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Perhitungan Parameter Farmakokinetik
Perhitungan Parameter Farmakokinetik
PRAKTIKUM 3
Kurva Kalibrasi
Parameter Farmakokinetik
Mg
t X FP FK %
Y Terdisolusi % Kadar AUC
(menit) (µg/ml) (µg) (µg) Terdisolusi
(mg)
0 0 0 0 0 0 0 0 0
5 0,0448 -0,02 1.120 0 1,12 0,56% 0,56% 1,4
10 0,5373 0,013 13.432,5 0,0224 13,4325 6,7162% 6,7162 18,1905
15 0,6119 0,018 15.297,5 268,65 15,2975 7,6487% 7,6487% 35,9122
30 0,7910 0,030 19.775 305,95 20,0436 10,0218% 9,8875% 132,5287
45 0,8955 0,037 22.387,5 395,5 22,9621 11,4815% 11,1937% 161,2748
60 0,9701 0,042 24.253,5 447,75 25,2236 12,6118% 12,1267% 180,6698
X
𝑦−𝑎
Y = a+bx / X= 𝑏
𝑦−𝑎 0,02−(−0,023)
Menit ke-5 x= , = 0,0448 µg/ml
𝑏 0,067
𝑦−𝑎 0,013−(−0,023)
Menit ke-10 x= = 0,5373 µg/ml
𝑏 0,067
𝑦−𝑎 0,018−(−0,023)
Menit ke-15 x= = 0,6119 µg/ml
𝑏 0,067
𝑦−𝑎 0,030−(−0,023)
Menit Ke-30 x= = 0,7910 µg/ml
𝑏 0,067
𝑦−𝑎 0,037−(−0,023)
Menit ke-45 x= = 0,8955 µg/ml
𝑏 0,067
𝑦−𝑎 0,042−(−0,023)
Menit ke-60 x= = 0,9701 µg/ml
𝑏 0,067
FP
FK
𝑣𝑜𝑙𝑢𝑚𝑒 𝑐𝑢𝑝𝑙𝑖𝑘𝑎𝑛
Fk= x Fp sebelum
𝑣𝑜𝑙𝑢𝑚𝑒 𝑚𝑒𝑑𝑖𝑢𝑚
5 𝑚𝑙
Menit ke-5= 250 𝑚𝑙 x 0 µg = 0 µg
5 𝑚𝑙
Menit ke-10= 250 𝑚𝑙 x 1.120 µg = 0,0224 µg
5 𝑚𝑙
Menit ke-15= 250 𝑚𝑙 x 13.432,5 µg = 268,65 µg
5 𝑚𝑙
Menit ke-30= 250 𝑚𝑙 x 15.297,5 µg = 305,95 µg
5 𝑚𝑙
Menit ke-45= 250 𝑚𝑙 x 19.775 µg = 395,5 µg
5 𝑚𝑙
Menit ke-60= 250 𝑚𝑙 x 22.387,5 µg = 447,75 µg
MG TERDISOLULUSI
Mg Terdisolusi= Fp + Fk Sebelum
Menit ke-60= 24.253,5 + 395,5+ 305,95 + 268,65 + 0,0224 + 0 = 25.223,6 µg 25,2236 mg
% TERDISOLUSI
𝑚𝑔 𝑡𝑒𝑟𝑑𝑖𝑠𝑜𝑙𝑢𝑠𝑖
1. Menit ke 5 = 𝑏𝑒𝑟𝑎𝑡 𝑧𝑎𝑡 𝑎𝑘𝑡𝑖𝑓 x 100%
1,12 𝑚𝑔
= x 100 % = 0,56 %
200 𝑚𝑔
𝑚𝑔 𝑡𝑒𝑟𝑑𝑖𝑠𝑜𝑙𝑢𝑠𝑖
2. Menit ke 10 = 𝑏𝑒𝑟𝑎𝑡 𝑧𝑎𝑡 𝑎𝑘𝑡𝑖𝑓 x 100%
13,4325 𝑚𝑔
= x 100% = 6,71625%
200 𝑚𝑔
𝑚𝑔 𝑡𝑒𝑟𝑑𝑖𝑠𝑜𝑙𝑢𝑠𝑖
3. Menit ke 15 = 𝑏𝑒𝑟𝑎𝑡 𝑧𝑎𝑡 𝑎𝑘𝑡𝑖𝑓 x 100%
15,2975 𝑚𝑔
= x 100 % = 7,6487 %
200 𝑚𝑔
𝑚𝑔 𝑡𝑒𝑟𝑑𝑖𝑠𝑜𝑙𝑢𝑠𝑖
4. Menit ke 30 = 𝑏𝑒𝑟𝑎𝑡 𝑧𝑎𝑡 𝑎𝑘𝑡𝑖𝑓 x 100%
20,0436 𝑚𝑔
= x 100% = 10,0218%
