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AMA PRA Credit Designation: The American Society for Surgery of the Hand designates Planners
this Journal-Based CME activity for a maximum of 1.00 AMA PRA Category 1 Credits. David T. Netscher, MD, has no relevant conflicts of interest to disclose. The editorial and education
Physicians should claim only the credit commensurate with the extent of their participation staff involved with this journal-based CME activity has no relevant conflicts of interest to disclose.
in the activity.
Learning Objectives
ASSH Disclaimer: The material presented in this CME activity is made available by the Upon completion of this CME activity, the learner should achieve an understanding of:
ASSH for educational purposes only. This material is not intended to represent the only The pattern and sequence of injured structures with increasing damaging energy and
methods or the best procedures appropriate for the medical situation(s) discussed, but stage of the injury
rather it is intended to present an approach, view, statement, or opinion of the authors Clinical assessment
that may be helpful, or of interest, to other practitioners. Examinees agree to participate Initial and subsequent management
in this medical education activity, sponsored by the ASSH, with full knowledge and Acute and long-term effects of hand compartment syndromes
awareness that they waive any claim they may have against the ASSH for reliance on Long-term complications and secondary injuries
any information presented. The approval of the US Food and Drug Administration is
required for procedures and drugs that are considered experimental. Instrumentation Deadline: Each examination purchased in 2017 must be completed by January 31, 2018, to
systems discussed or reviewed during this educational activity may not yet have received be eligible for CME. A certificate will be issued upon completion of the activity. Estimated
FDA approval. time to complete each JHS CME activity is up to one hour.
Provider Information can be found at http://www.assh.org/Pages/ContactUs.aspx. Copyright ª 2017 by the American Society for Surgery of the Hand. All rights reserved.
Crush injuries of the hand are a rare but devastating phenomenon, with historically poor
outcomes. A compressive force, usually caused by a high-energy mechanism such as a motor
vehicle or industrial accident, crushes and transiently increases the pressures within the hand.
This force acts on the incompressible blood in the vasculature and leads to a dramatic rise in
tissue pressures and damage to multiple tissue types, including bones, blood vessels, nerves,
and soft tissues. A wide zone of injury results from a delayed inflammatory reaction involving
the zone bordering the crushed cells, which may initially belie the severity of the injury. As
From the *Department of Orthopaedic Surgery, Warren Alpert Medical School, Brown Corresponding author: Avi D. Goodman, MD, Department of Orthopaedic Surgery, Warren
University, Providence, Rhode Island. Alpert Medical School, Brown University, 593 Eddy St., Providence, RI 02903; e-mail:
avi_goodman@brown.edu.
Received for publication January 7, 2017; accepted in revised form March 22, 2017.
0363-5023/17/4206-0009$36.00/0
No benefits in any form have been received or will be received related directly or indirectly http://dx.doi.org/10.1016/j.jhsa.2017.03.028
to the subject of this article.
C
RUSH INJURIES TO THE HAND ARE a rare but comorbidities helps determine functional needs and
devastating phenomenon, with historically goals. Although several scoring systems attempt to
poor outcomes.1,2 A compressive force, estimate outcomes, these do not accurately predict the
usually caused by a high-energy mechanism such as a need for amputation over salvage in upper extremity
motor vehicle or industrial accident, crushes and crush injuries.4,6
transiently increases the pressures within the hand.
This force acts on the incompressible blood in Clinical examination
the vasculature and leads to a dramatic rise in tissue
The examination begins with an inspection, looking
pressures causing damage to bones, blood vessels,
for wounds that may indicate open fractures, tendon
nerves, and soft tissues.3 A wide zone of injury results
or nerve injuries, or even an “exploded hand” as
from a delayed inflammatory reaction involving the
described by Graham.3 In this constellation, the
bordering zone, which may initially belie the severity
compressive force generates a predictable injury
of the damage. These injuries go on to produce
pattern, beginning with interosseous muscle extrusion
tremendous inflammation and swelling, potentially
through a tension failure of the skin, commonly in
followed by compartment syndrome, vascular damage,
the first web space where the skin is weakest; this
infection, neurological injury, and tissue necrosis.4
portends a grave prognosis.3 Gross swelling and
Crush injuries with minimal skin disruption can be
palmar convexity may be clues to impending
particularly challenging to accurately diagnose and
compartment syndrome or fracture-dislocations.1,3 A
manage. This paper provides a review of the initial
thorough neurological examination should assess the
evaluation of hand crush injuries as well as short- and
new baseline status of each nerve, including signs of
long-term management strategies.
