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Pall Filter ModulesSolutions
and Capsules
with Seitz® Depth Filter Sheets
Improving choice, flexibility and costs of purification processes
The most efficient and economical way to filter every biopharmaceutical process
Pall Filter Modules and Capsules with Seitz Depth Filter Sheets
The most efficient and economical way to filter every biopharmaceutical process
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Pall Filter Modules and Capsules with Seitz Depth Filter Sheets
The most efficient and economical way to filter every biopharmaceutical process
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Seitz Depth Filter Sheets
Superior retention, consistency, and quality
• Superior manufacturing Pall has many years of experience in every biopharmaceutical application.
process control provides manufacturing filter sheets that meet Pall’s manufacturing capacity can make
consistent performance that the strict requirements of the it possible to deliver an entire year’s
ensures smooth scale-up. biotechnology and pharmaceutical requirements from a single production
industries. Manufacturing is performed run for ultimate process consistency.
• Pall provides unique filter using stringent in-process control
matrices that deliver methods to assure constant filtration P-Series depth filter sheets
finer retention ratings performance and high purity of the The P-Series depth filter sheets are
down to 0.1 µm. filter medium. Pall has developed filter specially designed to meet the strict
matrices specifically for the needs of requirements of the biotechnology and
• Pall provides the industry’s the biopharmaceutical industry that pharmaceutical industries. They cover
widest range of filter sheet assure nominal retention ratings down the full range of needs from bioburden
grades, making it possible to 0.1 µm for optimal filtration of reduction (typical LRV of 9.5 with EKSP
to find the perfect match for biological products and protection of grade using Brevundimonas diminuta),
virtually every application. downstream processing systems. fine filtration, clarifying filtration to coarse
filtration. Strict manufacturing controls
• Pall provides validation
All Seitz filter sheets are produced under ensure high purity of the filter medium
guides for pharmaceutical-
rigorous quality standards at an and constant filtration quality. Pall
grade sheets that reduce
ISO 9001 facility that customers may demonstrates its commitment to the
the time and cost required
inspect and audit. Finer retention ratings biopharmaceutical industry by delivering
for validation.
and consistent performance have strong endotoxin control, low level
propelled Pall into the leadership position Beta Glucan grades, and providing a
SUPRAdisc I module with
AKS grade media
in depth filter sheet media. complete validation guide Pall document
(USTR 2366 and data sheet document
Pall offers tighter grade sheets that USD 2205).
remove smaller particles as
required by the most critical HP-series depth filter sheet
biopharmaceutical processes. The HP-series depth filter sheets are
comprised of two full thickness, graded,
Pall’s superior manufacturing high-efficiency P-Series depth filter
process control ensures sheets in combination. This technology
consistent quality, performance, compresses clarification processing
and scalability of our Seitz depth steps, saving time and resources, and
filter sheets from batch to batch. reducing operation costs. High purity
Pall provides a wide range of pharmaceutical grade depth filter sheets
filter sheet classes and grades are optimized for low endotoxin and low
with different permeabilities as extractable levels and are supported with
well as materials of construction. their own unique validation guide Pall
This makes it possible to provide document (USTR 2404 and data sheet
an optimal sheet for essentially document USD 2335).
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Seitz Depth Filter Sheets
Superior retention, consistency, and quality
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SUPRAdisc Depth Filter Modules
Formatting Seitz sheets in a new design
Depth filter sheets have been The individual filter cells, making up each
• More filter area per module.
successfully used for a vast range of SUPRAdisc module, are constructed by
• Up to 5 m (54 ft ), the
2 2 applications using an array of equipment joining two or more depth filter sheets
industry’s highest level of primarily based on filter presses. separated by a single polypropylene
filter area per industry With their excellent mechanical strength, drainage plate and edge-sealed in an
standard size module. Seitz depth filter sheets can be readily injection molding process. The drainage
incorporated into SUPRAdisc modules plate aids with the flow distribution as
• Enables reduction in capital
and installed into enclosed filter well as provides downstream support
equipment costs by reducing
housings. This arrangement reduces to the filter sheets to guarantee an
number of modules.
cleaning and cleaning validation, excellent flow distribution throughout
• More rigid design allows up simplifies installation, and reduces time the entire module and to increase
to four (4) filters to be between batches. filter cell stability.
stacked vertically for
unparalleled density — SUPRAdisc depth filter modules provide SUPRAdisc depth filter modules
up to 20 m2 (215 ft2) of more filter area than competitors are built around a polypropylene
available surface area. modules within the same industry tubular center core that supports the
standard dimensions. The largest 16 in. individual filter cells and adapters.