200 𝑚𝑔
𝑚𝑔 𝑡𝑒𝑟𝑑𝑖𝑠𝑜𝑙𝑢𝑠𝑖
5. Menit ke 45 = 𝑏𝑒𝑟𝑎𝑡 𝑧𝑎𝑡 𝑎𝑘𝑡𝑖𝑓 x 100%
22,9624 𝑚𝑔
= x 100 % = 11,4812%
200 𝑚𝑔
𝑚𝑔 𝑡𝑒𝑟𝑑𝑖𝑠𝑜𝑙𝑢𝑠𝑖
6. Menit ke 60 = 𝑏𝑒𝑟𝑎𝑡 𝑧𝑎𝑡 𝑎𝑘𝑡𝑖𝑓 x 100%
25,2236 𝑚𝑔
= x 100% = 12,6118%
200 𝑚𝑔
% KADAR
𝐹𝑝 (𝑚𝑔)
1. Menit ke 5 = 𝐵𝑒𝑟𝑎𝑡 𝑧𝑎𝑡 𝑎𝑘𝑡𝑖𝑓 x 100%
0,112 𝑚𝑔
= x 100% = 0,056%
200 𝑚𝑔
𝐹𝑝 (𝑚𝑔)
2. Menit ke 10 = 𝐵𝑒𝑟𝑎𝑡 𝑧𝑎𝑡 𝑎𝑘𝑡𝑖𝑓 x 100%
1,34325 𝑚𝑔
= x 100% = 0,6716%
200 𝑚𝑔
𝐹𝑝 (𝑚𝑔)
3. Menit ke 15 = 𝐵𝑒𝑟𝑎𝑡 𝑧𝑎𝑡 𝑎𝑘𝑡𝑖𝑓 x 100%
1,52975 𝑚𝑔
= x 100% = 0,7648%
200 𝑚𝑔
𝐹𝑝 (𝑚𝑔)
4. Menit ke 30 = 𝐵𝑒𝑟𝑎𝑡 𝑧𝑎𝑡 𝑎𝑘𝑡𝑖𝑓 x 100%
1,9775 𝑚𝑔
x 100% = 0,9887%
200 𝑚𝑔
𝐹𝑝 (𝑚𝑔)
5. Menit ke 45 = 𝐵𝑒𝑟𝑎𝑡 𝑧𝑎𝑡 𝑎𝑘𝑡𝑖𝑓 x 100%
2,2387 𝑚𝑔
= x 100% = 1,1194%
200 𝑚𝑔
𝐹𝑝 (𝑚𝑔)
6. Menit ke 60 = 𝐵𝑒𝑟𝑎𝑡 𝑧𝑎𝑡 𝑎𝑘𝑡𝑖𝑓 x 100%
2,4252 𝑚𝑔
= x 100% = 1,2126%
200 𝑚𝑔
AUC
0,56+6,7162 𝑚𝑔.𝑚𝑒𝑛𝑖𝑡
Menit ke-10 = x 5 = 18,1905
2 𝐿
6,7162+7,6487 𝑚𝑔.𝑚𝑒𝑛𝑖𝑡
Meni ke-15 = x 5 = 35,9122
2 𝐿
7,6487+10,0218 𝑚𝑔.𝑚𝑒𝑛𝑖𝑡
Menit ke-30 = x 15 = 132,5287
2 𝐿
10,0218+11,4815 𝑚𝑔.𝑚𝑒𝑛𝑖𝑡
Menit ke-45 = x 15 = 161,2748
2 𝐿
11,4815+12,6118 𝑚𝑔.𝑚𝑒𝑛𝑖𝑡
Menit ke-60 = x 15 = 180,6998
2 𝐿
𝑚𝑔.𝑗𝑎𝑚
No. T Cp (µg/ml) Ln Cp AUC 𝐿
1 5 0,0448 -0,1055 0,112
2 10 0,5373 -0,6212 1,5462
3 15 0,6119 -0,4912 2,964
4 30 0,7910 -0,2345 10,5217
5 45 0,8955 -0,1104 18,5812
6 60 0,9701 -0,0304 20,7082
a = -1,7465
AUC
b = - 0,0357
0+0,0448 𝑚𝑔.𝑚𝑒𝑛𝑖𝑡
Menit ke-5 = x 5 = 0,112
r = - 0,6602 2 𝐿
0,0448+0,5737 𝑚𝑔.𝑚𝑒𝑛𝑖𝑡
K = - 0,0357 menit -1 Menit ke-10 = x 5 = 1,5462
2 𝐿
0,6119+0,7910 𝑚𝑔.𝑚𝑒𝑛𝑖𝑡
Cmax = 0,9701 µg/ml Menit ke-30 = x 15 = 10,5217
2 𝐿
0,955+0,9701 𝑚𝑔.𝑚𝑒𝑛𝑖𝑡
Menit ke-60 = x 15 = 20,7082
2 𝐿
Ln Cp = ln Cp – k.t
Cp0 = ln 0,0053
= -5,2400 µg/ml
𝐷𝑜𝑜𝑠𝑖𝑠 100 𝑚𝑔
Vd = = −5,2400 𝑚𝑔/𝐿 = -19,0840 L
𝐶𝑝
CL = Vd .K
= -0,6813 L/menit
𝐷𝑜𝑠𝑖𝑠 100 𝑚𝑔 𝑚𝑔.𝑚𝑒𝑛𝑖𝑡
AUC = = −0,6813 𝐿/𝑚𝑒𝑛𝑖𝑡 = -146,7782
𝐶𝐿 𝐿
2.4254 %
2.5 2.2388 %
1.9775 %
2
1.5298 %
% Kadar
1.5 1.3433 %
0.5
0.112 %
0
5 10 15 30 45 60
T (Waktu)
0.6119 µg
0.6 0.5373 µg
0.4
0.2
0.0448 µg
0
5 10 15 30 45 60
T (Menit)