acute carpal tunnel syndrome. In patients unable
to cooperate, look for dry, red skin as a sign of
DIAGNOSIS AND INITIAL MANAGEMENT sympathetic paralysis; if present, this usually
Many such injuries are associated with high-energy indicates more serious nerve damage (as opposed to
trauma, and Advanced Trauma Life Support princi- neurapraxia). Tendon function in all fingers and the
ples must be applied as necessary to preserve life over thumb should be assessed, through both tenodesis
limb. The patient must be evaluated in a systematic and active motion of each joint, if possible. Most
fashion to avoid missed injuries. importantly, assess the hand for perfusion through
pulses, capillary refill (especially dorsal paronychial
History tissue), warmth/color, and Doppler signals because
Once the patient is stable, a pertinent medical history vascular compromise will often determine operative
should be obtained with particular attention to injury urgency. Acute bleeding should be controlled, most
timing and mechanism; the former is crucial in frequently with direct pressure only because clamp-
determining salvage versus amputation because ing can easily injure nearby nerves.
devascularized muscle can only survive 4 to 6 hours Knowledge of injury patterns assists in prompt and
of warm ischemia.5 An understanding of the injury appropriate methodical evaluation. Graham3 pro-
mechanism can help infer energy level of the crush- posed that the “exploded hand” suffers a sequential
ing force and raise suspicion for occult injuries. pattern, beginning with extrusion of the thenar
Learning the patient’s occupation, handedness, and musculature (noted previously) as the thumb becomes
FIGURE 1: A, B A 3-year-old had an automobile wheel roll over his hand. The hand is swollen and the thumb is forced into extension
and abduction through the hydrostatic effects of swelling. CeE Multiple basilar metacarpal fractures seen on radiographs. F First
web space compartment pressure taken in the operating room measures 97 mm Hg. This was treated by compartment releases and
percutaneous K-wire fixations. G Device used to measure compartment pressures (Stryker, Kalamazoo, MI). (AeF Clinical pictures
courtesy of David Netscher, MD.)
coplanar with the hand, in addition to thumb ray deep tissue necrosis occurs.1,7 However, even this
dislocation and/or fracture. As the arches of the conventional wisdom may be unreliable, as a study by
hand flatten, the force proceeds through metacarpal del Piñal et al1 investigating compartment syndrome
headelevel dissociation and carpometacarpal (CMC) in crushed hands showed a significant proportion of
fracture-dislocation of rays II to V. The third stage patients had no pain with passive stretch, perhaps due
involves the pericapitate transmission of forces, to concomitant neurological injury or masked by
manifested by intercarpal ligament disruption. The fractures. A rising analgesia requirement is a useful
fourth stage sees characteristic longitudinal fractures alternative in children and the unconscious. The classic
of the tubular bones. Finally, the fifth stage is neu- intrinsic-minus position of hand compartment syn-
rovascular compromise, resulting in compartment drome is also obscured by the significant swelling
syndrome. associated with crush injuries. In all cases of hand
The surgeon must be vigilant for signs and symp- compartment syndrome following a closed crush
toms of compartment syndrome; with 10 separate injury, del Pinal et al1 found that the thenar and first
muscular compartments, the hand poses a particular web space muscles were involved. In addition,
challenge (Fig. 1). Profuse edema and inflammation Ouellette et al8 showed that 15 of 17 patients (88%)
increase the volume within the fascial compartments, were obtunded at the time of developing compartment
decreasing perfusion to soft tissues and nerves. Of the syndrome. Because of the lack of reliability of clinical
classic “5 Ps” of compartment syndrome (pain, pallor, symptoms and serious implications of a missed diag-
paresthesias, pulselessness, and paralysis), only pain nosis, the surgeon must have a low threshold for
(both out of proportion to clinical examination findings directly measuring compartment pressures.