• Wide range of module styles
SUPRAdisc modules offer 5 m2 (54 ft2) of
and sizes and filter media
filter area — the highest level of any The rigid center core carries the load
enable SUPRAdisc modules
to be applied to nearly any module in the industry. This may help in when the modules are stacked vertically.
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SUPRAdisc Depth Filter Modules
Formatting Seitz sheets in a new design
Family of SUPRAdisc modules - 12 in. x 16 cell modules with both flat gasket and double O-ring adapters,
12 in. x 5 cell module with double O-ring adapter and 16 in. x 20 cell module with flat gasket adapter
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SUPRAdisc II Depth Filter Modules
An evolutionary change
• Efficient use of available filter SUPRAdisc II design guards against against damage by eliminating direct
surface area. ruptures caused by over-pressurization. operator handling of the discs.
This eliminates a common problem that
• Eliminates need for direct can cause bypass in other module The new depth filter module can be used
operator handling of filter designs. The use of both an inner and with either a double O-ring or flat gasket
cells to prevent damage and outer separator plate enables more filter housing. The ability to fit either type
ensure uniform performance. efficient use of housing makes it possible to use
of the these modules with a wide range of
• The largest 16 in.
size modules available existing equipment. The molded filter
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SUPRAdisc HP Depth Filter Modules
High performance cell clarification depth filter modules
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SUPRAcap 60 Depth Filter Capsules
Helps get new products to market faster and more efficiently
SUPRAcap 100,
in line capsule with depth SUPRAcap 100 depth filters are offered
filter cartridge shown in a flexible format that enables them to
scale to match your requirements at
every stage of your product's lifecycle.
They are available in both in-line and
T-styles, so they fit different footprints
and needs and multiple filters can be
manifolded together to scale up
production volumes and meet specific
application requirements. The T-style is
ideal for constructing disposable
systems of multiple capsules in series
or in parallel configuration.
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SUPRAcap 100 Depth Filter Capsule
Flexible format filters bring the benefits of disposables to a wide application range
Comparison of Scalability
1.80
1.60
1.40
1.20
1.00
∆p [bar]
SD I module
0.60
0.40
0.20
0.00
0 50 100 150 200 250 300 350
Throughput [L/m2]
Example of scalability of the SUPRAcap 100 capsules in comparison to 60 mm flat sheet (generally small scale process
development) and Supradisc I modules (generally large scale clinical of commercial scale manufacturing)
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SUPRAcap 200 Depth Filter Capsules
High area production filters in a disposable format
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TUV rated Pall Advanta for
SUPRAcap housing with the
dome removed and SUPRAcap
capsules exposed.
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New York - USA
+1 516 484 5400 phone Visit us on the web at www.pall.com/biopharmaceutical
+1 516 801 9548 fax
pharmafilter@pall.com e-mail Pall Corporation has offices and plants throughout the world in locations including:
Argentina, Australia, Austria, Belgium, Brazil, Canada, China, France, Germany,
Portsmouth - Europe India, Indonesia, Ireland, Italy, Japan, Korea, Malaysia, Mexico, New Zealand, Norway,
Poland, Puerto Rico, Russia, Singapore, South Africa, Spain, Sweden, Switzerland,
+44 (0)23 9230 3303 phone
Taiwan, Thailand, United Kingdom, the United States and Venezuela.
+44 (0)23 9230 2506 fax Distributors are located in all major industrial areas of the world.
BioPharmUK@europe.pall.com e-mail
, Pall, Kleenpak, Pall Advanta, Seitz, SUPRAcap and SUPRAdisc are trade marks of Pall Corporation.
Filtration. Separation. Solution. and UpScale are service marks of Pall Corporation.
Part Numbers quoted above are protected by the Copyright of Pall Corporation.