part of the right orbit. canthus becomes clearly evident and is incised with a scalpel.

898 # 2015 Mutaz B. Habal, MD

Copyright © 2015 Mutaz B. Habal, MD. Unauthorized reproduction of this article is prohibited.
The Journal of Craniofacial Surgery  Volume 26, Number 3, May 2015 Retrobulbar Hemorrhage

FIGURE 5. Lateral canthotomy. Only minimal mobility is gained after the


canthotomy. The upper and lower arms of the canthus are only 4-5 mm
away from each other even if the incision has reached the periosteum.
FIGURE 7. Inferior cantholysis. Cutting the periosteal insertion of the lateral
canthus allows a high degree of mobility to the lower lid. At least 15 mm of
RESULTS AND DISCUSSION distance between the upper and lower arm of the lateral canthus (arrows) have
to be obtained to decompress a retrobulbar hemorrhage.
Apart from airway compromise, RBH is one of the few true
emergencies in head and neck surgery.9
Some pathophysiological mechanisms have been advocated consequently our surgical protocol. This patient, a 14-year-old
for RBH, but none has been demonstrated yet. Still, an increase male presenting rapidly progressing proptosis, pain, and reduction
in intraorbital pressure with a compartment-like syndrome and/or in visual acuity, underwent an immediate LC and IC 45 minutes
ischemia of optical nerve owing to direct pressure by the hematoma after a blunt trauma to the eyeball without fractures. Then the
or stretching of the optical nerve seems to be the most likely definitive exploration of the orbit was carried out under general
mechanism.1,10,11 anesthesia. No source of active bleeding was noted. The patient
Even if the pathophysiology is still unclear, a number of studies recovered completely and showed no reliquates.
confirm that the key concepts for correct resolution of this com- Discussion of traumatic retrobulbar hemorrhage is not within the
plication are a prompt diagnosis and quick surgical management.12 scope of the present paper. However, a 9-patient case series is one of
As demonstrated in an experimental setting by Hayreh and the largest in the literature, despite the majority of them being
Jonas,13 an increase in intraorbital pressure high enough to reduce already published. Therefore, our personal experience, in line with
blood flow in retinal arteries can produce irreversible injuries if the literature, suggests some considerations because the pathophy-
protracted for more than 105 minutes. If the same noxa endures for siology of RBH is shared by iatrogenic and traumatic cases.
more than 240 minutes, then irreversible blindness with optic nerve The diagnosis of iatrogenic RBH would have to be made in
atrophy will result. totally different settings. First, we differentiate between intraopera-
Some clinical studies suggest that there is a window time of tive and postoperative occurrence of RBH.
120 minutes before the onset of permanent injuries to the optic
nerve.14,15
In a previous paper, we have described our experience with 8
Intraoperative Diagnosis of RBH
cases of traumatic and iatrogenic RBH.16 In that series, we were RBH can develop during ESS as well as during periorbital bony
able to surgically decompress the patients within 60-90 minutes in and soft tissue surgery. These 2 conditions are different and have to
all cases but one. All of the patients treated within 60-90 minutes be discussed separately.
had a complete recovery of visual acuity. One patient was treated
with a delay of 12 hours and became blind. RBH Developing During ESS
We have observed and treated 1 additional case of traumatic A retrobulbar hemorrhage can develop during sinus surgery
retrobulbar hemorrhage since then, and we have updated even if it is considered to be an extremely rare event.
The diagnosis of RBH during ESS is essentially surgical. When
the surgeon severs one of the ethmoidal arteries, he or she must pay

FIGURE 8. Inferior transconjunctival incision. A, The lower lid is held with the
FIGURE 6. Inferior cantholysis. The 2 blades of the scissors are placed over the forceps and a subconjunctival tunnel is created with the scissor entering through
inferior arm of the lateral canthus. Its insertion on the periosteum is made clear the canthotomy. B, The conjunctiva is cut 2 mm from the tarsal margin holding
by retracting the lower lid with a forceps. 1 blade of the scissors in the tunnel previously created.