and with passive stretch) is thought to present early Compartment pressures can be considered either
enough to recognize and treat the pathology before in absolute terms or relative to the diastolic blood
pressure. Whereas the value of absolute intra- crucial to assess and discuss handedness, occupa-
compartmental pressure needed for compartment syn- tional and functional demands, and treatment goals.
drome has been debated (often 30 mm Hg or more) the After appropriate antibiotic administration, anes-
relative pressure difference (DP) is accepted as more thesia, and tourniquet inflation, proximal vascular
accurate. A study did not find any evidence delineating a injuries should be addressed with a bypass, graft,
particular DP causing reduced circulation in the upper or shunt. A careful evaluation is followed by
extremities, but using lower extremity data, it is an aggressive debridement of all suspect tissue.
accepted that a DP less than 30 mm Hg for longer than Bernstein et al5 state that the goal of initial debride-
2 hours compromises perfusion and is more sensitive ment is to achieve a clean wound that looks surgically
and specific than clinical signs.9 The complication rates created and ready for reconstruction. Pressure moni-
with delayed diagnosis are high and include long-term toring and compartment releases are performed when
pain, dysfunction, and intrinsic contractures of necessary, as is provisional coverage over tendons
the hand; thumb contractures are especially poorly and neurovascular structures.a,b Conflicting data exist
tolerated.2,10 Edema and bleeding can evolve over time, regarding the precise timing of coverage, but trends
and as such, it is important to perform serial examina- suggest that the most important factor in preventing
tions. To minimize ischemia, early recognition and complications is the thoroughness of debridement.
judicious action to relieve the elevated pressures are Skeletal management begins with debridement
critical, including removing extrinsic compression, of devitalized bones, followed by stabilization of frac-
elevating the extremity, and ultimately fasciotomizing tures or dislocations (using K-wires, plates, or external
all involved compartments.7,8,11 fixation), with the goal of early motion and stiffness
prevention. Extensive dissection associated with plate
Imaging and laboratory tests fixation should be avoided to preserve any bone-healing
Radiographs of the hand, wrist, and forearm can biology, especially in the acute phase. In addition to
identify for fractures, dislocations, and preexisting restoring blood flow, venous drainage should be rees-
bony conditions. If the clinical examination is fairly tablished, with the selective addition of heparin-soaked
benign and the mechanism is unknown, abnormal pledgets, nail plate removal, and leeches. Nerve man-
fracture patterns can indicate a crush mechanism, agement is guided by the examination, with exploration
especially longitudinal tubular bone fractures.3 A warranted if an injury is suspected. If found in conti-
computed tomography scan can also be obtained for nuity, it should be gently cleaned, and if transected,
better characterization of intra- or periarticular frac- should be either cut to the level of healthy tissue and
tures and dislocations, although this should not delay repaired or tagged for later repair.5 The surgeon
operative intervention. Basic laboratory tests as well should have a low threshold for decompression at
as whole blood lactate, creatine kinase, and urinary Guyon canal and the carpal tunnel; the latter should
myoglobin can assess for blood loss anemia, meta- always accompany compartment releases.
bolic derangements, hypoperfusion, and muscle Once the initial debridement and repair is
damage. Fluid resuscitation is often needed to completed, the tourniquet should be released to further
improve end-organ perfusion. Once the initial work- address perfusion. Wound dressings are dictated by the
up is complete, the decision must be made to take extent, quality, and cleanliness of the wound bed.
the patient to the operating room, and how quickly. Antibiotic beads may be considered in particularly
contaminated wounds. Negative pressure wound
therapy can be a useful adjunct in temporary coverage,
MANAGEMENT OF CRUSH INJURIES minimizing swelling and the number of dressing
Initial operative management changes, although the effect on bacterial load, infec-
Given the complexities of such crush injuries, it is tion, and time to closure is debated.12,c Alternatively,
important to consider both short-term tactics and damp-to-dry dressings remain the mainstay of treat-
long-term strategies for management of each ment. The hand should be treated with orthosis fabri-
component: soft tissues, fractures, and neurovascular cation, often in the intrinsic-plus position, and elevated
injuries. First, salvage versus amputation must be to the level of the heart. Depending on coverage and
addressed, but given that no criteria exist for reliably vascular repairs, micro-precautions—with a goal of
and accurately predicting the salvageability of the minimizing peripheral vascular constriction—may be
upper extremity, most surgeons lean heavily toward advisable, including increased room temperature
initial salvage, while maintaining late amputation as and/or heating blanket, anticoagulants (including
an option. If the patient is able to communicate, it is heparin and variants, aspirin, dextran, and others), and
FIGURE 2: A Preoperative clinical picture and B, C radiographs of the reported crushed hand.
those strictly required because excessive collateral Thumb adduction contractures should initially be
ligament disruption may cause joint instability, managed with dynamic orthosis treatment, with
thereby defeating the purpose of the surgery. After an abduction force to the thumb CMC joint.16 If con-
this short immobilization, the patient must begin servative interventions are unsuccessful, the deep fascia
working to maintain these range of motion gains. is split longitudinally and the insertion of the adductor
Proximal interphalangeal joint flexion contractures pollicis muscle is transected. If adduction contracture
should initially be managed with dynamic orthosis persists, a thumb CMC capsulotomy allows release of
treatment or serial casting for several months.16 A the volar intermetacarpal and oblique CMC joint liga-
review of over 400 PIP joint flexion contractures ments, while preserving the radial CMC joint ligament to
initially treated conservatively demonstrated that 87% prevent instability. Correction of the adduction contrac-
of these contractures were managed effectively non- ture results in a skin deficit that often requires coverage.
surgically.19 If these fail, the checkrein ligaments are Ischemic hand contractures often result from
carefully transected via a volar approach to the PIP missed compartment syndrome and present with MCP
joint. If the contracture persists, a volar capsulotomy flexion, PIP and DIP joint extension, and thumb
is performed to allow for a volar plate and accessory adduction—opposite to the contractures seen with an
collateral ligament release. intrinsic-minus hand.16 Delayed hand compartment
syndrome can be detected while the hand is positioned room for an attempt at salvage, although the possibility
in the intrinsic-plus position by passively extending of amputation was discussed.
the MCP joint daily. If this is painful, fasciotomies In the operating room, an irrigation and debride-
should be performed early. Immediately after surgery, ment cleaned the wounds of nonviable tissue. An
the hand should not be positioned in the intrinsic-plus autologous vein graft (taken from the forearm) was
position in order to minimize additional ischemia. needed to restore blood flow from the superficial arch
If ischemic contractures develop, the goals of treat- to the common digital artery to the middle and ring
ment are to prevent stiffness and deformity and to restore fingers. Nerves to the thumb, middle, ring, and little
motion.11 Supervised stretching, mobilization exer- fingers were noted to have segmental injuries. Each
cises, and orthosis treatment with a hand therapist are metacarpal was reduced and pinned with K-wires
the first line of treatment. Littler’s technique involved (Fig. 3), and the carpal tunnel was released; no further
releasing the extensor component of the intrinsic compartment releases were needed given the extent
muscles from the PIP joints and active splinting. of the injury. After the wound was loosely approxi-
mated and dressed, the arm was treated with an
Clinical adjuncts to surgery orthosis and the patient maintained on microsurgery
The hands allow us to perform functions that define us precautions. Four days later, the patient returned to
as humans, including social interaction, self-care, the operating for a repeat irrigation and debridement,
communication, and expression. Given the high de- as well as tagging of the extensor tendons (done
gree to which we rely on our hands in everyday life, without tourniquet to prevent injury to the micro-
hand injuries can have a significant psychological vascular repair). After an uneventful hospital course,
impact on ability to make adjustments and recover he was discharged home 10 days after injury.