# 2015 Mutaz B. Habal, MD 899


Copyright © 2015 Mutaz B. Habal, MD. Unauthorized reproduction of this article is prohibited.
Colletti et al The Journal of Craniofacial Surgery  Volume 26, Number 3, May 2015

FIGURE 9. The periorbita is incised on the lower rim and the orbital fat herniates
immediately (arrow).

attention to accurately cauterize the orbital edge to avoid retraction FIGURE 11. Often the anterior ethmoidal artery is the source of bleeding. It is
of the bleeding vessel. If the surgeon notes any laceration of an clearly visible through a medial wall access. A, Cadaveric study of the anterior
ethmoidal artery and this latter retracts inside the orbit, then a high ethmoidal artery (arrow). B, Surgical appearance of the anterior (small arrow)
and posterior (big arrow) ethmoidal arteries.
index of alertness for the development of RBH has to be raised. As a
first maneuver, the surgeon can try to follow the route of the artery
inside the orbit by removing part of the lamina papyracea. This the level of the external canthus as our experience with 9 cases
allows to create a drainage route for the blood and one can try to suggests.
coagulate the vessel.
If, in the meantime, RBH is suspected because the eye
becomes proptotic and the pupillary reflex is lost, then an external RBH Occurring During Awakening in the
approach must be switched to immediately. By external approach, Operatory Room After ESS
we mean performing LC and IC and then, as described in the At the time of awakening, a rise in arterial pressure is likely to
technique section, accessing the medial orbital wall through a lower occur. This can reopen an artery inadvertently severed during ESS.
lid transconjunctival access with retrocaruncular extension (see The first thing to do is to remove the nasal packing and to elevate the
Surgical Technique). head of the patient. A free route of drainage for the orbital blood is
In this case, carrying on with the endonasal approach would therefore obtained, even if this may cause massive bleeding from
waste precious time. the nose. Endoscopic reexploration may be time-consuming,
Moreover, removing a major part of the lamina papyracea may in particular if the instruments have been already removed from
cause enophthalmos. The latter develops in untreated medial wall the operatory table. We recommend to immediately perform an
fractures when the bony medial wall is fractured out and the orbital external approach with LC and IC under local anesthesia. In the
periosteum is breached.17 The same mechanism is intentionally meantime, the patient can be narcotized again and the definitive
provoked during endoscopic treatment of Graves-Basedow dis- treatment can be accomplished.
ease–related exophthalmos where, again, the medial orbital bony
wall is removed and the periosteum incised.18 Yet, we have no
direct experience about sequelae of endonasal management as we RBH Developing During or Immediately After
always managed RBH by means of external approach. Periorbital Surgery
On the other hand, an external approach is totally respectful on A retrobulbar hemorrhage can happen intraoperatively as a
orbital walls and therefore we consider it less prone to develop result of orbital surgery (trauma, secondary corrections of enopthal-
enophthalmos. Moreover, an external palpebral approach will leave mos, etc.) or on periorbital tissues (blepharoplasty, etc.).
inconspicuous sequelae, the most remarkable being a small scar at RBH in these cases is likely caused by an arterial bleeding7 and
it will develop rapidly.
If surgery was performed under local anesthesia, then RBH is
suspected on the basis of rapidly developing proptosis and decrease
in visual acuity. Pain could be assent owing to the local anesthetic.
If RBH is suspected, an immediate canthotomy with inferior
cantholysis is accomplished (see Surgical Technique) in all cases
except if RBH develops during inferior subciliar or subtarsal access,
as it can be the case in lower lid blepharoplasty. In these circum-
stances, a lateral canthotomy and inferior cantholysis would pose
the lower lid at high risk of vascular compromise. Thus, in these
cases, the previous access is widened if necessary to gain access to
the orbital septum that is opened along with the orbital periosteum.
The inferior arm of the lateral canthus can be detached with this
access. Opening the septum and the periosteum and releasing the
canthus can significantly reduce the orbital pressure and allow for
FIGURE 10. A, The periosteum of the inferior orbital wall is elevated and the the definitive management of the hemorrhage.
insertion of the inferior oblique muscle (arrow) is cut. B, The dissection proceeds
towards the medial wall and the incision passes lateral to the caruncula lacrimalis
Any hematoma is then removed and the source of bleeding is
(small arrow) while holding the conjunctiva with the forceps (big arrow). C, looked for and stopped. Whether this can be found or not, the wound
Finally, the medial wall is inspected. is left opened and a Penrose drainage is left in place. Forty-eight

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Copyright © 2015 Mutaz B. Habal, MD. Unauthorized reproduction of this article is prohibited.
The Journal of Craniofacial Surgery  Volume 26, Number 3, May 2015 Retrobulbar Hemorrhage

hours after, if no signs of recurrence of the RBH are noted, the CONCLUSIONS
wound can be closed in layers. As with other surgical emergencies, a straightforward decisional
process is of the uttermost importance. No delays in treatment have
to occur and bedside measures as well as definitive treatments have
RBH Occurring in the Monitoring Room After to be performed as soon as possible once the diagnosis is made.
Awakening
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