from injury.20 Although hand surgeons must under- After surgery, he was seen weekly for 2 weeks (with
stand and recognize the psychological consequences of therapy initiated at 1 week), then every other week for 8
hand injury (such as posttraumatic stress disorder), weeks, mostly complaining of stiffness and neuro-
hand therapists are in a unique position to screen and pathic pain. Despite no longer smoking, his healing
monitor these consequences. Psychological distress was slower than expected. His examination stabilized
can interfere with recovery if not appropriately with healed wounds, diminished but intact sensation in
recognized and addressed. Therefore, patients should all fingers (with variable hypersensitivity), limited
be screened by incorporating questions about changes motion of all fingers, and well-perfused digits.
in sleep patterns, mood, and behavior and, if positive,
referred for additional psychological support within
3 months after the initial injury. ACKNOWLEDGMENTS
The authors thank Jeremy Raducha, MD, and Joseph
CASE PRESENTATION A. Gil, MD, for their clinical care and preparation of
A 66-year-old right-handed gentleman sustained an the manuscript.
isolated injury to his right hand, which was crushed by
a 250-ton press for approximately 10 seconds. In REFERENCES
addition to a degloving injury about his carpus and 1. Del Piñal F, Herrero F, Jado E, García-Bernal FJ, Cerezal L. Acute
metacarpals, he had exposed metacarpal fractures and hand compartment syndromes after closed crush: a reappraisal. Plast
lacerated extensor tendons (Fig. 2A). His sensory ex- Reconstr Surg. 2002;110(5):1232e1239.
amination was variable, and his motor examination 2. Choueka J, Scott SC. Intrinsic contractures of the thumb. Hand Clin.
2012;28(1):67e80.
was notable for an inability to fire most flexors 3. Graham TJ. The exploded hand syndrome: logical evaluation and
(although flexor pollicis longus function was main- comprehensive treatment of the severely crushed hand. J Hand Surg
tained). Despite a Doppler signal present at his palmar Am. 2006;31(6):1012e1023.
4. Friedrich JB, Vedder NB. Mangled upper extremity. In: Wolfe S,
arch, no signals were found in the digits, and his digits Pederson W, Hotchkiss R, Kozin S, Cohen M, eds. Green’s
were cool. Radiographs revealed fractures of meta- Operative Hand Surgery. 7th ed. Philadelphia, PA: Elsevier Health
carpals I to V, including dislocations at the base of the Sciences; 2017:1486e1527.
first and neck of the second (Fig. 2B, C). His medical 5. Bernstein ML, Chung KC. Early management of the mangled upper
extremity. Injury. 2007;38(Suppl 5):S3eS7.
history was significant only for hyperlipidemia and a 6. Togawa S, Yamami N, Nakayama H, Mano Y, Ikegami K, Ozeki S.
25-pack-year smoking history. In the emergency The validity of the mangled extremity severity score in the assess-
department, the patient was provisionally irrigated, ment of upper limb injuries. J Bone Joint Surg Br. 2005;87(11):
1516e1519.
supplied with an orthosis, and given appropriate anti- 7. Codding JL, Vosbikian MM, Ilyas AM. Acute compartment syn-
biotics. He was then taken emergently to the operating drome of the hand. J Hand Surg Am. 2015;40(6):1213e1216.
8. Ouellette EA, Kelly R. Compartment syndromes of the hand. J Bone diagnosis, management, and outcomes. J Child Orthop.
Joint Surg Am. 1996;78(10):1515e1522. 2013;7(3):225e233.
9. Ulmer T. The clinical diagnosis of compartment syndrome of the 18. Dorf E, Blue C, Smith BP, Koman LA. Therapy after injury to the
lower leg: are clinical findings predictive of the disorder? J Orthop hand. J Am Acad Orthop Surg. 2010;18(8):464e473.
Trauma. 2002;16(8):572e577. 19. Weeks PM, Wray RC, Kuxhaus M. The results of non-operative
10. Duckworth AD, Mitchell SE, Molyneux SG, White TO, Court- management of stiff joints in the hand. Plast Reconstr Surg.
Brown CM, McQueen MM. Acute compartment syndrome of the 1978;61(1):58e63.
forearm. J Bone Joint Surg Am. 2012;94(10):e63. 20. Hannah SD. Psychosocial issues after a traumatic hand injury:
11. Leversedge FJ, Moore TJ, Peterson BC, Seiler JG. Compartment facilitating adjustment. J Hand Ther. 2011;24(2):95e103.
syndrome of the upper extremity. J Hand Surg Am. 2011;36(3):
544e559; quiz 560.
12. Krug E, Berg L, Lee C, et al. Evidence-based recommendations for EDITOR’S SUGGESTIONS FOR MORE
the use of Negative Pressure Wound Therapy in traumatic wounds INFORMATION
and reconstructive surgery: steps towards an international consensus.
Injury. 2011;42(Suppl 1):S1eS12. The Editor chose to include these references and video to provide readers
13. Friedrich JB, Katolik LI, Vedder NB. Soft tissue reconstruction of the with additional information.
hand. J Hand Surg Am. 2009;34(6):1148e1155. a. Leversedge FJ, Moore TJ, Peterson BC, Seiler JG. Compartment syn-
14. Oak NR, Abrams RA. Compartment syndrome of the hand. Orthop drome of the upper extremity. J Hand Surg Am. 2011;36(3):544e559.
Clin North Am. 2016;47(3):609e616. b. Stevanovic M. Fasciotomy for Compartment Syndrome [see Video;
15. Kalyani BS, Fisher BE, Roberts CS, Giannoudis PV. Compartment available on the Journal’s Web site at www.jhandsurg.org)]. Presented
syndrome of the forearm: a systematic review. J Hand Surg Am. at: American Society for Surgery of the Hand and American Associ-
2011;36(3):535e543. ation for Hand Surgery Specialty Day: March 23, 2013; Chicago, IL.
16. Tajima T. Treatment of post-traumatic contracture of the hand. Also available at: Hand-e: http://www.assh.org/Hand-e.
J Hand Surg Br. 1988;13(2):118e129. c. Taylor CJ, Chester DL, Jeffery SL. Functional splinting of upper limb
17. Kanj WW, Gunderson MA, Carrigan RB, Sankar WN. injuries with gauze-based topical negative pressure wound therapy.
Acute compartment syndrome of the upper extremity in children: J Hand Surg Am. 2011;36(11):1848e1851.
Crush Injuries of the Hand 3. What is the most accurate scoring system for
crushing hand injuries to assess the need for
1. Which of the following is most frequently amputation?
associated with crush injuries of the hand? a. No scoring system has proven sufficiently
a. Compartment syndrome involving thenar and predictive
first webspace
b. Mangled Extremity Severity Score (MESS)
b. Compartment syndrome involving hypothenar
c. Injury Severity Score (ISS)
space
d. Disability of Arm, Hand and Shoulder (DASH)
c. Perilunate dislocation
score
d. Fingertip amputations
e. Glasgow coma score
e. Vascular compromise
4. Which of the following is inessential at the initial
2. What is the typical radiographic finding with surgery following a crush injury?
crush injuries of the hand?
a. Thorough debridement to bleeding tissue
a. Hamate fracture b. Reestablish vascular flow
b. Longitudinal fractures of tubular bones c. Skeletal stabilization
c. Metacarpophalangeal joint dislocation of ulnar
d. Definitive soft tissue coverage
fingers
e. Release necessary compartments
d. Radial styloid fracture
e. Scapholunate disassociation